Abstract
The bullfrog sacculus contains mechanically sensitive hair cells whose stereociliary bundles oscillate spontaneously when decoupled from the overlying membrane. Steady-state offsets on the resting position of a hair bundle can suppress or modulate this native motility. To probe the dynamics of spontaneous oscillation in the proximity of the critical point, we describe here a method for mechanical actuation that avoids loading the bundles or contributing to the viscous drag. Magnetite beads were attached to the tips of the stereocilia, and a magnetic probe was used to impose deflections. This technique allowed us to observe the transition from multi-mode to single-mode state in freely oscillating bundles, as well as the crossover from the oscillatory to the quiescent state.
| Original language | English |
|---|---|
| Article number | 193701 |
| Journal | Applied Physics Letters |
| Volume | 99 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - 2011 Nov 7 |
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All Science Journal Classification (ASJC) codes
- Physics and Astronomy (miscellaneous)
Cite this
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Magnetic actuation of hair cells. / Rowland, David; Roongthumskul, Yuttana; Lee, Jae-Hyun; Cheon, Jinwoo; Bozovic, Dolores.
In: Applied Physics Letters, Vol. 99, No. 19, 193701, 07.11.2011.Research output: Contribution to journal › Article
TY - JOUR
T1 - Magnetic actuation of hair cells
AU - Rowland, David
AU - Roongthumskul, Yuttana
AU - Lee, Jae-Hyun
AU - Cheon, Jinwoo
AU - Bozovic, Dolores
PY - 2011/11/7
Y1 - 2011/11/7
N2 - The bullfrog sacculus contains mechanically sensitive hair cells whose stereociliary bundles oscillate spontaneously when decoupled from the overlying membrane. Steady-state offsets on the resting position of a hair bundle can suppress or modulate this native motility. To probe the dynamics of spontaneous oscillation in the proximity of the critical point, we describe here a method for mechanical actuation that avoids loading the bundles or contributing to the viscous drag. Magnetite beads were attached to the tips of the stereocilia, and a magnetic probe was used to impose deflections. This technique allowed us to observe the transition from multi-mode to single-mode state in freely oscillating bundles, as well as the crossover from the oscillatory to the quiescent state.
AB - The bullfrog sacculus contains mechanically sensitive hair cells whose stereociliary bundles oscillate spontaneously when decoupled from the overlying membrane. Steady-state offsets on the resting position of a hair bundle can suppress or modulate this native motility. To probe the dynamics of spontaneous oscillation in the proximity of the critical point, we describe here a method for mechanical actuation that avoids loading the bundles or contributing to the viscous drag. Magnetite beads were attached to the tips of the stereocilia, and a magnetic probe was used to impose deflections. This technique allowed us to observe the transition from multi-mode to single-mode state in freely oscillating bundles, as well as the crossover from the oscillatory to the quiescent state.
UR - http://www.scopus.com/inward/record.url?scp=81155125064&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=81155125064&partnerID=8YFLogxK
U2 - 10.1063/1.3659299
DO - 10.1063/1.3659299
M3 - Article
VL - 99
JO - Applied Physics Letters
JF - Applied Physics Letters
SN - 0003-6951
IS - 19
M1 - 193701
ER -