We report the development of a microRNA (miRNA)-based theragnostic system that can facilitate simple therapeutic miRNA-34a delivery and visualization by high-resolution magnetic resonance (MR) imaging. Magnetic nanovectors were formed by directly attaching miRNA-34a to the surface of magnetic nanoparticles (MNPs), modified nitrosonium tetrafluoroborate (NOBF4) and subsequently introduced polyethylene glycol (PEG) molecules for high stability in an aqueous phase. The miRNA-34a-conjugated magnetic nanovectors showed therapeutic effects, inhibiting cellular migration and invasion through CD44 gene suppression; they also exhibited a strong MR signal. These results demonstrate that magnetic nanovectors have potential as theragnostic nanosystems for miRNA-based cancer therapy.
Bibliographical noteFunding Information:
This work was supported by grants from the National Research Foundation of Korea (NRF) funded by the Korean government (MEST) (NRF-2015M3A9D7029834 and NRF-2006-2004649) and the KRIBB Research Initiative Program, Republic of Korea.
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All Science Journal Classification (ASJC) codes
- Biomedical Engineering
- Materials Science(all)
- Condensed Matter Physics