Magnetic PECA nanoparticles as drug carriers for targeted delivery: Synthesis and release characteristics

J. Yang, H. Lee, W. Hyung, S. B. Park, S. Haam

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Magnetic poly(ethyl-2-cyanoacrylate) (PECA) nanoparticles containing anti-cancer drugs (Cisplatin and Gemcitabine) were prepared by inter-facial polymerization. The spherical nanoparticles (d=250±15nm) with smooth surfaces and moderately uniform size distributions were obtained. The amount of magnetite encapsulated inside the polymer matrix was increased up to 14.26% (w/w) by controlling the initial weight ratio of monomer/magnetite. It was found that the amount of Cisplatin encapsulated in the magnetic nanoparticle is much higher than that of Gemcitabine because Cisplatin (hydrophobic) is highly soluble in the oil phase and encapsulated easier inside nanoparticles compared to Gemcitabine (hydrophilic). The presence of magnetite and its super-paramagnetic characteristic were confirmed by FTIR spectra and VSM. In-vitro experiments of drug release and magnetic mobility under external magnetic field demonstrated that magnetic poly(ethyl-2-cyanoacrylate) (PECA) nanoparticles can be a highly versatile magnetic drug carrier with sustained release behaviour and sufficient magnetic susceptibility.

Original languageEnglish
Pages (from-to)203-212
Number of pages10
JournalJournal of Microencapsulation
Volume23
Issue number2
DOIs
Publication statusPublished - 2006 Mar 1

Fingerprint

gemcitabine
Drug Carriers
Nanoparticles
Ferrosoferric Oxide
delivery
drugs
Magnetite
nanoparticles
magnetite
Cisplatin
synthesis
Fourier Transform Infrared Spectroscopy
Magnetic Fields
Polymer matrix
Magnetic susceptibility
Polymerization
Pharmaceutical Preparations
Polymers
Oils
polymerization

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Pharmaceutical Science
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Colloid and Surface Chemistry

Cite this

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abstract = "Magnetic poly(ethyl-2-cyanoacrylate) (PECA) nanoparticles containing anti-cancer drugs (Cisplatin and Gemcitabine) were prepared by inter-facial polymerization. The spherical nanoparticles (d=250±15nm) with smooth surfaces and moderately uniform size distributions were obtained. The amount of magnetite encapsulated inside the polymer matrix was increased up to 14.26{\%} (w/w) by controlling the initial weight ratio of monomer/magnetite. It was found that the amount of Cisplatin encapsulated in the magnetic nanoparticle is much higher than that of Gemcitabine because Cisplatin (hydrophobic) is highly soluble in the oil phase and encapsulated easier inside nanoparticles compared to Gemcitabine (hydrophilic). The presence of magnetite and its super-paramagnetic characteristic were confirmed by FTIR spectra and VSM. In-vitro experiments of drug release and magnetic mobility under external magnetic field demonstrated that magnetic poly(ethyl-2-cyanoacrylate) (PECA) nanoparticles can be a highly versatile magnetic drug carrier with sustained release behaviour and sufficient magnetic susceptibility.",
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Magnetic PECA nanoparticles as drug carriers for targeted delivery : Synthesis and release characteristics. / Yang, J.; Lee, H.; Hyung, W.; Park, S. B.; Haam, S.

In: Journal of Microencapsulation, Vol. 23, No. 2, 01.03.2006, p. 203-212.

Research output: Contribution to journalArticle

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T1 - Magnetic PECA nanoparticles as drug carriers for targeted delivery

T2 - Synthesis and release characteristics

AU - Yang, J.

AU - Lee, H.

AU - Hyung, W.

AU - Park, S. B.

AU - Haam, S.

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