Lycopene inhibits reactive oxygen species-mediated nf-kb signaling and induces apoptosis in pancreatic cancer cells

Yoonseon Jeong, Joo Weon Lim, Hyeyoung Kim

Research output: Contribution to journalArticle

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Abstract

Generation of excess quantities of reactive oxygen species (ROS) caused by mitochondrial dysfunction facilitates rapid growth of pancreatic cancer cells. Elevated ROS levels in cancer cells cause an anti-apoptotic effect by activating survival signaling pathways, such as NF-κB and its target gene expression. Lycopene, a carotenoid found in tomatoes and a potent antioxidant, displays a protective effect against pancreatic cancer. The present study was designed to determine if lycopene induces apoptosis of pancreatic cancer PANC-1 cells by decreasing intracellular and mitochondrial ROS levels, and consequently suppressing NF-κB activation and expression of NF-κB target genes including cIAP1, cIAP2, and survivin. The results show that the lycopene decreased intracellular and mitochondrial ROS levels, mitochondrial function (determined by the mitochondrial membrane potential and oxygen consumption rate), NF-κB activity, and expression of NF-κB-dependent survival genes in PANC-1 cells. Lycopene reduced cell viability with increases in active caspase-3 and the Bax to Bcl-2 ratio in PANC-1 cells. These findings suggest that supplementation of lycopene could potentially reduce the incidence of pancreatic cancer.

Original languageEnglish
Article number762
JournalNutrients
Volume11
Issue number4
DOIs
Publication statusPublished - 2019 Apr

Fingerprint

pancreatic neoplasms
lycopene
Pancreatic Neoplasms
reactive oxygen species
Reactive Oxygen Species
apoptosis
Apoptosis
Mitochondrial Membrane Potential
cells
caspase-3
Carotenoids
Lycopersicon esculentum
membrane potential
Oxygen Consumption
Caspase 3
oxygen consumption
Genes
cell viability
protective effect
Cell Survival

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

Cite this

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title = "Lycopene inhibits reactive oxygen species-mediated nf-kb signaling and induces apoptosis in pancreatic cancer cells",
abstract = "Generation of excess quantities of reactive oxygen species (ROS) caused by mitochondrial dysfunction facilitates rapid growth of pancreatic cancer cells. Elevated ROS levels in cancer cells cause an anti-apoptotic effect by activating survival signaling pathways, such as NF-κB and its target gene expression. Lycopene, a carotenoid found in tomatoes and a potent antioxidant, displays a protective effect against pancreatic cancer. The present study was designed to determine if lycopene induces apoptosis of pancreatic cancer PANC-1 cells by decreasing intracellular and mitochondrial ROS levels, and consequently suppressing NF-κB activation and expression of NF-κB target genes including cIAP1, cIAP2, and survivin. The results show that the lycopene decreased intracellular and mitochondrial ROS levels, mitochondrial function (determined by the mitochondrial membrane potential and oxygen consumption rate), NF-κB activity, and expression of NF-κB-dependent survival genes in PANC-1 cells. Lycopene reduced cell viability with increases in active caspase-3 and the Bax to Bcl-2 ratio in PANC-1 cells. These findings suggest that supplementation of lycopene could potentially reduce the incidence of pancreatic cancer.",
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Lycopene inhibits reactive oxygen species-mediated nf-kb signaling and induces apoptosis in pancreatic cancer cells. / Jeong, Yoonseon; Lim, Joo Weon; Kim, Hyeyoung.

In: Nutrients, Vol. 11, No. 4, 762, 04.2019.

Research output: Contribution to journalArticle

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AU - Lim, Joo Weon

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