Magnetic Tandem Apoptosis for Overcoming Multidrug-Resistant Cancer

Mi Hyeon Cho, Seulmi Kim, Jae-Hyun Lee, Tae Hyun Shin, Dongwon Yoo, Jinwoo Cheon

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Multidrug resistance (MDR) is a leading cause of failure in current chemotherapy treatment and constitutes a formidable challenge in therapeutics. Here, we demonstrate that a nanoscale magnetic tandem apoptosis trigger (m-TAT), which consists of a magnetic nanoparticle and chemodrug (e.g., doxorubicin), can completely remove MDR cancer cells in both in vitro and in vivo systems. m-TAT simultaneously activates extrinsic and intrinsic apoptosis signals in a synergistic fashion and downregulates the drug efflux pump (e.g., P-glycoprotein) which is one of the main causes of MDR. The tandem apoptosis strategy uses low level of chemodrug (in the nanomolar (nM) range) to eliminate MDR cancer cells. We further demonstrate that apoptosis of MDR cancer cells can be achieved in a spatially selective manner with single-cell level precision. Our study indicates that nanoscale tandem activation of convergent signaling pathways is a new platform concept to overcome MDR with high efficacy and specificity.

Original languageEnglish
Pages (from-to)7455-7460
Number of pages6
JournalNano letters
Volume16
Issue number12
DOIs
Publication statusPublished - 2016 Dec 14

Fingerprint

apoptosis
Cell death
cancer
Apoptosis
Cells
actuators
Glycoproteins
Chemotherapy
efflux
P-Glycoprotein
causes
Doxorubicin
chemotherapy
Chemical activation
Pumps
Nanoparticles
drugs
platforms
activation
pumps

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

Cite this

Cho, Mi Hyeon ; Kim, Seulmi ; Lee, Jae-Hyun ; Shin, Tae Hyun ; Yoo, Dongwon ; Cheon, Jinwoo. / Magnetic Tandem Apoptosis for Overcoming Multidrug-Resistant Cancer. In: Nano letters. 2016 ; Vol. 16, No. 12. pp. 7455-7460.
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Magnetic Tandem Apoptosis for Overcoming Multidrug-Resistant Cancer. / Cho, Mi Hyeon; Kim, Seulmi; Lee, Jae-Hyun; Shin, Tae Hyun; Yoo, Dongwon; Cheon, Jinwoo.

In: Nano letters, Vol. 16, No. 12, 14.12.2016, p. 7455-7460.

Research output: Contribution to journalArticle

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T1 - Magnetic Tandem Apoptosis for Overcoming Multidrug-Resistant Cancer

AU - Cho, Mi Hyeon

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AU - Lee, Jae-Hyun

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AU - Yoo, Dongwon

AU - Cheon, Jinwoo

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