Low mitochondrial DNA copy number is associated with adverse clinical outcomes in peritoneal dialysis patients

Chang Yun Yoon, Jung Tak Park, Youn Kyung Kee, Seung Gyu Han, In Mee Han, Young Eun Kwon, Kyoung Sook Park, Mi Jung Lee, SeungHyeok Han, Shin-Wook Kang, TaeHyun Yoo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Mitochondrial dysfunction may play an important role in abnormal glucose metabolism and systemic inflammation. We aimed to investigate the relationship between mitochondrial DNA (mtDNA) copy number and clinical outcomes in peritoneal dialysis (PD) patients. We recruited 120 prevalent PD patients and determined mtDNA copy number by PCR. Primary outcome was all-cause mortality, whereas secondary outcomes included cardiovascular events, technical PD failure, and incident malignancy. Cox proportional hazards analysis determined the independent association of mtDNA copy number with outcomes. The mean patient age was 52.3 years; 42.5% were men. The mean log mtDNA copy number was 3.30±0.50. During a follow-up period of 35.4±19.3 months, all-cause mortality and secondary outcomes were observed in 20.0% and 59.2% of patients, respectively. Secondary outcomes were significantly lower in the highest mtDNA copy number group than in the lower groups. In multiple Cox analysis, the mtDNA copy number was not associated with allcause mortality (lower two vs highest tertile: hazard ratio [HR]=1.208, 95% confidence interval [CI]=0.477-3.061). However, the highest tertile group was significantly associated with lower incidences of secondary outcomes (lower two vs highest tertile: HR [95% CI]=0.494 [0.277-0.882]) after adjusting for confounding factors. The decreased mtDNA copy number was significantly associated with adverse clinical outcomes in PD patients.

Original languageEnglish
Pages (from-to)e2717
JournalMedicine (United States)
Volume95
Issue number7
DOIs
Publication statusPublished - 2016 Jan 1

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Peritoneal Dialysis
Mitochondrial DNA
Mortality
Confidence Intervals
Inflammation
Glucose
Polymerase Chain Reaction
Incidence
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Yoon, Chang Yun ; Park, Jung Tak ; Kee, Youn Kyung ; Han, Seung Gyu ; Han, In Mee ; Kwon, Young Eun ; Park, Kyoung Sook ; Lee, Mi Jung ; Han, SeungHyeok ; Kang, Shin-Wook ; Yoo, TaeHyun. / Low mitochondrial DNA copy number is associated with adverse clinical outcomes in peritoneal dialysis patients. In: Medicine (United States). 2016 ; Vol. 95, No. 7. pp. e2717.
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Low mitochondrial DNA copy number is associated with adverse clinical outcomes in peritoneal dialysis patients. / Yoon, Chang Yun; Park, Jung Tak; Kee, Youn Kyung; Han, Seung Gyu; Han, In Mee; Kwon, Young Eun; Park, Kyoung Sook; Lee, Mi Jung; Han, SeungHyeok; Kang, Shin-Wook; Yoo, TaeHyun.

In: Medicine (United States), Vol. 95, No. 7, 01.01.2016, p. e2717.

Research output: Contribution to journalArticle

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AU - Yoon, Chang Yun

AU - Park, Jung Tak

AU - Kee, Youn Kyung

AU - Han, Seung Gyu

AU - Han, In Mee

AU - Kwon, Young Eun

AU - Park, Kyoung Sook

AU - Lee, Mi Jung

AU - Han, SeungHyeok

AU - Kang, Shin-Wook

AU - Yoo, TaeHyun

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