Macromolecular sensing of RNAs by exploiting conformational changes in supramolecular nanostructures

So Hee Han, Hee Won Kim, Woo Jin Jeong, Yong Beom Lim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Here, we report on a ratiometric fluorescence biosensor based on self-assembled peptide nanostructures (SPN), which can respond to conformational changes induced by RNA ligand binding. The design of the SPN biosensor was inspired by the conformational stabilization and multimerization behaviors of the HIV-1 Rev protein induced by cooperative protein-protein and protein-RNA interactions. Because conformation-sensitive SPN biosensors can orchestrate binding and signal transduction events, they can be developed as highly sophisticated and smart nanomaterials for biosensing.

Original languageEnglish
Pages (from-to)2642-2647
Number of pages6
JournalBiomacromolecules
Volume15
Issue number7
DOIs
Publication statusPublished - 2014 Jul 14

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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