M. tuberculosis somatic antigen specific CD8+T cell responses in BCG-vaccinated subjects

Jang Eun Cho, Sang Nae Cho, Kyung Wha Lee, Seung Kyu Park, Sungae Cho

Research output: Contribution to journalArticle

Abstract

Background: The immune responses mediated by CD8+T cells are known to be significant in controlling M. tuberculosis infections. In order to determine the role of cytotoxic CD8+T cells in the protective immune mechanism in latently infected subjects, this study examined whether or not the cytotoxic immune responses of CD8+T cells specific to the M. tuberculosis somatic antigens are induced in BCG vaccinated healthy subjects. Methods: Cytotoxicity and IFN-γ elispot assays were used to investigate the activities of CD8+T cells specific for the thyA30-38 peptide epitope in circulating peripheral blood mononuclear cells (PBMC) from BCG-vaccinated HLA-A*0201 and A*0206 subjects. Results: The results indicate the cytotoxic and IFN-γ immune responses of CD6+T cells specific for thyA30-38 were induced in BCG vaccinated healthy subjects. Conclusion: The cytotoxic and IFN-γ responses by CD8+T cells specific for the M. tuberculosis somatic antigens are induced in BCG-vaccinated subjects, and appear to be involved in the protective immune mechanism in latently infected people against a M. tuberculosis infection.

Original languageEnglish
Pages (from-to)272-278
Number of pages7
JournalTuberculosis and Respiratory Diseases
Volume59
Issue number3
DOIs
Publication statusPublished - 2005 Sep

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Fingerprint Dive into the research topics of 'M. tuberculosis somatic antigen specific CD8+T cell responses in BCG-vaccinated subjects'. Together they form a unique fingerprint.

  • Cite this