Convolutional neural network (CNN) based low-dose CT denoising is effective to deal with complex CT noise. However, CNN denoiser with pixel-level loss functions (e.g., mean-squared-error (MSE) and mean-absolute- error (MAE)) often produces image blur. To overcome this limitation, perceptual loss function (e.g., VGG loss) is adapted to train CNN denoiser. CNN denoiser with VGG loss preserves structural details in denoised images better. However, because VGG network is trained with natural RGB images, which have different image properties from CT images, extracted features would not be related to diagnosis. Also, CNN denoiser with VGG loss introduces a bias of CT number in denoised images. In this work, we propose observer loss to train CNN denoiser. Observer network (i.e., feature extractor in observer loss) is trained with CT images to classify lesion-present and lesion-absent cases. We conduct two binary classification tasks, signal-known-exactly (SKE) and signal-known-statistically (SKS) tasks. Because it is hard to obtain labeled CT images, we insert simulated lesions. CNN denoiser with observer loss preserves small structures and edges in denoised images without introducing bias in CT number.
|Title of host publication||Medical Imaging 2021|
|Subtitle of host publication||Physics of Medical Imaging|
|Editors||Hilde Bosmans, Wei Zhao, Lifeng Yu|
|Publication status||Published - 2021|
|Event||Medical Imaging 2021: Physics of Medical Imaging - Virtual, Online, United States|
Duration: 2021 Feb 15 → 2021 Feb 19
|Name||Progress in Biomedical Optics and Imaging - Proceedings of SPIE|
|Conference||Medical Imaging 2021: Physics of Medical Imaging|
|Period||21/2/15 → 21/2/19|
Bibliographical noteFunding Information:
This work was supported by National Research Foundation of Korea (2019R1A6A3A01092732, 2019R1A2C2084936, 2020R1A4A1016619).
© COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.
All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
- Radiology Nuclear Medicine and imaging