Lower bone mineral density is associated with higher coronary calcification and coronary plaque burdens by multidetector row coronary computed tomography in pre- and postmenopausal women

Sung Hee Choi, Jee Hyun An, Soo Lim, Bo Kyung Koo, Se Eun Park, Hyuk-Jae Chang, Sang Il Choi, Young Joo Park, Kyong Soo Park, Hak Chul Jang, Chan Soo Shin

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Abstract

Objectives There is growing evidence for the association between bone mineral density (BMD) and vascular calcification, which is related to cardiovascular disease. Coronary multidetector row computed tomography (MDCT) is a noninvasive tool developed to evaluate coronary status precisely. We used MDCT to evaluate this association. Design and patients Eight hundred and fifteen subjects received routine checkups. After excluding subjects with factors affecting bone metabolism and cardiovascular disease, 467 subjects were analysed. Measurements Coronary calcification was measured with MDCT and BMD was measured with dual X-ray absorptiometry (DXA). Results The BMD of the femur and the lumbar spine (L-spine) were negatively associated with the coronary calcium score (CCS) after adjusting for age in women but not in men. This inverse correlation was stronger in women with a longer time since menopause (r = -0·35 at femur, postmenopausal women vs. r = -0·10 at femur, premenopausal women, P < 0·05), and it was stronger at the femur than in the L-spine (r = -0·35 at femur vs. r = -0·16 at L-spine, P < 0·01). The relationship was also stronger in postmenopausal women with osteoporosis and osteopaenia than in women with normal BMD. The lower BMD was associated with higher coronary plaque burdens and multidiseased coronary vessels in both men and women (P < 0·01). Conclusions Increased CCS and subclinical atherosclerosis of plaque burdens as revealed by MDCT was associated with a low BMD in all women, independent of cardiovascular risk factors and age.

Original languageEnglish
Pages (from-to)644-651
Number of pages8
JournalClinical Endocrinology
Volume71
Issue number5
DOIs
Publication statusPublished - 2009 Nov 1

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Multidetector Computed Tomography
Bone Density
Femur
Spine
Cardiovascular Diseases
Calcium
Vascular Calcification
Bone Diseases
Photon Absorptiometry
Menopause
Osteoporosis
Atherosclerosis
Coronary Vessels

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Choi, Sung Hee ; An, Jee Hyun ; Lim, Soo ; Koo, Bo Kyung ; Park, Se Eun ; Chang, Hyuk-Jae ; Choi, Sang Il ; Park, Young Joo ; Park, Kyong Soo ; Jang, Hak Chul ; Shin, Chan Soo. / Lower bone mineral density is associated with higher coronary calcification and coronary plaque burdens by multidetector row coronary computed tomography in pre- and postmenopausal women. In: Clinical Endocrinology. 2009 ; Vol. 71, No. 5. pp. 644-651.
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abstract = "Objectives There is growing evidence for the association between bone mineral density (BMD) and vascular calcification, which is related to cardiovascular disease. Coronary multidetector row computed tomography (MDCT) is a noninvasive tool developed to evaluate coronary status precisely. We used MDCT to evaluate this association. Design and patients Eight hundred and fifteen subjects received routine checkups. After excluding subjects with factors affecting bone metabolism and cardiovascular disease, 467 subjects were analysed. Measurements Coronary calcification was measured with MDCT and BMD was measured with dual X-ray absorptiometry (DXA). Results The BMD of the femur and the lumbar spine (L-spine) were negatively associated with the coronary calcium score (CCS) after adjusting for age in women but not in men. This inverse correlation was stronger in women with a longer time since menopause (r = -0·35 at femur, postmenopausal women vs. r = -0·10 at femur, premenopausal women, P < 0·05), and it was stronger at the femur than in the L-spine (r = -0·35 at femur vs. r = -0·16 at L-spine, P < 0·01). The relationship was also stronger in postmenopausal women with osteoporosis and osteopaenia than in women with normal BMD. The lower BMD was associated with higher coronary plaque burdens and multidiseased coronary vessels in both men and women (P < 0·01). Conclusions Increased CCS and subclinical atherosclerosis of plaque burdens as revealed by MDCT was associated with a low BMD in all women, independent of cardiovascular risk factors and age.",
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Lower bone mineral density is associated with higher coronary calcification and coronary plaque burdens by multidetector row coronary computed tomography in pre- and postmenopausal women. / Choi, Sung Hee; An, Jee Hyun; Lim, Soo; Koo, Bo Kyung; Park, Se Eun; Chang, Hyuk-Jae; Choi, Sang Il; Park, Young Joo; Park, Kyong Soo; Jang, Hak Chul; Shin, Chan Soo.

