Low-dose thiazide diuretics in children with idiopathic renal hypercalciuria

Ji Na Choi, Jae Seung Lee, Jaeil Shin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Abtract Aim: To evaluate the therapeutic effect of hydrochlorothiazide in idiopathic renal hypercalciuria. Methods: We retrospectively analysed the data of 28 children (6.0 ± 4.1 years, M:F = 19:9) diagnosed as having idiopathic renal hypercalciuria from the years 1991 to 2008. The dose of hydrochlorothiazide was initially 0.5 mg/kg/day and gradually increased to achieve the appropriate hypocalciuric effect (urinary calcium/creatinine <0.2 mg/mg) in some unresponsive patients. Results: Twenty-two patients (79%) had gross haematuria, 6 (21%) microscopic haematuria, 2 left flank pain, 6 (21%) urolithiasis and 9 (32%) urinary tract infection at the diagnosis of hypercalciuria. The low doses (0.5 mg/kg/day) of hydrochlorothiazide reduced urinary calcium excretion in 25 patients (89%) and 3 (11%) required the increased doses (1-2 mg/kg/day). Haematuria and urolithiasis gradually resolved in accordance with the improvement of hypercalciuria. Nineteen patients (68%) maintaining hypocalciuria during hydrochlorothiazide therapy were discontinued after 12.5 ± 5.3 months of treatment. Eleven of the 19 patients maintained normocalciuria, while 8 showed increased urinary calcium excretion at 2.9 ± 2.3 months after treatment was stopped, requiring thiazide retreatment. Conclusion: Our results suggest that low dose (0.5 mg/kg/day) of hydrochlorothiazide may be safe and effective in controlling renal hypercalciuria in children.

Original languageEnglish
JournalActa Paediatrica, International Journal of Paediatrics
Volume100
Issue number8
DOIs
Publication statusPublished - 2011 Aug 1

Fingerprint

Sodium Chloride Symporter Inhibitors
Hypercalciuria
Hydrochlorothiazide
Kidney
Hematuria
Urolithiasis
Calcium
Thiazides
Flank Pain
Retreatment
Therapeutic Uses
Urinary Tract Infections
Creatinine
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

@article{f6eb8df08daa4ac3adf0172579b7e9b9,
title = "Low-dose thiazide diuretics in children with idiopathic renal hypercalciuria",
abstract = "Abtract Aim: To evaluate the therapeutic effect of hydrochlorothiazide in idiopathic renal hypercalciuria. Methods: We retrospectively analysed the data of 28 children (6.0 ± 4.1 years, M:F = 19:9) diagnosed as having idiopathic renal hypercalciuria from the years 1991 to 2008. The dose of hydrochlorothiazide was initially 0.5 mg/kg/day and gradually increased to achieve the appropriate hypocalciuric effect (urinary calcium/creatinine <0.2 mg/mg) in some unresponsive patients. Results: Twenty-two patients (79{\%}) had gross haematuria, 6 (21{\%}) microscopic haematuria, 2 left flank pain, 6 (21{\%}) urolithiasis and 9 (32{\%}) urinary tract infection at the diagnosis of hypercalciuria. The low doses (0.5 mg/kg/day) of hydrochlorothiazide reduced urinary calcium excretion in 25 patients (89{\%}) and 3 (11{\%}) required the increased doses (1-2 mg/kg/day). Haematuria and urolithiasis gradually resolved in accordance with the improvement of hypercalciuria. Nineteen patients (68{\%}) maintaining hypocalciuria during hydrochlorothiazide therapy were discontinued after 12.5 ± 5.3 months of treatment. Eleven of the 19 patients maintained normocalciuria, while 8 showed increased urinary calcium excretion at 2.9 ± 2.3 months after treatment was stopped, requiring thiazide retreatment. Conclusion: Our results suggest that low dose (0.5 mg/kg/day) of hydrochlorothiazide may be safe and effective in controlling renal hypercalciuria in children.",
author = "Choi, {Ji Na} and Lee, {Jae Seung} and Jaeil Shin",
year = "2011",
month = "8",
day = "1",
doi = "10.1111/j.1651-2227.2011.02191.x",
language = "English",
volume = "100",
journal = "Acta Paediatrica, International Journal of Paediatrics",
issn = "0803-5253",
publisher = "Wiley-Blackwell",
number = "8",

