Malignancies in Korean patients with immunoglobulin G4-related disease

Sung Soo Ahn, Jason Jungsik Song, Yong Beom Park, Sang Won Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Aim: Several studies have implicated increased risk of malignancy in patients with immunoglobulin G4-related disease (IgG4-RD). Hence, we first evaluated the risk and the type of malignancy in Korean IgG4-RD patients. Method: Clinical and laboratory results of patients fulfilling the comprehensive diagnostic criteria for IgG4-RD were retrospectively collected between January 2006 and November 2015. One hundred and eighteen patients were included, and 35 were classified as having definite, 83 as possible/probable IgG4-RD. We compared baseline clinical and laboratory variables between patients with definite and those with possible/probable IgG4-RD and calculated standardized incidence ratios (SIRs) for malignancies. Results: The median age was 60 years old and 91 patients (77.1%) were male. Malignancies were found in 12 of 118 patients (10.1%), and lymphoma (4, 25.0%) was the most frequent malignancy related to IgG4-RD. Definite IgG4-RD patients had higher serum IgG levels and frequent multiple organ involvement. The overall incidence of malignancy was increased in patients with IgG4-RD compared to the general population (SIR 23.08 [95% CI 11.92–40.31]), and the overall risk of SIRs was highest in non-Hodgkin lymphoma (SIR 400.00 [95% CI 109.00–1024.00]). Conclusion: Our data showed that increased risk of malignancy, especially lymphomas, was observed in Korean IgG4-RD patients.

Original languageEnglish
Pages (from-to)1028-1035
Number of pages8
JournalInternational Journal of Rheumatic Diseases
Volume20
Issue number8
DOIs
Publication statusPublished - 2017 Aug

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Immunoglobulins
Neoplasms
Incidence
Lymphoma
Non-Hodgkin's Lymphoma
Immunoglobulin G
Serum
Population

All Science Journal Classification (ASJC) codes

  • Rheumatology

Cite this

Ahn, Sung Soo ; Song, Jason Jungsik ; Park, Yong Beom ; Lee, Sang Won. / Malignancies in Korean patients with immunoglobulin G4-related disease. In: International Journal of Rheumatic Diseases. 2017 ; Vol. 20, No. 8. pp. 1028-1035.
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abstract = "Aim: Several studies have implicated increased risk of malignancy in patients with immunoglobulin G4-related disease (IgG4-RD). Hence, we first evaluated the risk and the type of malignancy in Korean IgG4-RD patients. Method: Clinical and laboratory results of patients fulfilling the comprehensive diagnostic criteria for IgG4-RD were retrospectively collected between January 2006 and November 2015. One hundred and eighteen patients were included, and 35 were classified as having definite, 83 as possible/probable IgG4-RD. We compared baseline clinical and laboratory variables between patients with definite and those with possible/probable IgG4-RD and calculated standardized incidence ratios (SIRs) for malignancies. Results: The median age was 60 years old and 91 patients (77.1{\%}) were male. Malignancies were found in 12 of 118 patients (10.1{\%}), and lymphoma (4, 25.0{\%}) was the most frequent malignancy related to IgG4-RD. Definite IgG4-RD patients had higher serum IgG levels and frequent multiple organ involvement. The overall incidence of malignancy was increased in patients with IgG4-RD compared to the general population (SIR 23.08 [95{\%} CI 11.92–40.31]), and the overall risk of SIRs was highest in non-Hodgkin lymphoma (SIR 400.00 [95{\%} CI 109.00–1024.00]). Conclusion: Our data showed that increased risk of malignancy, especially lymphomas, was observed in Korean IgG4-RD patients.",
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Malignancies in Korean patients with immunoglobulin G4-related disease. / Ahn, Sung Soo; Song, Jason Jungsik; Park, Yong Beom; Lee, Sang Won.

In: International Journal of Rheumatic Diseases, Vol. 20, No. 8, 08.2017, p. 1028-1035.

Research output: Contribution to journalArticle

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