Low serum vitamin D is associated with high risk of diabetes in Korean adults

Han Seok Choi, Kyoung Ah Kim, Chi Yeon Lim, Sang Youl Rhee, You Cheol Hwang, Kyoung Min Kim, Kwang Joon Kim, Yumie Rhee, Sung Kil Lim

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Vitamin D may play a role in glucose metabolism. A low vitamin D level has been associated with increased risk of diabetes mellitus, but the association has not been confirmed in Asians. Our objective was to examine the association of serum 25-hydroxyvitamin D [25(OH)D] levels with insulin resistance and diabetes mellitus in Korean adults based on a large population-based survey. Cross-sectional analyses were carried out on 5787 Korean adults (2453 men and 3334 women) who were 20 y or older and participated in the Fourth Korea NHANES conducted in 2008. Diabetes mellitus was defined as fasting plasma glucose ≥7 mmol/L or current use of oral hypoglycemic agents or insulin. Insulin resistance was estimated by homeostatic model assessment for insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI). Compared to individuals with a sufficient serum 25(OH)D concentration ≥75 nmol/L, the OR (95% CI) for diabetes mellitus were 1.73 (1.09-2.74), 1.30 (0.91-1.84), and 1.40 (0.99-1.98) for serum 25(OH)D concentrations,25, 25 to,50, and 50 to ≥75 nmol/L, respectively, after multiple adjustments (P-trend, 0.0001). Furthermore, the serum 25(OH)D level was inversely associated with HOMA-IR (β = 20.061; P = 0.001) and positively associated with QUICKI (β = 0.059; P = 0.001) in overweight or obese participants. In conclusion, a low serum vitamin D concentration is associated with a high risk of diabetes mellitus in Korean adults and the concentration is inversely associated with insulin resistance in those who are overweight or obese.

Original languageEnglish
Pages (from-to)1524-1528
Number of pages5
JournalJournal of Nutrition
Volume141
Issue number8
DOIs
Publication statusPublished - 2011 Aug 1

Fingerprint

Vitamin D
Insulin Resistance
Diabetes Mellitus
Serum
Social Adjustment
Glucose
Nutrition Surveys
Korea
Hypoglycemic Agents
Fasting
Cross-Sectional Studies
Insulin
Population

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Choi, H. S., Kim, K. A., Lim, C. Y., Rhee, S. Y., Hwang, Y. C., Kim, K. M., ... Lim, S. K. (2011). Low serum vitamin D is associated with high risk of diabetes in Korean adults. Journal of Nutrition, 141(8), 1524-1528. https://doi.org/10.3945/jn.111.139121
Choi, Han Seok ; Kim, Kyoung Ah ; Lim, Chi Yeon ; Rhee, Sang Youl ; Hwang, You Cheol ; Kim, Kyoung Min ; Kim, Kwang Joon ; Rhee, Yumie ; Lim, Sung Kil. / Low serum vitamin D is associated with high risk of diabetes in Korean adults. In: Journal of Nutrition. 2011 ; Vol. 141, No. 8. pp. 1524-1528.
@article{e6c6a6321a374994a692dc51d7b0af7e,
title = "Low serum vitamin D is associated with high risk of diabetes in Korean adults",
abstract = "Vitamin D may play a role in glucose metabolism. A low vitamin D level has been associated with increased risk of diabetes mellitus, but the association has not been confirmed in Asians. Our objective was to examine the association of serum 25-hydroxyvitamin D [25(OH)D] levels with insulin resistance and diabetes mellitus in Korean adults based on a large population-based survey. Cross-sectional analyses were carried out on 5787 Korean adults (2453 men and 3334 women) who were 20 y or older and participated in the Fourth Korea NHANES conducted in 2008. Diabetes mellitus was defined as fasting plasma glucose ≥7 mmol/L or current use of oral hypoglycemic agents or insulin. Insulin resistance was estimated by homeostatic model assessment for insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI). Compared to individuals with a sufficient serum 25(OH)D concentration ≥75 nmol/L, the OR (95{\%} CI) for diabetes mellitus were 1.73 (1.09-2.74), 1.30 (0.91-1.84), and 1.40 (0.99-1.98) for serum 25(OH)D concentrations,25, 25 to,50, and 50 to ≥75 nmol/L, respectively, after multiple adjustments (P-trend, 0.0001). Furthermore, the serum 25(OH)D level was inversely associated with HOMA-IR (β = 20.061; P = 0.001) and positively associated with QUICKI (β = 0.059; P = 0.001) in overweight or obese participants. In conclusion, a low serum vitamin D concentration is associated with a high risk of diabetes mellitus in Korean adults and the concentration is inversely associated with insulin resistance in those who are overweight or obese.",
author = "Choi, {Han Seok} and Kim, {Kyoung Ah} and Lim, {Chi Yeon} and Rhee, {Sang Youl} and Hwang, {You Cheol} and Kim, {Kyoung Min} and Kim, {Kwang Joon} and Yumie Rhee and Lim, {Sung Kil}",
year = "2011",
month = "8",
day = "1",
doi = "10.3945/jn.111.139121",
language = "English",
volume = "141",
pages = "1524--1528",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "8",

