Magnetic resonance imaging contrast agents comprising zinc-containing magnetic metal oxide nanoparticles

Jinwoo Cheon (Inventor)

Research output: Patent

Abstract

The present invention relates to an MRI contrast agent that includes zinc-containing water-soluble metal oxide nanoparticles and has an improved contrast effect. The zinc-containing water-soluble metal oxide nanoparticles are characterized by addition of zinc to a matrix comprising the metal oxide nanoparticles or by substitution of metal in the matrix, resulting in the improved contrast effect of MRI. In addition, the zinc-containing metal oxide nanoparticles of the present invention include the MRI contrast agent t having hybrid structures of "zinc-containing metal oxide nanoparticle--biologically/chemically active material" in which the nanoparticle is conjugated with a bioactive material such as proteins, antibodies, and chemical materials.
Original languageEnglish
Patent numberWO2008/127031
Publication statusPublished - 2005 Apr 11

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magnetic metals
metal oxides
magnetic resonance
zinc
nanoparticles
inventions
zinc oxides
hybrid structures
matrices
activity (biology)
antibodies
water
substitutes
proteins
metals

Cite this

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abstract = "The present invention relates to an MRI contrast agent that includes zinc-containing water-soluble metal oxide nanoparticles and has an improved contrast effect. The zinc-containing water-soluble metal oxide nanoparticles are characterized by addition of zinc to a matrix comprising the metal oxide nanoparticles or by substitution of metal in the matrix, resulting in the improved contrast effect of MRI. In addition, the zinc-containing metal oxide nanoparticles of the present invention include the MRI contrast agent t having hybrid structures of {"}zinc-containing metal oxide nanoparticle--biologically/chemically active material{"} in which the nanoparticle is conjugated with a bioactive material such as proteins, antibodies, and chemical materials.",
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AB - The present invention relates to an MRI contrast agent that includes zinc-containing water-soluble metal oxide nanoparticles and has an improved contrast effect. The zinc-containing water-soluble metal oxide nanoparticles are characterized by addition of zinc to a matrix comprising the metal oxide nanoparticles or by substitution of metal in the matrix, resulting in the improved contrast effect of MRI. In addition, the zinc-containing metal oxide nanoparticles of the present invention include the MRI contrast agent t having hybrid structures of "zinc-containing metal oxide nanoparticle--biologically/chemically active material" in which the nanoparticle is conjugated with a bioactive material such as proteins, antibodies, and chemical materials.

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