Lowering prostate-specific antigen threshold for prostate biopsy in Korean men: Impact on the number needing biopsy

Jin Seon Cho, Sun Il Kim, Se Joong Kim, Young Sig Kim, Chun Il Kim, Hong Sup Kim, Do Hwan Seong, Yun Seob Song, Dong Hyeon Lee, Won Jae Yang, Sang Hyeon Cheon, Kang Su Cho, In Rae Cho, Byungha Chung, Youngdeuk Choi, Hyoungjune Im, Sung Joon Hong

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: We examined the effect of lowering prostate-specific antigen (PSA) threshold on the number of Korean men requiring a prostate biopsy. Materials and methods: We evaluated men who had serum PSA levels tested at routine physical check-ups between 1999 and 2005 at 11 domestic hospitals. Men with PSA ≥ 10ng/ml or patients with prostate cancer were excluded. A total of 45,074 men (aged 50 to 79 years) were enrolled and split into three age groups: 50-59 years, 60-69 years, and 70-79 years. For each age group, we calculated the number and proportion of men whose PSA level exceeded potential biopsy thresholds: 2.5ng/ml, 3.0ng/ml, and 4.0ng/ml. Results were extrapolated to the 4.992 million men older than 50 years old, or 21.3% of the Korean male population in 2005. Results: The number of biopsy candidates at the threshold of 4.0ng/ ml, 3.0ng/ml, and 2.5ng/ml were 1,321 (2.9%), 2,248 (5.4%), and 3,577 (7.9%), respectively. Extrapolating to the male population in Korea, lowering the PSA threshold from 4.0ng/ml to 3.0 or 2.5ng/ml would increase the number of men needing biopsy by 1.75 and 2.49 times, respectively. Conclusions: Lowering the PSA threshold would increase the number of men receiving prostate biopsy despite the low reference age for PSA in Korea. Considering the low incidence of prostate cancer, physicians should be careful in altering the PSA threshold.

Original languageEnglish
Pages (from-to)118-121
Number of pages4
JournalKorean Journal of Urology
Volume49
Issue number2
DOIs
Publication statusPublished - 2008 Jan 1

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Prostate-Specific Antigen
Prostate
Biopsy
Korea
Prostatic Neoplasms
Age Groups
Population
Physicians
Incidence
Serum

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Cho, Jin Seon ; Kim, Sun Il ; Kim, Se Joong ; Kim, Young Sig ; Kim, Chun Il ; Kim, Hong Sup ; Seong, Do Hwan ; Song, Yun Seob ; Lee, Dong Hyeon ; Yang, Won Jae ; Cheon, Sang Hyeon ; Cho, Kang Su ; Cho, In Rae ; Chung, Byungha ; Choi, Youngdeuk ; Im, Hyoungjune ; Hong, Sung Joon. / Lowering prostate-specific antigen threshold for prostate biopsy in Korean men : Impact on the number needing biopsy. In: Korean Journal of Urology. 2008 ; Vol. 49, No. 2. pp. 118-121.
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title = "Lowering prostate-specific antigen threshold for prostate biopsy in Korean men: Impact on the number needing biopsy",
abstract = "Purpose: We examined the effect of lowering prostate-specific antigen (PSA) threshold on the number of Korean men requiring a prostate biopsy. Materials and methods: We evaluated men who had serum PSA levels tested at routine physical check-ups between 1999 and 2005 at 11 domestic hospitals. Men with PSA ≥ 10ng/ml or patients with prostate cancer were excluded. A total of 45,074 men (aged 50 to 79 years) were enrolled and split into three age groups: 50-59 years, 60-69 years, and 70-79 years. For each age group, we calculated the number and proportion of men whose PSA level exceeded potential biopsy thresholds: 2.5ng/ml, 3.0ng/ml, and 4.0ng/ml. Results were extrapolated to the 4.992 million men older than 50 years old, or 21.3{\%} of the Korean male population in 2005. Results: The number of biopsy candidates at the threshold of 4.0ng/ ml, 3.0ng/ml, and 2.5ng/ml were 1,321 (2.9{\%}), 2,248 (5.4{\%}), and 3,577 (7.9{\%}), respectively. Extrapolating to the male population in Korea, lowering the PSA threshold from 4.0ng/ml to 3.0 or 2.5ng/ml would increase the number of men needing biopsy by 1.75 and 2.49 times, respectively. Conclusions: Lowering the PSA threshold would increase the number of men receiving prostate biopsy despite the low reference age for PSA in Korea. Considering the low incidence of prostate cancer, physicians should be careful in altering the PSA threshold.",
author = "Cho, {Jin Seon} and Kim, {Sun Il} and Kim, {Se Joong} and Kim, {Young Sig} and Kim, {Chun Il} and Kim, {Hong Sup} and Seong, {Do Hwan} and Song, {Yun Seob} and Lee, {Dong Hyeon} and Yang, {Won Jae} and Cheon, {Sang Hyeon} and Cho, {Kang Su} and Cho, {In Rae} and Byungha Chung and Youngdeuk Choi and Hyoungjune Im and Hong, {Sung Joon}",
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Cho, JS, Kim, SI, Kim, SJ, Kim, YS, Kim, CI, Kim, HS, Seong, DH, Song, YS, Lee, DH, Yang, WJ, Cheon, SH, Cho, KS, Cho, IR, Chung, B, Choi, Y, Im, H & Hong, SJ 2008, 'Lowering prostate-specific antigen threshold for prostate biopsy in Korean men: Impact on the number needing biopsy', Korean Journal of Urology, vol. 49, no. 2, pp. 118-121. https://doi.org/10.4111/kju.2008.49.2.118

