Low serum vitamin D is associated with high risk of diabetes in Korean adults

Han Seok Choi, Kyoung Ah Kim, Chi Yeon Lim, Sang Youl Rhee, You Cheol Hwang, Kyoung Min Kim, Kwang Joon Kim, Yumie Rhee, Sung Kil Lim

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Vitamin D may play a role in glucose metabolism. A low vitamin D level has been associated with increased risk of diabetes mellitus, but the association has not been confirmed in Asians. Our objective was to examine the association of serum 25-hydroxyvitamin D [25(OH)D] levels with insulin resistance and diabetes mellitus in Korean adults based on a large population-based survey. Cross-sectional analyses were carried out on 5787 Korean adults (2453 men and 3334 women) who were 20 y or older and participated in the Fourth Korea NHANES conducted in 2008. Diabetes mellitus was defined as fasting plasma glucose ≥7 mmol/L or current use of oral hypoglycemic agents or insulin. Insulin resistance was estimated by homeostatic model assessment for insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI). Compared to individuals with a sufficient serum 25(OH)D concentration ≥75 nmol/L, the OR (95% CI) for diabetes mellitus were 1.73 (1.09-2.74), 1.30 (0.91-1.84), and 1.40 (0.99-1.98) for serum 25(OH)D concentrations,25, 25 to,50, and 50 to ≥75 nmol/L, respectively, after multiple adjustments (P-trend, 0.0001). Furthermore, the serum 25(OH)D level was inversely associated with HOMA-IR (β = 20.061; P = 0.001) and positively associated with QUICKI (β = 0.059; P = 0.001) in overweight or obese participants. In conclusion, a low serum vitamin D concentration is associated with a high risk of diabetes mellitus in Korean adults and the concentration is inversely associated with insulin resistance in those who are overweight or obese.

Original languageEnglish
Pages (from-to)1524-1528
Number of pages5
JournalJournal of Nutrition
Volume141
Issue number8
DOIs
Publication statusPublished - 2011 Aug 1

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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