Magnetic bead actuation of saccular hair cells

David Rowland, Damien Ramunno-Johnson, Jae Hyun Lee, Jinwoo Cheon, Dolores Bozovic

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

When decoupled from the overlying membrane, hair bundles of the amphibian sacculus exhibit spontaneous oscillation. To explore the dynamics of this innate motility without an imposed external load, we recorded their oscillations with a high-speed CMOS camera, and applied mechanical manipulation that minimally alters the geometry of an individual hair bundle. We present a technique that utilizes micron-sized magnetic particles to actuate the stereociliary bundle with a magnetized probe. Quasi-steady-state displacements were imposed on freely oscillating bundles. Our data indicate that deflection of the bundle affects both the frequency and the amplitude of the oscillations, with a crossing of the bifurcation that is dependent on the direction and speed of the applied offset.

Original languageEnglish
Title of host publicationWhat Fire is in Mine Ears
Subtitle of host publicationProgress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop
Pages128-132
Number of pages5
DOIs
Publication statusPublished - 2011 Dec 12
Event11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics - Williamstown, MA, United States
Duration: 2011 Jul 162011 Jul 22

Publication series

NameAIP Conference Proceedings
Volume1403
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics
CountryUnited States
CityWilliamstown, MA
Period11/7/1611/7/22

Fingerprint

hair
actuation
beads
bundles
oscillations
quasi-steady states
locomotion
deflection
manipulators
CMOS
cameras
high speed
membranes
probes
geometry

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

Cite this

Rowland, D., Ramunno-Johnson, D., Lee, J. H., Cheon, J., & Bozovic, D. (2011). Magnetic bead actuation of saccular hair cells. In What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop (pp. 128-132). (AIP Conference Proceedings; Vol. 1403). https://doi.org/10.1063/1.3658072
Rowland, David ; Ramunno-Johnson, Damien ; Lee, Jae Hyun ; Cheon, Jinwoo ; Bozovic, Dolores. / Magnetic bead actuation of saccular hair cells. What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. 2011. pp. 128-132 (AIP Conference Proceedings).
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Rowland, D, Ramunno-Johnson, D, Lee, JH, Cheon, J & Bozovic, D 2011, Magnetic bead actuation of saccular hair cells. in What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. AIP Conference Proceedings, vol. 1403, pp. 128-132, 11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics, Williamstown, MA, United States, 11/7/16. https://doi.org/10.1063/1.3658072

Magnetic bead actuation of saccular hair cells. / Rowland, David; Ramunno-Johnson, Damien; Lee, Jae Hyun; Cheon, Jinwoo; Bozovic, Dolores.

What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. 2011. p. 128-132 (AIP Conference Proceedings; Vol. 1403).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Rowland D, Ramunno-Johnson D, Lee JH, Cheon J, Bozovic D. Magnetic bead actuation of saccular hair cells. In What Fire is in Mine Ears: Progress in Auditory Biomechanics - Proceedings of the 11th International Mechanics of Hearing Workshop. 2011. p. 128-132. (AIP Conference Proceedings). https://doi.org/10.1063/1.3658072