M. tuberculosis somatic antigen specific CD8+T cell responses in BCG-vaccinated subjects

Jang Eun Cho, Sangnae Cho, Kyung Wha Lee, Seung Kyu Park, Sungae Cho

Research output: Contribution to journalArticle

Abstract

Background: The immune responses mediated by CD8+T cells are known to be significant in controlling M. tuberculosis infections. In order to determine the role of cytotoxic CD8+T cells in the protective immune mechanism in latently infected subjects, this study examined whether or not the cytotoxic immune responses of CD8+T cells specific to the M. tuberculosis somatic antigens are induced in BCG vaccinated healthy subjects. Methods: Cytotoxicity and IFN-γ elispot assays were used to investigate the activities of CD8+T cells specific for the thyA30-38 peptide epitope in circulating peripheral blood mononuclear cells (PBMC) from BCG-vaccinated HLA-A*0201 and A*0206 subjects. Results: The results indicate the cytotoxic and IFN-γ immune responses of CD6+T cells specific for thyA30-38 were induced in BCG vaccinated healthy subjects. Conclusion: The cytotoxic and IFN-γ responses by CD8+T cells specific for the M. tuberculosis somatic antigens are induced in BCG-vaccinated subjects, and appear to be involved in the protective immune mechanism in latently infected people against a M. tuberculosis infection.

Original languageEnglish
Pages (from-to)272-278
Number of pages7
JournalTuberculosis and Respiratory Diseases
Volume59
Issue number3
DOIs
Publication statusPublished - 2005 Jan 1

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CD8 Antigens
Mycobacterium bovis
Tuberculosis
T-Lymphocytes
Healthy Volunteers
Antigens
Infection
Epitopes
Blood Cells
Peptides

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Cho, Jang Eun ; Cho, Sangnae ; Lee, Kyung Wha ; Park, Seung Kyu ; Cho, Sungae. / M. tuberculosis somatic antigen specific CD8+T cell responses in BCG-vaccinated subjects. In: Tuberculosis and Respiratory Diseases. 2005 ; Vol. 59, No. 3. pp. 272-278.
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M. tuberculosis somatic antigen specific CD8+T cell responses in BCG-vaccinated subjects. / Cho, Jang Eun; Cho, Sangnae; Lee, Kyung Wha; Park, Seung Kyu; Cho, Sungae.

In: Tuberculosis and Respiratory Diseases, Vol. 59, No. 3, 01.01.2005, p. 272-278.

Research output: Contribution to journalArticle

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