Abstract
Aim: Several studies have implicated increased risk of malignancy in patients with immunoglobulin G4-related disease (IgG4-RD). Hence, we first evaluated the risk and the type of malignancy in Korean IgG4-RD patients. Method: Clinical and laboratory results of patients fulfilling the comprehensive diagnostic criteria for IgG4-RD were retrospectively collected between January 2006 and November 2015. One hundred and eighteen patients were included, and 35 were classified as having definite, 83 as possible/probable IgG4-RD. We compared baseline clinical and laboratory variables between patients with definite and those with possible/probable IgG4-RD and calculated standardized incidence ratios (SIRs) for malignancies. Results: The median age was 60 years old and 91 patients (77.1%) were male. Malignancies were found in 12 of 118 patients (10.1%), and lymphoma (4, 25.0%) was the most frequent malignancy related to IgG4-RD. Definite IgG4-RD patients had higher serum IgG levels and frequent multiple organ involvement. The overall incidence of malignancy was increased in patients with IgG4-RD compared to the general population (SIR 23.08 [95% CI 11.92–40.31]), and the overall risk of SIRs was highest in non-Hodgkin lymphoma (SIR 400.00 [95% CI 109.00–1024.00]). Conclusion: Our data showed that increased risk of malignancy, especially lymphomas, was observed in Korean IgG4-RD patients.
| Original language | English |
|---|---|
| Pages (from-to) | 1028-1035 |
| Number of pages | 8 |
| Journal | International Journal of Rheumatic Diseases |
| Volume | 20 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2017 Aug |
Fingerprint
All Science Journal Classification (ASJC) codes
- Rheumatology
Cite this
}
Malignancies in Korean patients with immunoglobulin G4-related disease. / Ahn, Sung Soo; Song, Jason Jungsik; Park, Yong Beom; Lee, Sang Won.
In: International Journal of Rheumatic Diseases, Vol. 20, No. 8, 08.2017, p. 1028-1035.Research output: Contribution to journal › Article
TY - JOUR
T1 - Malignancies in Korean patients with immunoglobulin G4-related disease
AU - Ahn, Sung Soo
AU - Song, Jason Jungsik
AU - Park, Yong Beom
AU - Lee, Sang Won
PY - 2017/8
Y1 - 2017/8
N2 - Aim: Several studies have implicated increased risk of malignancy in patients with immunoglobulin G4-related disease (IgG4-RD). Hence, we first evaluated the risk and the type of malignancy in Korean IgG4-RD patients. Method: Clinical and laboratory results of patients fulfilling the comprehensive diagnostic criteria for IgG4-RD were retrospectively collected between January 2006 and November 2015. One hundred and eighteen patients were included, and 35 were classified as having definite, 83 as possible/probable IgG4-RD. We compared baseline clinical and laboratory variables between patients with definite and those with possible/probable IgG4-RD and calculated standardized incidence ratios (SIRs) for malignancies. Results: The median age was 60 years old and 91 patients (77.1%) were male. Malignancies were found in 12 of 118 patients (10.1%), and lymphoma (4, 25.0%) was the most frequent malignancy related to IgG4-RD. Definite IgG4-RD patients had higher serum IgG levels and frequent multiple organ involvement. The overall incidence of malignancy was increased in patients with IgG4-RD compared to the general population (SIR 23.08 [95% CI 11.92–40.31]), and the overall risk of SIRs was highest in non-Hodgkin lymphoma (SIR 400.00 [95% CI 109.00–1024.00]). Conclusion: Our data showed that increased risk of malignancy, especially lymphomas, was observed in Korean IgG4-RD patients.
AB - Aim: Several studies have implicated increased risk of malignancy in patients with immunoglobulin G4-related disease (IgG4-RD). Hence, we first evaluated the risk and the type of malignancy in Korean IgG4-RD patients. Method: Clinical and laboratory results of patients fulfilling the comprehensive diagnostic criteria for IgG4-RD were retrospectively collected between January 2006 and November 2015. One hundred and eighteen patients were included, and 35 were classified as having definite, 83 as possible/probable IgG4-RD. We compared baseline clinical and laboratory variables between patients with definite and those with possible/probable IgG4-RD and calculated standardized incidence ratios (SIRs) for malignancies. Results: The median age was 60 years old and 91 patients (77.1%) were male. Malignancies were found in 12 of 118 patients (10.1%), and lymphoma (4, 25.0%) was the most frequent malignancy related to IgG4-RD. Definite IgG4-RD patients had higher serum IgG levels and frequent multiple organ involvement. The overall incidence of malignancy was increased in patients with IgG4-RD compared to the general population (SIR 23.08 [95% CI 11.92–40.31]), and the overall risk of SIRs was highest in non-Hodgkin lymphoma (SIR 400.00 [95% CI 109.00–1024.00]). Conclusion: Our data showed that increased risk of malignancy, especially lymphomas, was observed in Korean IgG4-RD patients.
UR - http://www.scopus.com/inward/record.url?scp=85028574554&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85028574554&partnerID=8YFLogxK
U2 - 10.1111/1756-185X.13093
DO - 10.1111/1756-185X.13093
M3 - Article
C2 - 28544157
AN - SCOPUS:85028574554
VL - 20
SP - 1028
EP - 1035
JO - International Journal of Rheumatic Diseases
JF - International Journal of Rheumatic Diseases
SN - 1756-1841
IS - 8
ER -