Magnetically triggered dual functional nanoparticles for resistance-free apoptotic hyperthermia

Dongwon Yoo, Heeyeong Jeong, Seung Hyun Noh, Jae-Hyun Lee, Jinwoo Cheon

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Overcoming resistance: Heat-treated cancer cells possess a protective mechanism for resistance and survival. Resistance-free apoptosis-inducing magnetic nanoparticles (RAINs) successfully promote hyperthermic apoptosis, obstructing cell survival by triggering two functional units of heat generation and the release of geldanamycin (GM) for heat shock protein (Hsp) inhibition under an alternating magnetic field (AMF).

Original languageEnglish
Pages (from-to)13047-13051
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number49
DOIs
Publication statusPublished - 2013 Dec 2

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Cell death
Cells
Apoptosis
Nanoparticles
Heat generation
Heat-Shock Proteins
Heat resistance
Magnetic fields
Proteins
Hot Temperature
geldanamycin

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

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Magnetically triggered dual functional nanoparticles for resistance-free apoptotic hyperthermia. / Yoo, Dongwon; Jeong, Heeyeong; Noh, Seung Hyun; Lee, Jae-Hyun; Cheon, Jinwoo.

In: Angewandte Chemie - International Edition, Vol. 52, No. 49, 02.12.2013, p. 13047-13051.

Research output: Contribution to journalArticle

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AU - Noh, Seung Hyun

AU - Lee, Jae-Hyun

AU - Cheon, Jinwoo

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