Magnetically triggered dual functional nanoparticles for resistance-free apoptotic hyperthermia

Dongwon Yoo; Heeyeong Jeong; Seung Hyun Noh; Jae Hyun Lee; Jinwoo Cheon

doi:10.1002/anie.201306557

Magnetically triggered dual functional nanoparticles for resistance-free apoptotic hyperthermia

Dongwon Yoo, Heeyeong Jeong, Seung Hyun Noh, Jae Hyun Lee, Jinwoo Cheon

Research output: Contribution to journal › Article › peer-review

187 Citations (Scopus)

Abstract

Overcoming resistance: Heat-treated cancer cells possess a protective mechanism for resistance and survival. Resistance-free apoptosis-inducing magnetic nanoparticles (RAINs) successfully promote hyperthermic apoptosis, obstructing cell survival by triggering two functional units of heat generation and the release of geldanamycin (GM) for heat shock protein (Hsp) inhibition under an alternating magnetic field (AMF).

Original language	English
Pages (from-to)	13047-13051
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	49
DOIs	https://doi.org/10.1002/anie.201306557
Publication status	Published - 2013 Dec 2

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201306557

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title = "Magnetically triggered dual functional nanoparticles for resistance-free apoptotic hyperthermia",

abstract = "Overcoming resistance: Heat-treated cancer cells possess a protective mechanism for resistance and survival. Resistance-free apoptosis-inducing magnetic nanoparticles (RAINs) successfully promote hyperthermic apoptosis, obstructing cell survival by triggering two functional units of heat generation and the release of geldanamycin (GM) for heat shock protein (Hsp) inhibition under an alternating magnetic field (AMF).",

author = "Dongwon Yoo and Heeyeong Jeong and Noh, {Seung Hyun} and Lee, {Jae Hyun} and Jinwoo Cheon",

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AU - Yoo, Dongwon

AU - Jeong, Heeyeong

AU - Noh, Seung Hyun

AU - Lee, Jae Hyun

AU - Cheon, Jinwoo

PY - 2013/12/2

Y1 - 2013/12/2

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M3 - Article

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Magnetically triggered dual functional nanoparticles for resistance-free apoptotic hyperthermia

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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