Abstract
We report the development of a microRNA (miRNA)-based theragnostic system that can facilitate simple therapeutic miRNA-34a delivery and visualization by high-resolution magnetic resonance (MR) imaging. Magnetic nanovectors were formed by directly attaching miRNA-34a to the surface of magnetic nanoparticles (MNPs), modified nitrosonium tetrafluoroborate (NOBF4) and subsequently introduced polyethylene glycol (PEG) molecules for high stability in an aqueous phase. The miRNA-34a-conjugated magnetic nanovectors showed therapeutic effects, inhibiting cellular migration and invasion through CD44 gene suppression; they also exhibited a strong MR signal. These results demonstrate that magnetic nanovectors have potential as theragnostic nanosystems for miRNA-based cancer therapy.
Original language | English |
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Pages (from-to) | 12939-12946 |
Number of pages | 8 |
Journal | Journal of Nanoscience and Nanotechnology |
Volume | 16 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2016 Dec 1 |
Bibliographical note
Funding Information:This work was supported by grants from the National Research Foundation of Korea (NRF) funded by the Korean government (MEST) (NRF-2015M3A9D7029834 and NRF-2006-2004649) and the KRIBB Research Initiative Program, Republic of Korea.
Publisher Copyright:
Copyright © 2016 American Scientific Publishers All rights reserved.
All Science Journal Classification (ASJC) codes
- Bioengineering
- Chemistry(all)
- Biomedical Engineering
- Materials Science(all)
- Condensed Matter Physics