}

Choi, HS, Kim, KA, Lim, CY, Rhee, SY, Hwang, YC, Kim, KM, Kim, KJ, Rhee, Y & Lim, SK 2011, 'Low serum vitamin D is associated with high risk of diabetes in Korean adults', Journal of Nutrition, vol. 141, no. 8, pp. 1524-1528. https://doi.org/10.3945/jn.111.139121

Low serum vitamin D is associated with high risk of diabetes in Korean adults. / Choi, Han Seok; Kim, Kyoung Ah; Lim, Chi Yeon; Rhee, Sang Youl; Hwang, You Cheol; Kim, Kyoung Min; Kim, Kwang Joon; Rhee, Yumie; Lim, Sung Kil.

In: Journal of Nutrition, Vol. 141, No. 8, 01.08.2011, p. 1524-1528.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Low serum vitamin D is associated with high risk of diabetes in Korean adults

AU - Choi, Han Seok

AU - Kim, Kyoung Ah

AU - Lim, Chi Yeon

AU - Rhee, Sang Youl

AU - Hwang, You Cheol

AU - Kim, Kyoung Min

AU - Kim, Kwang Joon

AU - Rhee, Yumie

AU - Lim, Sung Kil

PY - 2011/8/1

Y1 - 2011/8/1

N2 - Vitamin D may play a role in glucose metabolism. A low vitamin D level has been associated with increased risk of diabetes mellitus, but the association has not been confirmed in Asians. Our objective was to examine the association of serum 25-hydroxyvitamin D [25(OH)D] levels with insulin resistance and diabetes mellitus in Korean adults based on a large population-based survey. Cross-sectional analyses were carried out on 5787 Korean adults (2453 men and 3334 women) who were 20 y or older and participated in the Fourth Korea NHANES conducted in 2008. Diabetes mellitus was defined as fasting plasma glucose ≥7 mmol/L or current use of oral hypoglycemic agents or insulin. Insulin resistance was estimated by homeostatic model assessment for insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI). Compared to individuals with a sufficient serum 25(OH)D concentration ≥75 nmol/L, the OR (95% CI) for diabetes mellitus were 1.73 (1.09-2.74), 1.30 (0.91-1.84), and 1.40 (0.99-1.98) for serum 25(OH)D concentrations,25, 25 to,50, and 50 to ≥75 nmol/L, respectively, after multiple adjustments (P-trend, 0.0001). Furthermore, the serum 25(OH)D level was inversely associated with HOMA-IR (β = 20.061; P = 0.001) and positively associated with QUICKI (β = 0.059; P = 0.001) in overweight or obese participants. In conclusion, a low serum vitamin D concentration is associated with a high risk of diabetes mellitus in Korean adults and the concentration is inversely associated with insulin resistance in those who are overweight or obese.

AB - Vitamin D may play a role in glucose metabolism. A low vitamin D level has been associated with increased risk of diabetes mellitus, but the association has not been confirmed in Asians. Our objective was to examine the association of serum 25-hydroxyvitamin D [25(OH)D] levels with insulin resistance and diabetes mellitus in Korean adults based on a large population-based survey. Cross-sectional analyses were carried out on 5787 Korean adults (2453 men and 3334 women) who were 20 y or older and participated in the Fourth Korea NHANES conducted in 2008. Diabetes mellitus was defined as fasting plasma glucose ≥7 mmol/L or current use of oral hypoglycemic agents or insulin. Insulin resistance was estimated by homeostatic model assessment for insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI). Compared to individuals with a sufficient serum 25(OH)D concentration ≥75 nmol/L, the OR (95% CI) for diabetes mellitus were 1.73 (1.09-2.74), 1.30 (0.91-1.84), and 1.40 (0.99-1.98) for serum 25(OH)D concentrations,25, 25 to,50, and 50 to ≥75 nmol/L, respectively, after multiple adjustments (P-trend, 0.0001). Furthermore, the serum 25(OH)D level was inversely associated with HOMA-IR (β = 20.061; P = 0.001) and positively associated with QUICKI (β = 0.059; P = 0.001) in overweight or obese participants. In conclusion, a low serum vitamin D concentration is associated with a high risk of diabetes mellitus in Korean adults and the concentration is inversely associated with insulin resistance in those who are overweight or obese.

UR - http://www.scopus.com/inward/record.url?scp=79961110919&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79961110919&partnerID=8YFLogxK

U2 - 10.3945/jn.111.139121

DO - 10.3945/jn.111.139121

M3 - Article

C2 - 21697301

AN - SCOPUS:79961110919

VL - 141

SP - 1524

EP - 1528

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 8

ER -

Choi HS, Kim KA, Lim CY, Rhee SY, Hwang YC, Kim KM et al. Low serum vitamin D is associated with high risk of diabetes in Korean adults. Journal of Nutrition. 2011 Aug 1;141(8):1524-1528. https://doi.org/10.3945/jn.111.139121