Magnetoplex based on MnFe2O4 nanocrystals for magnetic labeling and MR imaging of human mesenchymal stem cells

Jaemoon Yang, Eun Kyung Lim, Eun Sook Lee, Jinsuck Suh, Seungjoo Haam, yongmin Huh

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

For efficient labeling and tracking via magnetic resonance (MR) imaging of human mesenchymal stem cells (h-MSCs), magnetic labeling agents must be responsive to an external magnetic field. Thus, we developed ultrasensitive magnetoplex as a magnetic labeling agent composed of PEGylated MnFe 2O4 nanocrystals (PMNCs) and polycationics (poly-L-lysine, PLL) for efficient labeling of the h- MSCs and monitoring of the transplanted h-MSCs for a long term. PMNCs were prepared by nanoemulsion methods composed of MnFe2O4 nanocrystals (MNCs) and amphiphilic polymers (mPEG-dodecanoic acid). The prepared PMNCs exhibited excellent biocompatibility and their polycationic complexes (PMNCs/ PLL) demonstrated remarkable sensitivity compared with magnetic iron oxide nanoparticles (MION)/PLL or Ferumoxides/PLL. Furthermore, PMNCs demonstrated the potentials for novel diagnostic and therapeutic strategies with potential applications in various biomedical fields.

Original languageEnglish
Pages (from-to)1275-1283
Number of pages9
JournalJournal of Nanoparticle Research
Volume12
Issue number4
DOIs
Publication statusPublished - 2010 May 1

Fingerprint

Stem Cells
Nanocrystals
stem cells
Magnetic Resonance Imaging
Magnetic resonance
Stem cells
Labeling
marking
magnetic resonance
nanocrystals
lysine
Imaging techniques
Lysine
lauric acid
biocompatibility
Iron oxides
Biocompatibility
iron oxides
Iron
External Field

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Chemistry(all)
  • Modelling and Simulation
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

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abstract = "For efficient labeling and tracking via magnetic resonance (MR) imaging of human mesenchymal stem cells (h-MSCs), magnetic labeling agents must be responsive to an external magnetic field. Thus, we developed ultrasensitive magnetoplex as a magnetic labeling agent composed of PEGylated MnFe 2O4 nanocrystals (PMNCs) and polycationics (poly-L-lysine, PLL) for efficient labeling of the h- MSCs and monitoring of the transplanted h-MSCs for a long term. PMNCs were prepared by nanoemulsion methods composed of MnFe2O4 nanocrystals (MNCs) and amphiphilic polymers (mPEG-dodecanoic acid). The prepared PMNCs exhibited excellent biocompatibility and their polycationic complexes (PMNCs/ PLL) demonstrated remarkable sensitivity compared with magnetic iron oxide nanoparticles (MION)/PLL or Ferumoxides/PLL. Furthermore, PMNCs demonstrated the potentials for novel diagnostic and therapeutic strategies with potential applications in various biomedical fields.",
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Magnetoplex based on MnFe2O4 nanocrystals for magnetic labeling and MR imaging of human mesenchymal stem cells. / Yang, Jaemoon; Lim, Eun Kyung; Lee, Eun Sook; Suh, Jinsuck; Haam, Seungjoo; Huh, yongmin.

In: Journal of Nanoparticle Research, Vol. 12, No. 4, 01.05.2010, p. 1275-1283.

Research output: Contribution to journalArticle

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AU - Yang, Jaemoon

AU - Lim, Eun Kyung

AU - Lee, Eun Sook

AU - Suh, Jinsuck

AU - Haam, Seungjoo

AU - Huh, yongmin

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