Low Intraoperative Cerebral Oxygen Saturation Is Associated with Acute Kidney Injury after Off-Pump Coronary Artery Bypass

By monitoring the brain as the index organ of global oxygen supply–demand balance including major organs, regional cerebral oxygen saturation (rScO₂) may indicate adequacy of renal perfusion. The aim of this study was to investigate the relationship between perioperative rScO₂ and acute kidney injury (AKI) after off-pump coronary artery bypass (OPCAB). AKI was diagnosed according to the Kidney Disease: Improving Global Outcomes criteria. Collected rScO₂ variables were baseline, mean, and lowest value during surgery, maximal percentage decrease from baseline, and areas under the threshold below an absolute value of 50% (AUT₅₀) and of 80% of baseline (AUT_80%base). Among 580 patients, AKI developed in 143 (24.7%) patients. Patients with AKI had lower baseline, mean, and lowest rScO₂ and higher AUT₅₀ and AUT_80%base than those without AKI despite routine efforts to restore the rScO₂ values within 20% of the baseline. Among the rScO₂ variables, the area under the receiver operating characteristic curve of mean rScO₂ was the highest (0.636), which was used for the multivariable logistic regression. Multivariable logistic regression revealed mean rScO₂ as an independent predictor of AKI (odds ratio, 0.964; 95% confidence interval, 0.937–0.990; p = 0.008), along with chronic kidney disease and emergency surgery. Low intraoperative mean rScO₂ was independently associated with AKI after OPCAB, which may serve as an early marker of renal injury.