Magnetic nanovector enabling miRNA-34a delivery for CD44 suppression with concurrent MR imaging

Hwunjae Lee; Hyun Ouk Kim; Hye Young Son; Sang Bock Lee; Eunji Jang; Byunghoon Kang; Seungjoo Haam; Eun Kyung Lim; Yong Min Huh

doi:10.1166/jnn.2016.13797

Magnetic nanovector enabling miRNA-34a delivery for CD44 suppression with concurrent MR imaging

Hwunjae Lee, Hyun Ouk Kim, Hye Young Son, Sang Bock Lee, Eunji Jang, Byunghoon Kang, Seungjoo Haam, Eun Kyung Lim, Yong Min Huh

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

We report the development of a microRNA (miRNA)-based theragnostic system that can facilitate simple therapeutic miRNA-34a delivery and visualization by high-resolution magnetic resonance (MR) imaging. Magnetic nanovectors were formed by directly attaching miRNA-34a to the surface of magnetic nanoparticles (MNPs), modified nitrosonium tetrafluoroborate (NOBF₄) and subsequently introduced polyethylene glycol (PEG) molecules for high stability in an aqueous phase. The miRNA-34a-conjugated magnetic nanovectors showed therapeutic effects, inhibiting cellular migration and invasion through CD44 gene suppression; they also exhibited a strong MR signal. These results demonstrate that magnetic nanovectors have potential as theragnostic nanosystems for miRNA-based cancer therapy.

Original language	English
Pages (from-to)	12939-12946
Number of pages	8
Journal	Journal of Nanoscience and Nanotechnology
Volume	16
Issue number	12
DOIs	https://doi.org/10.1166/jnn.2016.13797
Publication status	Published - 2016 Dec 1

Bibliographical note

Funding Information:
This work was supported by grants from the National Research Foundation of Korea (NRF) funded by the Korean government (MEST) (NRF-2015M3A9D7029834 and NRF-2006-2004649) and the KRIBB Research Initiative Program, Republic of Korea.

Publisher Copyright:
Copyright © 2016 American Scientific Publishers All rights reserved.

All Science Journal Classification (ASJC) codes

Bioengineering
Chemistry(all)
Biomedical Engineering
Materials Science(all)
Condensed Matter Physics

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10.1166/jnn.2016.13797

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abstract = "We report the development of a microRNA (miRNA)-based theragnostic system that can facilitate simple therapeutic miRNA-34a delivery and visualization by high-resolution magnetic resonance (MR) imaging. Magnetic nanovectors were formed by directly attaching miRNA-34a to the surface of magnetic nanoparticles (MNPs), modified nitrosonium tetrafluoroborate (NOBF4) and subsequently introduced polyethylene glycol (PEG) molecules for high stability in an aqueous phase. The miRNA-34a-conjugated magnetic nanovectors showed therapeutic effects, inhibiting cellular migration and invasion through CD44 gene suppression; they also exhibited a strong MR signal. These results demonstrate that magnetic nanovectors have potential as theragnostic nanosystems for miRNA-based cancer therapy.",

author = "Hwunjae Lee and Kim, {Hyun Ouk} and Son, {Hye Young} and Lee, {Sang Bock} and Eunji Jang and Byunghoon Kang and Seungjoo Haam and Lim, {Eun Kyung} and Huh, {Yong Min}",

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doi = "10.1166/jnn.2016.13797",

language = "English",

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AU - Lee, Hwunjae

AU - Kim, Hyun Ouk

AU - Son, Hye Young

AU - Lee, Sang Bock

AU - Jang, Eunji

AU - Kang, Byunghoon

AU - Haam, Seungjoo

AU - Lim, Eun Kyung

AU - Huh, Yong Min

N1 - Funding Information: This work was supported by grants from the National Research Foundation of Korea (NRF) funded by the Korean government (MEST) (NRF-2015M3A9D7029834 and NRF-2006-2004649) and the KRIBB Research Initiative Program, Republic of Korea. Publisher Copyright: Copyright © 2016 American Scientific Publishers All rights reserved.

PY - 2016/12/1

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N2 - We report the development of a microRNA (miRNA)-based theragnostic system that can facilitate simple therapeutic miRNA-34a delivery and visualization by high-resolution magnetic resonance (MR) imaging. Magnetic nanovectors were formed by directly attaching miRNA-34a to the surface of magnetic nanoparticles (MNPs), modified nitrosonium tetrafluoroborate (NOBF4) and subsequently introduced polyethylene glycol (PEG) molecules for high stability in an aqueous phase. The miRNA-34a-conjugated magnetic nanovectors showed therapeutic effects, inhibiting cellular migration and invasion through CD44 gene suppression; they also exhibited a strong MR signal. These results demonstrate that magnetic nanovectors have potential as theragnostic nanosystems for miRNA-based cancer therapy.

AB - We report the development of a microRNA (miRNA)-based theragnostic system that can facilitate simple therapeutic miRNA-34a delivery and visualization by high-resolution magnetic resonance (MR) imaging. Magnetic nanovectors were formed by directly attaching miRNA-34a to the surface of magnetic nanoparticles (MNPs), modified nitrosonium tetrafluoroborate (NOBF4) and subsequently introduced polyethylene glycol (PEG) molecules for high stability in an aqueous phase. The miRNA-34a-conjugated magnetic nanovectors showed therapeutic effects, inhibiting cellular migration and invasion through CD44 gene suppression; they also exhibited a strong MR signal. These results demonstrate that magnetic nanovectors have potential as theragnostic nanosystems for miRNA-based cancer therapy.

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Magnetic nanovector enabling miRNA-34a delivery for CD44 suppression with concurrent MR imaging

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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