Low normal TSH levels are associated with impaired BMD and hip geometry in the elderly

Su Jin Lee, Kyoung Min Kim, Eun Young Lee, Mi Kyung Song, Dae Ryong Kang, Hyeon Chang Kim, Yoosik Youm, Young Mi Yun, Hyun Young Park, Chang Oh Kim, Yumie Rhee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Subclinical hyperthyroidism is known to be associated with the risk of fractures in elderly people. However, there are few studies assessing whether low normal thyroid-stimulating hormone (TSH) levels affect bone density and geometry. Here, we aimed to assess the influence of the TSH level on bone mineral density (BMD) and geometry in elderly euthyroid subjects. This was a cross-sectional cohort study. A total of 343 men and 674 women with euthyroidism were included and analyzed separately. The subjects were divided into tertiles based on the serum TSH level. The BMD and geometry were measured using dual-energy X-ray absorptiometry and a hip structural analysis program. Multiple regression analysis was used to compute the odds ratios of osteoporosis in the lower TSH tertile group and the association between geometry parameters and the TSH level. We found that the femoral neck and total hip BMDs were lower in the lower TSH tertile group. In women, the cross-sectional area and cortical thickness of the femur were negatively associated with the TSH level in all three regions (the narrow neck, intertrochanter, and femoral shaft); however, in men, these geometry parameters were significantly associated with the TSH level only in the intertrochanter region. The buckling ratio, a bone geometry parameter representing cortical instability, was significantly higher in the lower TSH tertile group in all three regions in women, but not in men. Our results indicated that lower TSH levels in the euthyroid range are related to lower BMD and weaker femoral structure in elderly women.

Original languageEnglish
Pages (from-to)734-743
Number of pages10
JournalAging and Disease
Volume7
Issue number6
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Thyrotropin
Bone Density
Hip
Femur Neck
Photon Absorptiometry
Hyperthyroidism
Thigh
Femur
Osteoporosis
Cohort Studies
Cross-Sectional Studies
Odds Ratio
Regression Analysis
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cell Biology

Cite this

Lee, Su Jin ; Kim, Kyoung Min ; Lee, Eun Young ; Song, Mi Kyung ; Kang, Dae Ryong ; Kim, Hyeon Chang ; Youm, Yoosik ; Yun, Young Mi ; Park, Hyun Young ; Kim, Chang Oh ; Rhee, Yumie. / Low normal TSH levels are associated with impaired BMD and hip geometry in the elderly. In: Aging and Disease. 2016 ; Vol. 7, No. 6. pp. 734-743.
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abstract = "Subclinical hyperthyroidism is known to be associated with the risk of fractures in elderly people. However, there are few studies assessing whether low normal thyroid-stimulating hormone (TSH) levels affect bone density and geometry. Here, we aimed to assess the influence of the TSH level on bone mineral density (BMD) and geometry in elderly euthyroid subjects. This was a cross-sectional cohort study. A total of 343 men and 674 women with euthyroidism were included and analyzed separately. The subjects were divided into tertiles based on the serum TSH level. The BMD and geometry were measured using dual-energy X-ray absorptiometry and a hip structural analysis program. Multiple regression analysis was used to compute the odds ratios of osteoporosis in the lower TSH tertile group and the association between geometry parameters and the TSH level. We found that the femoral neck and total hip BMDs were lower in the lower TSH tertile group. In women, the cross-sectional area and cortical thickness of the femur were negatively associated with the TSH level in all three regions (the narrow neck, intertrochanter, and femoral shaft); however, in men, these geometry parameters were significantly associated with the TSH level only in the intertrochanter region. The buckling ratio, a bone geometry parameter representing cortical instability, was significantly higher in the lower TSH tertile group in all three regions in women, but not in men. Our results indicated that lower TSH levels in the euthyroid range are related to lower BMD and weaker femoral structure in elderly women.",
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Lee, SJ, Kim, KM, Lee, EY, Song, MK, Kang, DR, Kim, HC, Youm, Y, Yun, YM, Park, HY, Kim, CO & Rhee, Y 2016, 'Low normal TSH levels are associated with impaired BMD and hip geometry in the elderly', Aging and Disease, vol. 7, no. 6, pp. 734-743. https://doi.org/10.14336/AD.2016.0325

