Previous studies have shown that macelignan has anti-inflammatory and neuroprotective effects. Subsequently, in the current study, we demonstrate that oral administrations of macelignan reduce the hippocampal microglial activation induced by chronic infusions of lipopolysaccharide (LPS) into the fourth ventricle of Fisher-344 rat brains. A Morris water maze was used to evaluate the status of the hippocampal-dependent spatial learning in control rats with an artificial cerebrospinal fluid infusion, rats with chronic LPS infusions, and rats with chronic LPS infusions and oral administrations of macelignan. The rats with chronic LPS infusions showed spatial memory impairments relative to the control rats in the performance of the memory task. Daily administration of macelignan reduced the spatial memory impairments induced by the chronic LPS infusions. The results indicate that macelignan may possess therapeutic potential for the prevention of Alzheimer's disease.
Bibliographical noteFunding Information:
This research was supported by a grant (RTI04-03-07) from the regional technology innovation program of the Ministry of Commerce, Industry and Energy (MOCIE) to Amicogen Co. and Jung-Soo Han, and in part by a grant (R01-2006-000-11067-0(2006)) from the Basic Research Program of the Korea Science & Engineering Foundation (KOSEF) to Jung-Soo Han.
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