Low-dose craniospinal irradiation as a definitive treatment for intracranial germinoma

Jaeho Cho, Joong Uhn Choi, Dong Seok Kim, Chang Ok Suh

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Purpose: To determine the optimal radiotherapy (RT) dose and volume for treatment of intracranial germinoma. Materials and methods: Eighty-one intracranial germinoma patients (33 pathologically-verified; 48 presumed by radiosensitivity testing) treated with RT alone between 1971 and 2002 were analyzed. The RT volume varied from focal (13) to whole brain (8), or to the entire neuraxis (60). All the cases after 1982 received craniospinal irradiation (CSI). Radiation dose was reduced gradually during the study period from 59 to 39.3 Gy for primary tumors, and from 34.2 to 19.5 Gy for the neuraxis. The median follow-up time was 120 months (48-260 months). Results: Five- and ten-year relapse-free survival rates were 98.8% and 94.1%, respectively. All the recurrences occurred in the patients who received local (4/13) or whole brain RT (1/8). None of the patients who received CSI suffered from a recurrence. Forty-six patients received 45 Gy or less to the primary site and 22 patients received less than 20 Gy to the spinal axis. Conclusion: Low-dose CSI-based RT should remain the standard treatment for intracranial germinoma. The RT dose can be reduced to 39.3 Gy for primary tumor sites and to 19.5 Gy for the spinal axis.

Original languageEnglish
Pages (from-to)75-79
Number of pages5
JournalRadiotherapy and Oncology
Volume91
Issue number1
DOIs
Publication statusPublished - 2009 Apr 1

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Craniospinal Irradiation
Germinoma
Radiotherapy
Recurrence
Therapeutics
Radiation Tolerance
Brain
Neoplasms
Survival Rate
Radiation

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

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abstract = "Purpose: To determine the optimal radiotherapy (RT) dose and volume for treatment of intracranial germinoma. Materials and methods: Eighty-one intracranial germinoma patients (33 pathologically-verified; 48 presumed by radiosensitivity testing) treated with RT alone between 1971 and 2002 were analyzed. The RT volume varied from focal (13) to whole brain (8), or to the entire neuraxis (60). All the cases after 1982 received craniospinal irradiation (CSI). Radiation dose was reduced gradually during the study period from 59 to 39.3 Gy for primary tumors, and from 34.2 to 19.5 Gy for the neuraxis. The median follow-up time was 120 months (48-260 months). Results: Five- and ten-year relapse-free survival rates were 98.8{\%} and 94.1{\%}, respectively. All the recurrences occurred in the patients who received local (4/13) or whole brain RT (1/8). None of the patients who received CSI suffered from a recurrence. Forty-six patients received 45 Gy or less to the primary site and 22 patients received less than 20 Gy to the spinal axis. Conclusion: Low-dose CSI-based RT should remain the standard treatment for intracranial germinoma. The RT dose can be reduced to 39.3 Gy for primary tumor sites and to 19.5 Gy for the spinal axis.",
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Low-dose craniospinal irradiation as a definitive treatment for intracranial germinoma. / Cho, Jaeho; Choi, Joong Uhn; Kim, Dong Seok; Suh, Chang Ok.

In: Radiotherapy and Oncology, Vol. 91, No. 1, 01.04.2009, p. 75-79.

Research output: Contribution to journalArticle

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