Low normal TSH levels are associated with impaired BMD and hip geometry in the elderly. / Lee, Su Jin; Kim, Kyoung Min; Lee, Eun Young; Song, Mi Kyung; Kang, Dae Ryong; Kim, Hyeon Chang; Youm, Yoosik; Yun, Young Mi; Park, Hyun Young; Kim, Chang Oh; Rhee, Yumie.

In: Aging and Disease, Vol. 7, No. 6, 01.01.2016, p. 734-743.

Research output: Contribution to journalArticle

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AU - Lee, Su Jin

AU - Kim, Kyoung Min

AU - Lee, Eun Young

AU - Song, Mi Kyung

AU - Kang, Dae Ryong

AU - Kim, Hyeon Chang

AU - Youm, Yoosik

AU - Yun, Young Mi

AU - Park, Hyun Young

AU - Kim, Chang Oh

AU - Rhee, Yumie

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N2 - Subclinical hyperthyroidism is known to be associated with the risk of fractures in elderly people. However, there are few studies assessing whether low normal thyroid-stimulating hormone (TSH) levels affect bone density and geometry. Here, we aimed to assess the influence of the TSH level on bone mineral density (BMD) and geometry in elderly euthyroid subjects. This was a cross-sectional cohort study. A total of 343 men and 674 women with euthyroidism were included and analyzed separately. The subjects were divided into tertiles based on the serum TSH level. The BMD and geometry were measured using dual-energy X-ray absorptiometry and a hip structural analysis program. Multiple regression analysis was used to compute the odds ratios of osteoporosis in the lower TSH tertile group and the association between geometry parameters and the TSH level. We found that the femoral neck and total hip BMDs were lower in the lower TSH tertile group. In women, the cross-sectional area and cortical thickness of the femur were negatively associated with the TSH level in all three regions (the narrow neck, intertrochanter, and femoral shaft); however, in men, these geometry parameters were significantly associated with the TSH level only in the intertrochanter region. The buckling ratio, a bone geometry parameter representing cortical instability, was significantly higher in the lower TSH tertile group in all three regions in women, but not in men. Our results indicated that lower TSH levels in the euthyroid range are related to lower BMD and weaker femoral structure in elderly women.

AB - Subclinical hyperthyroidism is known to be associated with the risk of fractures in elderly people. However, there are few studies assessing whether low normal thyroid-stimulating hormone (TSH) levels affect bone density and geometry. Here, we aimed to assess the influence of the TSH level on bone mineral density (BMD) and geometry in elderly euthyroid subjects. This was a cross-sectional cohort study. A total of 343 men and 674 women with euthyroidism were included and analyzed separately. The subjects were divided into tertiles based on the serum TSH level. The BMD and geometry were measured using dual-energy X-ray absorptiometry and a hip structural analysis program. Multiple regression analysis was used to compute the odds ratios of osteoporosis in the lower TSH tertile group and the association between geometry parameters and the TSH level. We found that the femoral neck and total hip BMDs were lower in the lower TSH tertile group. In women, the cross-sectional area and cortical thickness of the femur were negatively associated with the TSH level in all three regions (the narrow neck, intertrochanter, and femoral shaft); however, in men, these geometry parameters were significantly associated with the TSH level only in the intertrochanter region. The buckling ratio, a bone geometry parameter representing cortical instability, was significantly higher in the lower TSH tertile group in all three regions in women, but not in men. Our results indicated that lower TSH levels in the euthyroid range are related to lower BMD and weaker femoral structure in elderly women.

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