Magnetic nanoclusters engineered by polymer-controlled self-assembly for the accurate diagnosis of atherosclerotic plaques via magnetic resonance imaging

Myeong Hoon Kim, Bongjune Kim, Eun Kyung Lim, Yuna Choi, Jihye Choi, Eunjung Kim, Eunji Jang, Hyo Seon Park, Jinsuck Suh, yongmin Huh, Seungjoo Haam

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Oleyl dextran-coated magnetic nanoclusters (ODMCs) are fabricated for the accurate detection of macrophage-rich atherosclerotic plaques using magnetic resonance (MR) imaging. Dextran is introduced to the cluster surface of magnetic nanocrystals (MNCs) through self-assembly using amphiphilic oleic acid-conjugated dextran (ODex) to provide not only hydrophilicity but also a high affinity to macrophages. Enhanced magnetism of the ODMCs is engineered by optimizing the degree of substitution (DS) of the oleyl group in ODex and the concentration of ODex used for the synthesis of ODMC. Consequently, ODMCs exhibit significantly increased T2 relaxivity and excellent macrophage-targeting ability without cytotoxicity, in vitro. Moreover, in vivo T2-weighted MR imaging after intravenous injection of ODMCs into a rat artery balloon injury model demonstrates considerable MR contrast strength efficacy in the plaques of the injured carotid artery. These novel ODMCs may offer a highly efficient MR imaging nanoprobes for the selective diagnosis of atherosclerosis. Oleyl dextran (ODex) coated magnetic nanocluster (ODMC) is developed and engineered by polymer-controlled self-assembly to be used as efficient MR imaging nanoprobe of atherosclerosis. T2 relaxivity of ODMCs is highly enhanced by controlling the condition of ODex including the degree of substitution of the oleyl group and the concentration used for the synthesis of ODMCs.

Original languageEnglish
Pages (from-to)943-952
Number of pages10
JournalMacromolecular Bioscience
Volume14
Issue number7
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Dextran
Nanoclusters
Atherosclerotic Plaques
Magnetic resonance
Dextrans
Self assembly
Polymers
Magnetic Resonance Imaging
Imaging techniques
Macrophages
Nanoprobes
Atherosclerosis
Substitution reactions
Oleic acid
Carotid Stenosis
Balloons
Hydrophilicity
Magnetism
Oleic Acid
Cytotoxicity

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

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title = "Magnetic nanoclusters engineered by polymer-controlled self-assembly for the accurate diagnosis of atherosclerotic plaques via magnetic resonance imaging",
abstract = "Oleyl dextran-coated magnetic nanoclusters (ODMCs) are fabricated for the accurate detection of macrophage-rich atherosclerotic plaques using magnetic resonance (MR) imaging. Dextran is introduced to the cluster surface of magnetic nanocrystals (MNCs) through self-assembly using amphiphilic oleic acid-conjugated dextran (ODex) to provide not only hydrophilicity but also a high affinity to macrophages. Enhanced magnetism of the ODMCs is engineered by optimizing the degree of substitution (DS) of the oleyl group in ODex and the concentration of ODex used for the synthesis of ODMC. Consequently, ODMCs exhibit significantly increased T2 relaxivity and excellent macrophage-targeting ability without cytotoxicity, in vitro. Moreover, in vivo T2-weighted MR imaging after intravenous injection of ODMCs into a rat artery balloon injury model demonstrates considerable MR contrast strength efficacy in the plaques of the injured carotid artery. These novel ODMCs may offer a highly efficient MR imaging nanoprobes for the selective diagnosis of atherosclerosis. Oleyl dextran (ODex) coated magnetic nanocluster (ODMC) is developed and engineered by polymer-controlled self-assembly to be used as efficient MR imaging nanoprobe of atherosclerosis. T2 relaxivity of ODMCs is highly enhanced by controlling the condition of ODex including the degree of substitution of the oleyl group and the concentration used for the synthesis of ODMCs.",
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Magnetic nanoclusters engineered by polymer-controlled self-assembly for the accurate diagnosis of atherosclerotic plaques via magnetic resonance imaging. / Kim, Myeong Hoon; Kim, Bongjune; Lim, Eun Kyung; Choi, Yuna; Choi, Jihye; Kim, Eunjung; Jang, Eunji; Park, Hyo Seon; Suh, Jinsuck; Huh, yongmin; Haam, Seungjoo.

In: Macromolecular Bioscience, Vol. 14, No. 7, 01.01.2014, p. 943-952.

Research output: Contribution to journalArticle

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AU - Kim, Myeong Hoon

AU - Kim, Bongjune

AU - Lim, Eun Kyung

AU - Choi, Yuna

AU - Choi, Jihye

AU - Kim, Eunjung

AU - Jang, Eunji

AU - Park, Hyo Seon

AU - Suh, Jinsuck

AU - Huh, yongmin

AU - Haam, Seungjoo

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N2 - Oleyl dextran-coated magnetic nanoclusters (ODMCs) are fabricated for the accurate detection of macrophage-rich atherosclerotic plaques using magnetic resonance (MR) imaging. Dextran is introduced to the cluster surface of magnetic nanocrystals (MNCs) through self-assembly using amphiphilic oleic acid-conjugated dextran (ODex) to provide not only hydrophilicity but also a high affinity to macrophages. Enhanced magnetism of the ODMCs is engineered by optimizing the degree of substitution (DS) of the oleyl group in ODex and the concentration of ODex used for the synthesis of ODMC. Consequently, ODMCs exhibit significantly increased T2 relaxivity and excellent macrophage-targeting ability without cytotoxicity, in vitro. Moreover, in vivo T2-weighted MR imaging after intravenous injection of ODMCs into a rat artery balloon injury model demonstrates considerable MR contrast strength efficacy in the plaques of the injured carotid artery. These novel ODMCs may offer a highly efficient MR imaging nanoprobes for the selective diagnosis of atherosclerosis. Oleyl dextran (ODex) coated magnetic nanocluster (ODMC) is developed and engineered by polymer-controlled self-assembly to be used as efficient MR imaging nanoprobe of atherosclerosis. T2 relaxivity of ODMCs is highly enhanced by controlling the condition of ODex including the degree of substitution of the oleyl group and the concentration used for the synthesis of ODMCs.

AB - Oleyl dextran-coated magnetic nanoclusters (ODMCs) are fabricated for the accurate detection of macrophage-rich atherosclerotic plaques using magnetic resonance (MR) imaging. Dextran is introduced to the cluster surface of magnetic nanocrystals (MNCs) through self-assembly using amphiphilic oleic acid-conjugated dextran (ODex) to provide not only hydrophilicity but also a high affinity to macrophages. Enhanced magnetism of the ODMCs is engineered by optimizing the degree of substitution (DS) of the oleyl group in ODex and the concentration of ODex used for the synthesis of ODMC. Consequently, ODMCs exhibit significantly increased T2 relaxivity and excellent macrophage-targeting ability without cytotoxicity, in vitro. Moreover, in vivo T2-weighted MR imaging after intravenous injection of ODMCs into a rat artery balloon injury model demonstrates considerable MR contrast strength efficacy in the plaques of the injured carotid artery. These novel ODMCs may offer a highly efficient MR imaging nanoprobes for the selective diagnosis of atherosclerosis. Oleyl dextran (ODex) coated magnetic nanocluster (ODMC) is developed and engineered by polymer-controlled self-assembly to be used as efficient MR imaging nanoprobe of atherosclerosis. T2 relaxivity of ODMCs is highly enhanced by controlling the condition of ODex including the degree of substitution of the oleyl group and the concentration used for the synthesis of ODMCs.

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