Low PR in ER(+)/HER2(−) breast cancer: High rates of TP53 mutation and high SUV

Sung Gwe Ahn, Chang Ik Yoon, Jae Hoon Lee, Hye Sun Lee, So Eun Park, Yoon Jin Cha, Chihwan Cha, Soong June Bae, Kyung A. Lee, Joon Jeong

Research output: Contribution to journalArticle

3 Citations (Scopus)


On the basis of TP53 mutations and standardized uptake values (SUVs) from 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET), we sought to enhance our knowledge of the biology underlying low progesterone receptor (PR) expression in estrogen receptor (ER)-positive/human epidermal growth factor receptor-2 (HER2)-negative tumors. This study included 272 patients surgically treated for ER-positive, HER2-negative breast cancer and who had undergone TP53 gene sequencing. Of these, 229 patients also underwent 18F-FDG PET or PET/CT. Mutational analysis of exons 5-9 of the TP53 gene was conducted using PCR amplification and direct sequencing. The SUVs were measured using 18F-FDG-PET scan images. Twenty-eight (10.3%) tumors had a somatic TP53 mutation. The TP53 mutation rate was significantly higher in low-PR tumors than in high-PR tumors (17.1% vs 7.9%, P = 0.039). Low-PR tumors had significantly higher median SUVs than high-PR tumors (P = 0.046). The multivariable analysis revealed that SUV and age remained independent variables associated with low PR expression. An adverse impact of low PR expression on recurrence-free survival was observed in the multivariable Cox regression hazard model. We provide clinical evidence that genetic alteration of the TP53 gene and dysregulated glucose metabolism partly involve low PR expression in ER-positive and HER2-negative breast cancer.

Original languageEnglish
Pages (from-to)177-185
Number of pages9
JournalEndocrine-Related Cancer
Issue number2
Publication statusPublished - 2019 Feb

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Oncology
  • Endocrinology
  • Cancer Research

Fingerprint Dive into the research topics of 'Low PR in ER(+)/HER2(−) breast cancer: High rates of TP53 mutation and high SUV'. Together they form a unique fingerprint.

  • Cite this

    Ahn, S. G., Yoon, C. I., Lee, J. H., Lee, H. S., Park, S. E., Cha, Y. J., Cha, C., Bae, S. J., Lee, K. A., & Jeong, J. (2019). Low PR in ER(+)/HER2(−) breast cancer: High rates of TP53 mutation and high SUV. Endocrine-Related Cancer, 26(2), 177-185. https://doi.org/10.1530/ERC-18-0281