Lymphatic vessel densities of lymph node-negative prostate adenocarcinoma in Korea

Hyun Soo Kim, Wooseok Sung, Sun Lee, Sung Goo Chang, Yong Koo Park

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Abstract

Although lymphatic vessel density (LVD) is associated with regional lymph node (LN) metastasis in prostate adenocarcinoma, no study is available that examines whether the LVD is correlated with prognostic factors other than LN metastasis in LN-negative prostate adenocarcinoma. The aim of our study was to analyze intratumoral (IT), peritumoral (PT), and nontumoral (NT) LVDs, and to determine if there is a correlation between the LVD and the clinicopathological parameters in the Korean LN-negative prostate adeocarcinoma patients. Lymphatics were detected by immunohistochemical staining using D2-40 antibody on 39 radical prostatectomy specimens. Mean LVDs of IT, PT, and NT compartments were 5.39±4.22, 10.71±4.61, and 2.04±1.34 per 200× field, respectively. The difference in LVD among the compartments was significant (P<0.001). The IT-LVD was significantly lower in patients with larger tumor volume (P=0.029) and higher preoperative prostate-specific antigen level (P=0.008). The PT-LVD showed no significant correlation with the clinicopathological parameters. Our results suggest that IT- and PT-LVDs may increase in LN-negative prostate adenocarcinoma as a result of lymphangiogenesis, but IT lymphatics may decrease due to mechanical compression and destruction caused by proliferating tumor cells. In addition, IT-LVD may be used as a prognostic factor in LN-negative prostate adenocarcinoma.

Original languageEnglish
Pages (from-to)249-254
Number of pages6
JournalPathology Research and Practice
Volume205
Issue number4
DOIs
Publication statusPublished - 2009 Apr 15

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All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Cell Biology

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