}

Low-dose thiazide diuretics in children with idiopathic renal hypercalciuria. / Choi, Ji Na; Lee, Jae Seung; Shin, Jaeil.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 100, No. 8, 01.08.2011.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Low-dose thiazide diuretics in children with idiopathic renal hypercalciuria

AU - Choi, Ji Na

AU - Lee, Jae Seung

AU - Shin, Jaeil

PY - 2011/8/1

Y1 - 2011/8/1

N2 - Abtract Aim: To evaluate the therapeutic effect of hydrochlorothiazide in idiopathic renal hypercalciuria. Methods: We retrospectively analysed the data of 28 children (6.0 ± 4.1 years, M:F = 19:9) diagnosed as having idiopathic renal hypercalciuria from the years 1991 to 2008. The dose of hydrochlorothiazide was initially 0.5 mg/kg/day and gradually increased to achieve the appropriate hypocalciuric effect (urinary calcium/creatinine <0.2 mg/mg) in some unresponsive patients. Results: Twenty-two patients (79%) had gross haematuria, 6 (21%) microscopic haematuria, 2 left flank pain, 6 (21%) urolithiasis and 9 (32%) urinary tract infection at the diagnosis of hypercalciuria. The low doses (0.5 mg/kg/day) of hydrochlorothiazide reduced urinary calcium excretion in 25 patients (89%) and 3 (11%) required the increased doses (1-2 mg/kg/day). Haematuria and urolithiasis gradually resolved in accordance with the improvement of hypercalciuria. Nineteen patients (68%) maintaining hypocalciuria during hydrochlorothiazide therapy were discontinued after 12.5 ± 5.3 months of treatment. Eleven of the 19 patients maintained normocalciuria, while 8 showed increased urinary calcium excretion at 2.9 ± 2.3 months after treatment was stopped, requiring thiazide retreatment. Conclusion: Our results suggest that low dose (0.5 mg/kg/day) of hydrochlorothiazide may be safe and effective in controlling renal hypercalciuria in children.

AB - Abtract Aim: To evaluate the therapeutic effect of hydrochlorothiazide in idiopathic renal hypercalciuria. Methods: We retrospectively analysed the data of 28 children (6.0 ± 4.1 years, M:F = 19:9) diagnosed as having idiopathic renal hypercalciuria from the years 1991 to 2008. The dose of hydrochlorothiazide was initially 0.5 mg/kg/day and gradually increased to achieve the appropriate hypocalciuric effect (urinary calcium/creatinine <0.2 mg/mg) in some unresponsive patients. Results: Twenty-two patients (79%) had gross haematuria, 6 (21%) microscopic haematuria, 2 left flank pain, 6 (21%) urolithiasis and 9 (32%) urinary tract infection at the diagnosis of hypercalciuria. The low doses (0.5 mg/kg/day) of hydrochlorothiazide reduced urinary calcium excretion in 25 patients (89%) and 3 (11%) required the increased doses (1-2 mg/kg/day). Haematuria and urolithiasis gradually resolved in accordance with the improvement of hypercalciuria. Nineteen patients (68%) maintaining hypocalciuria during hydrochlorothiazide therapy were discontinued after 12.5 ± 5.3 months of treatment. Eleven of the 19 patients maintained normocalciuria, while 8 showed increased urinary calcium excretion at 2.9 ± 2.3 months after treatment was stopped, requiring thiazide retreatment. Conclusion: Our results suggest that low dose (0.5 mg/kg/day) of hydrochlorothiazide may be safe and effective in controlling renal hypercalciuria in children.

UR - http://www.scopus.com/inward/record.url?scp=79960077137&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960077137&partnerID=8YFLogxK

U2 - 10.1111/j.1651-2227.2011.02191.x

DO - 10.1111/j.1651-2227.2011.02191.x

M3 - Article

C2 - 21284722

AN - SCOPUS:79960077137

VL - 100

JO - Acta Paediatrica, International Journal of Paediatrics

JF - Acta Paediatrica, International Journal of Paediatrics

SN - 0803-5253

IS - 8

ER -