In: Clinical Endocrinology, Vol. 71, No. 5, 01.11.2009, p. 644-651.

Research output: Contribution to journalArticle

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T1 - Lower bone mineral density is associated with higher coronary calcification and coronary plaque burdens by multidetector row coronary computed tomography in pre- and postmenopausal women

AU - Choi, Sung Hee

AU - An, Jee Hyun

AU - Lim, Soo

AU - Koo, Bo Kyung

AU - Park, Se Eun

AU - Chang, Hyuk-Jae

AU - Choi, Sang Il

AU - Park, Young Joo

AU - Park, Kyong Soo

AU - Jang, Hak Chul

AU - Shin, Chan Soo

PY - 2009/11/1

Y1 - 2009/11/1

N2 - Objectives There is growing evidence for the association between bone mineral density (BMD) and vascular calcification, which is related to cardiovascular disease. Coronary multidetector row computed tomography (MDCT) is a noninvasive tool developed to evaluate coronary status precisely. We used MDCT to evaluate this association. Design and patients Eight hundred and fifteen subjects received routine checkups. After excluding subjects with factors affecting bone metabolism and cardiovascular disease, 467 subjects were analysed. Measurements Coronary calcification was measured with MDCT and BMD was measured with dual X-ray absorptiometry (DXA). Results The BMD of the femur and the lumbar spine (L-spine) were negatively associated with the coronary calcium score (CCS) after adjusting for age in women but not in men. This inverse correlation was stronger in women with a longer time since menopause (r = -0·35 at femur, postmenopausal women vs. r = -0·10 at femur, premenopausal women, P < 0·05), and it was stronger at the femur than in the L-spine (r = -0·35 at femur vs. r = -0·16 at L-spine, P < 0·01). The relationship was also stronger in postmenopausal women with osteoporosis and osteopaenia than in women with normal BMD. The lower BMD was associated with higher coronary plaque burdens and multidiseased coronary vessels in both men and women (P < 0·01). Conclusions Increased CCS and subclinical atherosclerosis of plaque burdens as revealed by MDCT was associated with a low BMD in all women, independent of cardiovascular risk factors and age.

AB - Objectives There is growing evidence for the association between bone mineral density (BMD) and vascular calcification, which is related to cardiovascular disease. Coronary multidetector row computed tomography (MDCT) is a noninvasive tool developed to evaluate coronary status precisely. We used MDCT to evaluate this association. Design and patients Eight hundred and fifteen subjects received routine checkups. After excluding subjects with factors affecting bone metabolism and cardiovascular disease, 467 subjects were analysed. Measurements Coronary calcification was measured with MDCT and BMD was measured with dual X-ray absorptiometry (DXA). Results The BMD of the femur and the lumbar spine (L-spine) were negatively associated with the coronary calcium score (CCS) after adjusting for age in women but not in men. This inverse correlation was stronger in women with a longer time since menopause (r = -0·35 at femur, postmenopausal women vs. r = -0·10 at femur, premenopausal women, P < 0·05), and it was stronger at the femur than in the L-spine (r = -0·35 at femur vs. r = -0·16 at L-spine, P < 0·01). The relationship was also stronger in postmenopausal women with osteoporosis and osteopaenia than in women with normal BMD. The lower BMD was associated with higher coronary plaque burdens and multidiseased coronary vessels in both men and women (P < 0·01). Conclusions Increased CCS and subclinical atherosclerosis of plaque burdens as revealed by MDCT was associated with a low BMD in all women, independent of cardiovascular risk factors and age.

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