Magnetoencephalography as a Prognostic Tool in Patients with Medically Intractable Temporal Lobe Epilepsy

Chang Kyu Park, Su Jeong Hwang, Na Young Jung, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang

Research output: Contribution to journalArticle

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Abstract

Background: Most surgical treatments for medically intractable temporal lobe epilepsy are helpful. When a patient has persistent symptoms after surgery, there are no tests that accurately predict whether a patient will have remnant epileptic foci. The aim of this study was to evaluate the usefulness of magnetoencephalography (MEG) as a prognostic tool in patients with temporal lobe epilepsy. Methods: From July 2012 to July 2016, 21 patients underwent preoperative and postoperative MEG at our center. Postoperative MEG was performed within 2 weeks after surgery. We analyzed MEG by estimating the time-frequency component of the signal to define gamma oscillations (GOs), which are an indicator of epileptogenic foci. We analyzed the relationship between GOs on MEG and surgical outcomes. Results: Mean follow-up period was 28.3 months (range, 13–44 months). At the last follow-up visit, patients were divided into 2 groups according to surgical outcome. All patients showed spike waves and GOs on preoperative electroencephalography and MEG. In the seizure control group (16 patients), spike waves (2 patients) and GOs (2 patients) were seen postoperatively despite absence of symptoms. In the recurrent seizure group (5 patients), whereas 3 patients showed spike waves, all 5 patients showed GOs on MEG postoperatively. There was a significant association between presence of GOs on postoperative MEG and surgical outcome (P = 0.01). Conclusions: MEG can provide valuable postsurgical information on epileptic foci in patients with recurrent symptoms; GOs on postoperative MEG were especially correlated with epileptic recurrence. Our data show that GOs on postoperative MEG may have prognostic value.

Original languageEnglish
Pages (from-to)e753-e759
JournalWorld Neurosurgery
Volume123
DOIs
Publication statusPublished - 2019 Mar

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Magnetoencephalography
Temporal Lobe Epilepsy
Drug Resistant Epilepsy
Seizures
Electroencephalography

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Park, Chang Kyu ; Hwang, Su Jeong ; Jung, Na Young ; Chang, Won Seok ; Jung, Hyun Ho ; Chang, Jin Woo. / Magnetoencephalography as a Prognostic Tool in Patients with Medically Intractable Temporal Lobe Epilepsy. In: World Neurosurgery. 2019 ; Vol. 123. pp. e753-e759.
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abstract = "Background: Most surgical treatments for medically intractable temporal lobe epilepsy are helpful. When a patient has persistent symptoms after surgery, there are no tests that accurately predict whether a patient will have remnant epileptic foci. The aim of this study was to evaluate the usefulness of magnetoencephalography (MEG) as a prognostic tool in patients with temporal lobe epilepsy. Methods: From July 2012 to July 2016, 21 patients underwent preoperative and postoperative MEG at our center. Postoperative MEG was performed within 2 weeks after surgery. We analyzed MEG by estimating the time-frequency component of the signal to define gamma oscillations (GOs), which are an indicator of epileptogenic foci. We analyzed the relationship between GOs on MEG and surgical outcomes. Results: Mean follow-up period was 28.3 months (range, 13–44 months). At the last follow-up visit, patients were divided into 2 groups according to surgical outcome. All patients showed spike waves and GOs on preoperative electroencephalography and MEG. In the seizure control group (16 patients), spike waves (2 patients) and GOs (2 patients) were seen postoperatively despite absence of symptoms. In the recurrent seizure group (5 patients), whereas 3 patients showed spike waves, all 5 patients showed GOs on MEG postoperatively. There was a significant association between presence of GOs on postoperative MEG and surgical outcome (P = 0.01). Conclusions: MEG can provide valuable postsurgical information on epileptic foci in patients with recurrent symptoms; GOs on postoperative MEG were especially correlated with epileptic recurrence. Our data show that GOs on postoperative MEG may have prognostic value.",
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Magnetoencephalography as a Prognostic Tool in Patients with Medically Intractable Temporal Lobe Epilepsy. / Park, Chang Kyu; Hwang, Su Jeong; Jung, Na Young; Chang, Won Seok; Jung, Hyun Ho; Chang, Jin Woo.

In: World Neurosurgery, Vol. 123, 03.2019, p. e753-e759.

Research output: Contribution to journalArticle

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