Magnetically triggered dual functional nanoparticles for resistance-free apoptotic hyperthermia

Dongwon Yoo, Heeyeong Jeong, Seung Hyun Noh, Jae Hyun Lee, Jinwoo Cheon

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Overcoming resistance: Heat-treated cancer cells possess a protective mechanism for resistance and survival. Resistance-free apoptosis-inducing magnetic nanoparticles (RAINs) successfully promote hyperthermic apoptosis, obstructing cell survival by triggering two functional units of heat generation and the release of geldanamycin (GM) for heat shock protein (Hsp) inhibition under an alternating magnetic field (AMF).

Original languageEnglish
Pages (from-to)13047-13051
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number49
DOIs
Publication statusPublished - 2013 Dec 2

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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