Lowering prostate-specific antigen threshold for prostate biopsy in Korean men : Impact on the number needing biopsy. / Cho, Jin Seon; Kim, Sun Il; Kim, Se Joong; Kim, Young Sig; Kim, Chun Il; Kim, Hong Sup; Seong, Do Hwan; Song, Yun Seob; Lee, Dong Hyeon; Yang, Won Jae; Cheon, Sang Hyeon; Cho, Kang Su; Cho, In Rae; Chung, Byungha; Choi, Youngdeuk; Im, Hyoungjune; Hong, Sung Joon.

In: Korean Journal of Urology, Vol. 49, No. 2, 01.01.2008, p. 118-121.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Lowering prostate-specific antigen threshold for prostate biopsy in Korean men

T2 - Impact on the number needing biopsy

AU - Cho, Jin Seon

AU - Kim, Sun Il

AU - Kim, Se Joong

AU - Kim, Young Sig

AU - Kim, Chun Il

AU - Kim, Hong Sup

AU - Seong, Do Hwan

AU - Song, Yun Seob

AU - Lee, Dong Hyeon

AU - Yang, Won Jae

AU - Cheon, Sang Hyeon

AU - Cho, Kang Su

AU - Cho, In Rae

AU - Chung, Byungha

AU - Choi, Youngdeuk

AU - Im, Hyoungjune

AU - Hong, Sung Joon

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Purpose: We examined the effect of lowering prostate-specific antigen (PSA) threshold on the number of Korean men requiring a prostate biopsy. Materials and methods: We evaluated men who had serum PSA levels tested at routine physical check-ups between 1999 and 2005 at 11 domestic hospitals. Men with PSA ≥ 10ng/ml or patients with prostate cancer were excluded. A total of 45,074 men (aged 50 to 79 years) were enrolled and split into three age groups: 50-59 years, 60-69 years, and 70-79 years. For each age group, we calculated the number and proportion of men whose PSA level exceeded potential biopsy thresholds: 2.5ng/ml, 3.0ng/ml, and 4.0ng/ml. Results were extrapolated to the 4.992 million men older than 50 years old, or 21.3% of the Korean male population in 2005. Results: The number of biopsy candidates at the threshold of 4.0ng/ ml, 3.0ng/ml, and 2.5ng/ml were 1,321 (2.9%), 2,248 (5.4%), and 3,577 (7.9%), respectively. Extrapolating to the male population in Korea, lowering the PSA threshold from 4.0ng/ml to 3.0 or 2.5ng/ml would increase the number of men needing biopsy by 1.75 and 2.49 times, respectively. Conclusions: Lowering the PSA threshold would increase the number of men receiving prostate biopsy despite the low reference age for PSA in Korea. Considering the low incidence of prostate cancer, physicians should be careful in altering the PSA threshold.

AB - Purpose: We examined the effect of lowering prostate-specific antigen (PSA) threshold on the number of Korean men requiring a prostate biopsy. Materials and methods: We evaluated men who had serum PSA levels tested at routine physical check-ups between 1999 and 2005 at 11 domestic hospitals. Men with PSA ≥ 10ng/ml or patients with prostate cancer were excluded. A total of 45,074 men (aged 50 to 79 years) were enrolled and split into three age groups: 50-59 years, 60-69 years, and 70-79 years. For each age group, we calculated the number and proportion of men whose PSA level exceeded potential biopsy thresholds: 2.5ng/ml, 3.0ng/ml, and 4.0ng/ml. Results were extrapolated to the 4.992 million men older than 50 years old, or 21.3% of the Korean male population in 2005. Results: The number of biopsy candidates at the threshold of 4.0ng/ ml, 3.0ng/ml, and 2.5ng/ml were 1,321 (2.9%), 2,248 (5.4%), and 3,577 (7.9%), respectively. Extrapolating to the male population in Korea, lowering the PSA threshold from 4.0ng/ml to 3.0 or 2.5ng/ml would increase the number of men needing biopsy by 1.75 and 2.49 times, respectively. Conclusions: Lowering the PSA threshold would increase the number of men receiving prostate biopsy despite the low reference age for PSA in Korea. Considering the low incidence of prostate cancer, physicians should be careful in altering the PSA threshold.

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JO - Korean Journal of Urology

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