Magnetic nanovector enabling miRNA-34a delivery for CD44 suppression with concurrent MR imaging

Hwunjae Lee, Hyun Ouk Kim, Hye Young Son, Sang Bock Lee, Eunji Jang, Byunghoon Kang, Seungjoo Haam, Eun Kyung Lim, Yong Min Huh

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

We report the development of a microRNA (miRNA)-based theragnostic system that can facilitate simple therapeutic miRNA-34a delivery and visualization by high-resolution magnetic resonance (MR) imaging. Magnetic nanovectors were formed by directly attaching miRNA-34a to the surface of magnetic nanoparticles (MNPs), modified nitrosonium tetrafluoroborate (NOBF4) and subsequently introduced polyethylene glycol (PEG) molecules for high stability in an aqueous phase. The miRNA-34a-conjugated magnetic nanovectors showed therapeutic effects, inhibiting cellular migration and invasion through CD44 gene suppression; they also exhibited a strong MR signal. These results demonstrate that magnetic nanovectors have potential as theragnostic nanosystems for miRNA-based cancer therapy.

Original languageEnglish
Pages (from-to)12939-12946
Number of pages8
JournalJournal of Nanoscience and Nanotechnology
Volume16
Issue number12
DOIs
Publication statusPublished - 2016 Dec 1

Bibliographical note

Funding Information:
This work was supported by grants from the National Research Foundation of Korea (NRF) funded by the Korean government (MEST) (NRF-2015M3A9D7029834 and NRF-2006-2004649) and the KRIBB Research Initiative Program, Republic of Korea.

Publisher Copyright:
Copyright © 2016 American Scientific Publishers All rights reserved.

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics

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