Macular thickness variations with sex, age, and axial length in healthy subjects

A spectral domain-optical coherence tomography study

Won Kyung Song, Sungchul Lee, Eun Suk Lee, chanyun kim, Sung Soo Kim

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

PURPOSE. To assess the relationship between macular retinal thickness and volume and age, sex, and refractive error/axial length with spectral domain-optical coherence tomography (SD-OCT). METHODS. One randomly selected eye of 198 consecutive ophthalmically normal subjects (104 men, 94 women) between July 2008 and January 2009, with corrected visual acuities better than 20/30 were included in this cross-sectional study. Complete ophthalmic examination, axial length measurement with a laser interferometer, and macular cube 512×128 scan by SD-OCT were performed. RESULTS. The mean age was 55.6±16.4 years (range, 17-83), average refractive error was -2.17±4.82 (range, -23.50-3.75), and average axial length was 24.73±1.98 mm (range, 21.52-32.51). The central subfield thickness, average inner macular thickness, and overall macular volume were significantly lower in the female subjects (partial correlation: P=0.009, P=0.027, and P= 0.042, respectively). As age increased, average inner macular thickness, average outer macular thickness, overall average macular thickness, and macular volume decreased significantly (partial correlation: P= 0.002, P= 0.002, P= 0.002, and P= 0.000, respectively). Refractive error had no significant influence in partial correlation analysis. Axial length correlated negatively with average outer macular thickness, overall average macular thickness, and macular volume (partial correlation: P= 0.006, P =0.044, and P=0.003, respectively). CONCLUSIONS. In normal subjects, SD-OCT showed that retinal thickness is related to age, sex, and axial length, with regional variations.

Original languageEnglish
Pages (from-to)3913-3918
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Volume51
Issue number8
DOIs
Publication statusPublished - 2010 Aug 1

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Refractive Errors
Optical Coherence Tomography
Healthy Volunteers
Eye Axial Length
Visual Acuity
Lasers
Cross-Sectional Studies

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

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title = "Macular thickness variations with sex, age, and axial length in healthy subjects: A spectral domain-optical coherence tomography study",
abstract = "PURPOSE. To assess the relationship between macular retinal thickness and volume and age, sex, and refractive error/axial length with spectral domain-optical coherence tomography (SD-OCT). METHODS. One randomly selected eye of 198 consecutive ophthalmically normal subjects (104 men, 94 women) between July 2008 and January 2009, with corrected visual acuities better than 20/30 were included in this cross-sectional study. Complete ophthalmic examination, axial length measurement with a laser interferometer, and macular cube 512×128 scan by SD-OCT were performed. RESULTS. The mean age was 55.6±16.4 years (range, 17-83), average refractive error was -2.17±4.82 (range, -23.50-3.75), and average axial length was 24.73±1.98 mm (range, 21.52-32.51). The central subfield thickness, average inner macular thickness, and overall macular volume were significantly lower in the female subjects (partial correlation: P=0.009, P=0.027, and P= 0.042, respectively). As age increased, average inner macular thickness, average outer macular thickness, overall average macular thickness, and macular volume decreased significantly (partial correlation: P= 0.002, P= 0.002, P= 0.002, and P= 0.000, respectively). Refractive error had no significant influence in partial correlation analysis. Axial length correlated negatively with average outer macular thickness, overall average macular thickness, and macular volume (partial correlation: P= 0.006, P =0.044, and P=0.003, respectively). CONCLUSIONS. In normal subjects, SD-OCT showed that retinal thickness is related to age, sex, and axial length, with regional variations.",
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Macular thickness variations with sex, age, and axial length in healthy subjects : A spectral domain-optical coherence tomography study. / Song, Won Kyung; Lee, Sungchul; Lee, Eun Suk; kim, chanyun; Kim, Sung Soo.

In: Investigative Ophthalmology and Visual Science, Vol. 51, No. 8, 01.08.2010, p. 3913-3918.

Research output: Contribution to journalArticle

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T1 - Macular thickness variations with sex, age, and axial length in healthy subjects

T2 - A spectral domain-optical coherence tomography study

AU - Song, Won Kyung

AU - Lee, Sungchul

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AU - Kim, Sung Soo

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N2 - PURPOSE. To assess the relationship between macular retinal thickness and volume and age, sex, and refractive error/axial length with spectral domain-optical coherence tomography (SD-OCT). METHODS. One randomly selected eye of 198 consecutive ophthalmically normal subjects (104 men, 94 women) between July 2008 and January 2009, with corrected visual acuities better than 20/30 were included in this cross-sectional study. Complete ophthalmic examination, axial length measurement with a laser interferometer, and macular cube 512×128 scan by SD-OCT were performed. RESULTS. The mean age was 55.6±16.4 years (range, 17-83), average refractive error was -2.17±4.82 (range, -23.50-3.75), and average axial length was 24.73±1.98 mm (range, 21.52-32.51). The central subfield thickness, average inner macular thickness, and overall macular volume were significantly lower in the female subjects (partial correlation: P=0.009, P=0.027, and P= 0.042, respectively). As age increased, average inner macular thickness, average outer macular thickness, overall average macular thickness, and macular volume decreased significantly (partial correlation: P= 0.002, P= 0.002, P= 0.002, and P= 0.000, respectively). Refractive error had no significant influence in partial correlation analysis. Axial length correlated negatively with average outer macular thickness, overall average macular thickness, and macular volume (partial correlation: P= 0.006, P =0.044, and P=0.003, respectively). CONCLUSIONS. In normal subjects, SD-OCT showed that retinal thickness is related to age, sex, and axial length, with regional variations.

AB - PURPOSE. To assess the relationship between macular retinal thickness and volume and age, sex, and refractive error/axial length with spectral domain-optical coherence tomography (SD-OCT). METHODS. One randomly selected eye of 198 consecutive ophthalmically normal subjects (104 men, 94 women) between July 2008 and January 2009, with corrected visual acuities better than 20/30 were included in this cross-sectional study. Complete ophthalmic examination, axial length measurement with a laser interferometer, and macular cube 512×128 scan by SD-OCT were performed. RESULTS. The mean age was 55.6±16.4 years (range, 17-83), average refractive error was -2.17±4.82 (range, -23.50-3.75), and average axial length was 24.73±1.98 mm (range, 21.52-32.51). The central subfield thickness, average inner macular thickness, and overall macular volume were significantly lower in the female subjects (partial correlation: P=0.009, P=0.027, and P= 0.042, respectively). As age increased, average inner macular thickness, average outer macular thickness, overall average macular thickness, and macular volume decreased significantly (partial correlation: P= 0.002, P= 0.002, P= 0.002, and P= 0.000, respectively). Refractive error had no significant influence in partial correlation analysis. Axial length correlated negatively with average outer macular thickness, overall average macular thickness, and macular volume (partial correlation: P= 0.006, P =0.044, and P=0.003, respectively). CONCLUSIONS. In normal subjects, SD-OCT showed that retinal thickness is related to age, sex, and axial length, with regional variations.

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