Lymphangiogenesis in breast cancer correlates with matrix stiffness on shear-wave elastography

Yoon Jin Cha, Ji Hyun Youk, Baek Gil Kim, Woo Hee Jung, Namhoon Cho

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: To correlate tumor stiffness and lymphangiogenesis in breast cancer and to find its clinical implications. Materials and Methods: A total of 140 breast cancer patients were evaluated. Tumor stiffness was quantitatively measured by shear-wave elastography in preoperative ultrasound examination, calculated as mean elasticity value (kPa). Slides of resected breast cancer specimens were reviewed for most fibrotic area associated with tumor. D2-40 immunohistochemical staining was applied for fibrotic areas to detect the lymphatic spaces. Microlymphatic density, tumor stiffness, and clinicopathologic data were analyzed. Results: Higher elasticity value was associated with invasive size of tumor, microlymphatic density, histologic grade 3, absence of extensive intraductal component, presence of axillary lymph node metastasis, and Ki-67 labeling index (LI) in univariate regression analysis, and associated with Ki-67 LI and axillary lymph node metastasis in multivariate regression analysis. Microlymphatic density was associated histologic grade 3, mean elasticity value, and Ki-67 LI in univariate regression analysis. In multivariate regression analysis, microlymphatic density was correlated with mean elasticity value. Conclusion: In breast cancer, tumor stiffness correlates with lymphangiogenesis and poor prognostic factors.

Original languageEnglish
Pages (from-to)599-605
Number of pages7
JournalYonsei Medical Journal
Volume57
Issue number3
DOIs
Publication statusPublished - 2016 May 1

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Lymphangiogenesis
Elasticity Imaging Techniques
Elasticity
Breast Neoplasms
Regression Analysis
Neoplasms
Multivariate Analysis
Lymph Nodes
Neoplasm Metastasis
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Cha, Yoon Jin ; Youk, Ji Hyun ; Kim, Baek Gil ; Jung, Woo Hee ; Cho, Namhoon. / Lymphangiogenesis in breast cancer correlates with matrix stiffness on shear-wave elastography. In: Yonsei Medical Journal. 2016 ; Vol. 57, No. 3. pp. 599-605.
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Lymphangiogenesis in breast cancer correlates with matrix stiffness on shear-wave elastography. / Cha, Yoon Jin; Youk, Ji Hyun; Kim, Baek Gil; Jung, Woo Hee; Cho, Namhoon.

In: Yonsei Medical Journal, Vol. 57, No. 3, 01.05.2016, p. 599-605.

Research output: Contribution to journalArticle

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