Lycopene Inhibits IL-6 Expression by Upregulating NQO1 and HO-1 via Activation of Nrf2 in Ethanol/Lipopolysaccharide-Stimulated Pancreatic Acinar Cells

Agriculture & Biology

• heme oxygenase (biliverdin-producing) 100%
• acinar cells 88%
• lycopene 79%
• interleukin-6 77%
• lipopolysaccharides 67%
• reactive oxygen species 58%
• ethanol 49%
• pancreatitis 34%
• alcohol abuse 25%
• inflammation 21%
• NAD(P)H dehydrogenase (quinone) 15%
• palmitoleic acid 15%
• NAD(P)H oxidase (H2O2-forming) 14%
• endotoxins 13%
• cytokines 11%
• permeability 9%
• alcohols 9%
• digestive system 9%
• oxidative stress 9%
• cytoplasm 9%
• antioxidants 7%
• cells 7%

Medicine & Life Sciences

• Lycopene 96%
• Acinar Cells 83%
• Heme Oxygenase-1 82%
• Lipopolysaccharides 60%
• Ethanol 59%
• Reactive Oxygen Species 56%
• Interleukin-6 54%
• Alcoholic Pancreatitis 35%
• palmitoleic acid 18%
• quinone 14%
• Inflammation 13%
• NADPH Oxidases 13%
• NAD 12%
• Endotoxins 11%
• Oxidoreductases 10%
• Permeability 10%
• Cytoplasm 9%
• Alcohols 8%
• Antioxidants 8%
• Anti-Inflammatory Agents 8%
• Oxidative Stress 8%
• Up-Regulation 8%
• Food 8%
• Cytokines 7%

Chemistry

• Lycopene 99%
• Reactive Oxygen Metabolite 66%
• Heme 65%
• Lipopolysaccharide 46%
• Ethanol 45%
• Cytoprotective 19%
• NAD(P)H 18%
• Endotoxin 18%
• Oxidative Stress 13%
• Antiinflammatory 13%
• Quinone 13%
• Antioxidant Agent 10%
• Food 10%
• Alcohol 8%
• Dioxygen 6%
• Amount 6%
• Protein 5%