Macular choroidal thickness changes in development, progression, and spontaneous resolution of epiretinal membrane

Eun Young Choi; Jongwook Han; Sung Chul Lee; Christopher Seungkyu Lee

doi:10.3928/23258160-20191009-05

Macular choroidal thickness changes in development, progression, and spontaneous resolution of epiretinal membrane

Eun Young Choi, Jongwook Han, Sung Chul Lee, Christopher Seungkyu Lee

Department of Ophthalmology

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

BACKGROUND AND OBJECTIVE: To evaluate the association between macular choroidal thickness and the development, progression, and resolution of epiretinal membrane (ERM). PATIENTS AND METHODS: The patients (n = 38) with unilateral ERM eyes with definitive changes on optical coherence tomography (OCT) and healthy fellow eyes were observed retrospectively. ERM eyes were divided into three groups: Development/new-onset group (n = 14), progression group (n = 13), and resolution group (n = 11). In each group, the average changes of macular choroidal thickness over time in ERM eyes were compared with those in the fellow eyes RESULTS: Choroidal thickness significantly decreased from 174.0 μm at baseline to 132.3 μm at event time (P = .001) in the development group, and from 140.0 μm ± 30.0 μm to 120.5 μm (P = .002) in the progression group. Conversely, a significant increase in choroidal thickness was observed in the resolution group (from 205.2 μm to 222.6 μm; P = .004). The fellow eyes showed no significant changes in choroidal thickness in all three groups. CONCLUSION: Choroidal thinning in newly developed or significantly progressed ERM eyes and choroidal thickening in spontaneously resolved ERM eyes suggest a clinical implication of choroidal changes in ERM.

Original language	English
Pages (from-to)	627-634
Number of pages	8
Journal	Ophthalmic Surgery Lasers and Imaging Retina
Volume	50
Issue number	10
DOIs	https://doi.org/10.3928/23258160-20191009-05
Publication status	Published - 2019

Bibliographical note

Funding Information:
Originally submitted September 12, 2018. Revision received January 10, 2019. Accepted for publication March 11, 2019. Paper presented at the 2017 Korean Retina Society Annual Meeting. Supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (NRF-2016R1D1A1A02937349). The funding organization had no role in the design or conduct of this research. The authors report no relevant financial disclosures. Address correspondence to Christopher Seungkyu Lee, MD, PhD, Department of Ophthalmology, Gangnam Severance Hospital, Yonsei University College of Medicine, 211, Eonjuro, Gangnam-gu, Seoul, Korea; email: sklee219@yuhs.ac. doi: 10.3928/23258160-20191009-05

Publisher Copyright:
© 2019 Slack Incorporated. All rights reserved.

All Science Journal Classification (ASJC) codes

Surgery
Ophthalmology

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10.3928/23258160-20191009-05

Cite this

@article{39ae76189dc54a4cba8c918dfbaf63b0,

title = "Macular choroidal thickness changes in development, progression, and spontaneous resolution of epiretinal membrane",

abstract = "BACKGROUND AND OBJECTIVE: To evaluate the association between macular choroidal thickness and the development, progression, and resolution of epiretinal membrane (ERM). PATIENTS AND METHODS: The patients (n = 38) with unilateral ERM eyes with definitive changes on optical coherence tomography (OCT) and healthy fellow eyes were observed retrospectively. ERM eyes were divided into three groups: Development/new-onset group (n = 14), progression group (n = 13), and resolution group (n = 11). In each group, the average changes of macular choroidal thickness over time in ERM eyes were compared with those in the fellow eyes RESULTS: Choroidal thickness significantly decreased from 174.0 μm at baseline to 132.3 μm at event time (P = .001) in the development group, and from 140.0 μm ± 30.0 μm to 120.5 μm (P = .002) in the progression group. Conversely, a significant increase in choroidal thickness was observed in the resolution group (from 205.2 μm to 222.6 μm; P = .004). The fellow eyes showed no significant changes in choroidal thickness in all three groups. CONCLUSION: Choroidal thinning in newly developed or significantly progressed ERM eyes and choroidal thickening in spontaneously resolved ERM eyes suggest a clinical implication of choroidal changes in ERM.",

author = "Choi, {Eun Young} and Jongwook Han and Lee, {Sung Chul} and Lee, {Christopher Seungkyu}",

