Magnetic Control of Axon Navigation in Reprogrammed Neurons

Yoonhee Jin, Jung Uk Lee, Eunna Chung, Kisuk Yang, Jin Kim, Ji Wook Kim, Jong Seung Lee, Ann Na Cho, Taekyu Oh, Jae Hyun Lee, Seung Woo Cho, Jinwoo Cheon

Research output: Contribution to journalArticle

Abstract

While neural cell transplantation represents a promising therapy for neurodegenerative diseases, the formation of functional networks of transplanted cells with host neurons constitutes one of the challenging steps. Here, we introduce a magnetic guidance methodology that controls neurite growth signaling via magnetic nanoparticles (MNPs) conjugated with antibodies targeting the deleted in colorectal cancer (DCC) receptor (DCC-MNPs). Activation of the DCC receptors by clusterization and subsequent axonal growth of the induced neuronal (iN) cells was performed in a spatially controlled manner. In addition to the directionality of the magnetically controlled axon projection, axonal growth of the iN cells assisted the formation of functional connections with pre-existing primary neurons. Our results suggest magnetic guidance as a strategy for improving neuronal connectivity by spatially guiding the axonal projections of transplanted neural cells for synaptic interactions with the host tissue.

Original languageEnglish
Pages (from-to)6517-6523
Number of pages7
JournalNano letters
Volume19
Issue number9
DOIs
Publication statusPublished - 2019 Sep 11

Fingerprint

magnetic control
axons
navigation
neurons
Neurons
Navigation
cells
Neurodegenerative diseases
Nanoparticles
cancer
Antibodies
projection
transplantation
Chemical activation
nanoparticles
Tissue
antibodies
therapy
Axons
activation

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

Cite this

Jin, Y., Lee, J. U., Chung, E., Yang, K., Kim, J., Kim, J. W., ... Cheon, J. (2019). Magnetic Control of Axon Navigation in Reprogrammed Neurons. Nano letters, 19(9), 6517-6523. https://doi.org/10.1021/acs.nanolett.9b02756
Jin, Yoonhee ; Lee, Jung Uk ; Chung, Eunna ; Yang, Kisuk ; Kim, Jin ; Kim, Ji Wook ; Lee, Jong Seung ; Cho, Ann Na ; Oh, Taekyu ; Lee, Jae Hyun ; Cho, Seung Woo ; Cheon, Jinwoo. / Magnetic Control of Axon Navigation in Reprogrammed Neurons. In: Nano letters. 2019 ; Vol. 19, No. 9. pp. 6517-6523.
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Jin, Y, Lee, JU, Chung, E, Yang, K, Kim, J, Kim, JW, Lee, JS, Cho, AN, Oh, T, Lee, JH, Cho, SW & Cheon, J 2019, 'Magnetic Control of Axon Navigation in Reprogrammed Neurons', Nano letters, vol. 19, no. 9, pp. 6517-6523. https://doi.org/10.1021/acs.nanolett.9b02756

Magnetic Control of Axon Navigation in Reprogrammed Neurons. / Jin, Yoonhee; Lee, Jung Uk; Chung, Eunna; Yang, Kisuk; Kim, Jin; Kim, Ji Wook; Lee, Jong Seung; Cho, Ann Na; Oh, Taekyu; Lee, Jae Hyun; Cho, Seung Woo; Cheon, Jinwoo.

In: Nano letters, Vol. 19, No. 9, 11.09.2019, p. 6517-6523.

Research output: Contribution to journalArticle

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AU - Jin, Yoonhee

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AU - Kim, Ji Wook

AU - Lee, Jong Seung

AU - Cho, Ann Na

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AU - Lee, Jae Hyun

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AU - Cheon, Jinwoo

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Jin Y, Lee JU, Chung E, Yang K, Kim J, Kim JW et al. Magnetic Control of Axon Navigation in Reprogrammed Neurons. Nano letters. 2019 Sep 11;19(9):6517-6523. https://doi.org/10.1021/acs.nanolett.9b02756