Low trans structured fat from flaxseed oil improves plasma and hepatic lipid metabolism in apo E-/- mice

Yun Young Cho, Eun Young Kwon, Hye Jin Kim, Yong Bok Park, Ki Teak Lee, Taesun Park, Myung Sook Choi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The objective of this study was to explicate the effects of feeding low trans structured fat from flaxseed oil (LF) on plasma and hepatic lipid metabolism involved in apo E-/- mice. The animals were fed a commercial shortening (CS), commercial low trans fat (CL) and LF diet based on AIN-76 diet (10% fat) for 12 weeks. LF supplementation exerted a significant suppression in hepatic lipid accumulation with the concomitant decrease in liver weight. The LF significantly lowered plasma total cholesterol and free fatty acid whereas it significantly increased HDL-C concentration and the HDL-C/total-C ratio compared to the CS group. Reduction of hepatic lipid levels in the LF group was related with the suppression of hepatic enzyme activities for fatty acid and triglyceride synthesis, and cholesterol regulating enzyme activity compared to the CS and CL groups. Accordingly, low trans structured fat from flaxseed oil is highly effective for improving hyperlipidemia and hepatic lipid accumulation in apo E-/- mice.

Original languageEnglish
Pages (from-to)1550-1555
Number of pages6
JournalFood and Chemical Toxicology
Volume47
Issue number7
DOIs
Publication statusPublished - 2009 Jul 1

Fingerprint

Linseed Oil
linseed oil
Apolipoproteins E
Lipid Metabolism
lipid metabolism
Fats
Plasmas
liver
Liver
mice
Enzyme activity
Nutrition
lipids
Lipids
shortenings
Cholesterol
Nonesterified Fatty Acids
Diet
cholesterol
Animals

All Science Journal Classification (ASJC) codes

  • Food Science
  • Toxicology

Cite this

Cho, Yun Young ; Kwon, Eun Young ; Kim, Hye Jin ; Park, Yong Bok ; Lee, Ki Teak ; Park, Taesun ; Choi, Myung Sook. / Low trans structured fat from flaxseed oil improves plasma and hepatic lipid metabolism in apo E-/- mice. In: Food and Chemical Toxicology. 2009 ; Vol. 47, No. 7. pp. 1550-1555.
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Low trans structured fat from flaxseed oil improves plasma and hepatic lipid metabolism in apo E-/- mice. / Cho, Yun Young; Kwon, Eun Young; Kim, Hye Jin; Park, Yong Bok; Lee, Ki Teak; Park, Taesun; Choi, Myung Sook.

In: Food and Chemical Toxicology, Vol. 47, No. 7, 01.07.2009, p. 1550-1555.

Research output: Contribution to journalArticle

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