Lupus miliaris disseminatus faciei associated with milium

Min Ju Choi, Jimyung Seo, Sang Ho Oh, Young Kim Do

Research output: Contribution to journalArticle

Abstract

Lupus miliaris disseminatus faciei (LMDF) is a chronic inflammatory disorder primarily affecting the face. A 22-year-old man presented with facial skin lesions. Physical examination revealed scattered pin-head sized erythematous to yellowish papules. Skin biopsy from the erythematous papule showed keratinous material in the layers of the thin epithelium and caseous necrosis with adjacent epitheloid granuloma and giant cells. After mechanical extractions of milium-like inflamed papules, skin lesions improved leaving an atrophic scar. LMDF was initially thought to be associated with tuberculosis infection but today it is considered a variant of rosacea. However, there have been reports of LMDF in association with epidermal cysts or milium, suggesting an abnormal immune response to the pilosebaceous unit may play a role. Damage to the pilosebaceous unit that is further complicated by milium rupture may induce inflammation resulting in LMDF. We suggest that milium or epidermal cysts may also attribute to the pathogenesis of LMDF although further studies are needed.

Original languageEnglish
Pages (from-to)638-641
Number of pages4
JournalKorean Journal of Dermatology
Volume52
Issue number9
Publication statusPublished - 2014 Jan 1

Fingerprint

Epidermal Cyst
Skin
Giant Cell Granuloma
Rosacea
Physical Examination
Cicatrix
Rupture
Tuberculosis
Necrosis
Epithelium
Head
Inflammation
Biopsy
Infection

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Choi, Min Ju ; Seo, Jimyung ; Oh, Sang Ho ; Do, Young Kim. / Lupus miliaris disseminatus faciei associated with milium. In: Korean Journal of Dermatology. 2014 ; Vol. 52, No. 9. pp. 638-641.
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Choi, MJ, Seo, J, Oh, SH & Do, YK 2014, 'Lupus miliaris disseminatus faciei associated with milium', Korean Journal of Dermatology, vol. 52, no. 9, pp. 638-641.

Lupus miliaris disseminatus faciei associated with milium. / Choi, Min Ju; Seo, Jimyung; Oh, Sang Ho; Do, Young Kim.

In: Korean Journal of Dermatology, Vol. 52, No. 9, 01.01.2014, p. 638-641.

Research output: Contribution to journalArticle

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AB - Lupus miliaris disseminatus faciei (LMDF) is a chronic inflammatory disorder primarily affecting the face. A 22-year-old man presented with facial skin lesions. Physical examination revealed scattered pin-head sized erythematous to yellowish papules. Skin biopsy from the erythematous papule showed keratinous material in the layers of the thin epithelium and caseous necrosis with adjacent epitheloid granuloma and giant cells. After mechanical extractions of milium-like inflamed papules, skin lesions improved leaving an atrophic scar. LMDF was initially thought to be associated with tuberculosis infection but today it is considered a variant of rosacea. However, there have been reports of LMDF in association with epidermal cysts or milium, suggesting an abnormal immune response to the pilosebaceous unit may play a role. Damage to the pilosebaceous unit that is further complicated by milium rupture may induce inflammation resulting in LMDF. We suggest that milium or epidermal cysts may also attribute to the pathogenesis of LMDF although further studies are needed.

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