Repetitive magnetic stimulation (rMS) has been suggested as a non-invasive treatment for various neurological or psychiatric diseases. Contrary to the application previously used, the purpose of the present study was to elucidate whether low-frequency rMS could suppress tumor progression in in vitro and in vivo neuroblastoma models, and to explore the underlying mechanisms. The results demonstrated that low-frequency rMS treatment significantly suppressed cell proliferation and tumor progression in the models. Moreover, low-frequency rMS treatment downregulated the Wnt/β-catenin signaling pathway and induced apoptosis. The Wnt/β-catenin signaling pathway activator, Wnt agonist, was found to counteract the effect of low-frequency rMS treatment, while the Wnt/β-catenin signaling pathway inhibitor, Wnt antagonist, exhibited a tumor suppression effect, similar to the effect of low-frequency rMS treatment. Taken together, our data demonstrated that low-frequency rMS treatment suppressed neuroblastoma progression by downregulating the Wnt/β-catenin signaling pathway, suggesting that low-frequency rMS treatment may be a potential therapeutic strategy for the tumor suppression.
|Publication status||Published - 2022 Oct|
Bibliographical noteFunding Information:
This study was supported by the National Research Foundation ( NRF-2020R1A2C1012019 , 2022R1A2C1006660 , and 2022R1A2C1006374 ), the faculty research grant of Yonsei University College of Medicine ( 6-2021-0095 ), the Korean Fund for Regenerative Medicine (KFRM) grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Health & Welfare) (21A0202L1), and the grant from Hyundai Motor Chung Mong-Koo Foundation.
© 2022 The Authors
All Science Journal Classification (ASJC) codes
- Physical and Theoretical Chemistry