note = "Funding Information: Originally submitted September 12, 2018. Revision received January 10, 2019. Accepted for publication March 11, 2019. Paper presented at the 2017 Korean Retina Society Annual Meeting. Supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (NRF-2016R1D1A1A02937349). The funding organization had no role in the design or conduct of this research. The authors report no relevant financial disclosures. Address correspondence to Christopher Seungkyu Lee, MD, PhD, Department of Ophthalmology, Gangnam Severance Hospital, Yonsei University College of Medicine, 211, Eonjuro, Gangnam-gu, Seoul, Korea; email: sklee219@yuhs.ac. doi: 10.3928/23258160-20191009-05 Publisher Copyright: {\textcopyright} 2019 Slack Incorporated. All rights reserved.",

year = "2019",

doi = "10.3928/23258160-20191009-05",

language = "English",

volume = "50",

pages = "627--634",

journal = "Ophthalmic Surgery Lasers and Imaging Retina",

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T1 - Macular choroidal thickness changes in development, progression, and spontaneous resolution of epiretinal membrane

AU - Choi, Eun Young

AU - Han, Jongwook

AU - Lee, Sung Chul

AU - Lee, Christopher Seungkyu

N1 - Funding Information: Originally submitted September 12, 2018. Revision received January 10, 2019. Accepted for publication March 11, 2019. Paper presented at the 2017 Korean Retina Society Annual Meeting. Supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (NRF-2016R1D1A1A02937349). The funding organization had no role in the design or conduct of this research. The authors report no relevant financial disclosures. Address correspondence to Christopher Seungkyu Lee, MD, PhD, Department of Ophthalmology, Gangnam Severance Hospital, Yonsei University College of Medicine, 211, Eonjuro, Gangnam-gu, Seoul, Korea; email: sklee219@yuhs.ac. doi: 10.3928/23258160-20191009-05 Publisher Copyright: © 2019 Slack Incorporated. All rights reserved.

PY - 2019

Y1 - 2019

N2 - BACKGROUND AND OBJECTIVE: To evaluate the association between macular choroidal thickness and the development, progression, and resolution of epiretinal membrane (ERM). PATIENTS AND METHODS: The patients (n = 38) with unilateral ERM eyes with definitive changes on optical coherence tomography (OCT) and healthy fellow eyes were observed retrospectively. ERM eyes were divided into three groups: Development/new-onset group (n = 14), progression group (n = 13), and resolution group (n = 11). In each group, the average changes of macular choroidal thickness over time in ERM eyes were compared with those in the fellow eyes RESULTS: Choroidal thickness significantly decreased from 174.0 μm at baseline to 132.3 μm at event time (P = .001) in the development group, and from 140.0 μm ± 30.0 μm to 120.5 μm (P = .002) in the progression group. Conversely, a significant increase in choroidal thickness was observed in the resolution group (from 205.2 μm to 222.6 μm; P = .004). The fellow eyes showed no significant changes in choroidal thickness in all three groups. CONCLUSION: Choroidal thinning in newly developed or significantly progressed ERM eyes and choroidal thickening in spontaneously resolved ERM eyes suggest a clinical implication of choroidal changes in ERM.

AB - BACKGROUND AND OBJECTIVE: To evaluate the association between macular choroidal thickness and the development, progression, and resolution of epiretinal membrane (ERM). PATIENTS AND METHODS: The patients (n = 38) with unilateral ERM eyes with definitive changes on optical coherence tomography (OCT) and healthy fellow eyes were observed retrospectively. ERM eyes were divided into three groups: Development/new-onset group (n = 14), progression group (n = 13), and resolution group (n = 11). In each group, the average changes of macular choroidal thickness over time in ERM eyes were compared with those in the fellow eyes RESULTS: Choroidal thickness significantly decreased from 174.0 μm at baseline to 132.3 μm at event time (P = .001) in the development group, and from 140.0 μm ± 30.0 μm to 120.5 μm (P = .002) in the progression group. Conversely, a significant increase in choroidal thickness was observed in the resolution group (from 205.2 μm to 222.6 μm; P = .004). The fellow eyes showed no significant changes in choroidal thickness in all three groups. CONCLUSION: Choroidal thinning in newly developed or significantly progressed ERM eyes and choroidal thickening in spontaneously resolved ERM eyes suggest a clinical implication of choroidal changes in ERM.

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JO - Ophthalmic Surgery Lasers and Imaging Retina

JF - Ophthalmic Surgery Lasers and Imaging Retina

IS - 10

ER -

Macular choroidal thickness changes in development, progression, and spontaneous resolution of epiretinal membrane

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