Magnetic poly ε-caprolactone nanoparticles containing Fe3 O4 and gemcitabine enhance anti-tumor effect in pancreatic cancer xenograft mouse model

Jingu Gang, Seong Bae Park, Woochan Hyung, Eric H. Choi, Jing Wen, Han Soo Kim, Young Gun Shul, Seungjoo Haam, Si Young Song

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

We prepared magnetic (Fe3O4) poly ε-caprolactone (PCL) nanoparticles (mean diameter 164 ± 3 nm) containing an anticancer drug (gemcitabine) using emulsion-diffusion method in order to develop more efficient drug delivery for cancer treatment. Nanoparticles were smooth, well individualized and homogeneous in size. The values of magnetizations for the magnetic PCL nanoparticles were observed around 10.2 emu/g at 2000 Oe magnetic field intensity and showed super-paramagnetic property. In case of the drug, the drug loading contents was 18.6% and entrapment efficiency was 52.2%. The anti-tumor effects caused by these particles were examined using nude mice bearing subcutaneous human pancreatic adenocarcinoma cells (HPAC) in vivo. We divided that these mice were randomly assigned to one of five treatment groups for experimental contrast. The antitumor effect was showed with 15-fold higher dose when compared to free gemcitabine. From the result, the magnetic PCL nanoparticles may provide a therapeutic benefit by delivering drugs efficiently to magnetically targeted tumor tissues, thus achieving safe and successful anti-tumor effects with low toxicity.

Original languageEnglish
Pages (from-to)445-453
Number of pages9
JournalJournal of drug targeting
Volume15
Issue number6
DOIs
Publication statusPublished - 2007 Jul

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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