Malignancy risk and characteristics of thyroid nodules with two consecutive results of atypia of undetermined significance or follicular lesion of undetermined significance on cytology

Vivian Youngjean Park, Eunkyung Kim, jinyoung kwak, Jung Hyun Yoon, Hee Jung Moon

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21 Citations (Scopus)

Abstract

Purpose: To evaluate the malignancy risk and characteristics of thyroid nodules with two “Atypia of Undetermined Significance” or “Follicular Lesion of Undetermined Significance” (AUS/FLUS) results, and compare characteristics of malignancies with two AUS/FLUS results to those with one AUS/FLUS result. Methods: Of 441 thyroid nodules with initial AUS/FLUS results, 236 underwent repeat fine-needle-aspiration (FNA), with 58 obtaining repeated AUS/FLUS results. Thyroid Imaging Reporting and Data System (TIRADS) categories were assigned, and clinico-pathological characteristics were compared between benign and malignant nodules and between malignancies with two consecutive AUS/FLUS results and those with one AUS/FLUS result. Results: Thirty-one percent (18/58) of nodules with two AUS/FLUS results and 58.1 % (18/31) of confirmed nodules were malignant. Age, gender, nodule size, ultrasound features and TIRADS categories did not differ between benign and malignant nodules or between malignancies with one and two AUS/FLUS results. Malignancies with two AUS/FLUS results had a higher proportion of a follicular variant of papillary thyroid carcinoma (PTC) (46.7 % vs. 13.6 %, P = 0.009). Conclusions: Thyroid nodules with two AUS/FLUS results had a high malignancy risk of at least 31.0 % and a higher proportion of a follicular variant of PTC. Surgery should be considered regardless of ultrasound features. Key Points: • Thyroid nodules with two consecutive AUS/FLUS results had a high malignancy risk. • Ultrasound features are less useful in nodules with two AUS/FLUS results. • The follicular variant of PTC is more frequent in malignancies with two AUS/FLUS results.

Original languageEnglish
Pages (from-to)2601-2607
Number of pages7
JournalEuropean Radiology
Volume25
Issue number9
DOIs
Publication statusPublished - 2015 Sep 10

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Thyroid Nodule
Cell Biology
Neoplasms
Information Systems
Thyroid Gland
Fine Needle Biopsy

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Malignancy risk and characteristics of thyroid nodules with two consecutive results of atypia of undetermined significance or follicular lesion of undetermined significance on cytology",
abstract = "Purpose: To evaluate the malignancy risk and characteristics of thyroid nodules with two “Atypia of Undetermined Significance” or “Follicular Lesion of Undetermined Significance” (AUS/FLUS) results, and compare characteristics of malignancies with two AUS/FLUS results to those with one AUS/FLUS result. Methods: Of 441 thyroid nodules with initial AUS/FLUS results, 236 underwent repeat fine-needle-aspiration (FNA), with 58 obtaining repeated AUS/FLUS results. Thyroid Imaging Reporting and Data System (TIRADS) categories were assigned, and clinico-pathological characteristics were compared between benign and malignant nodules and between malignancies with two consecutive AUS/FLUS results and those with one AUS/FLUS result. Results: Thirty-one percent (18/58) of nodules with two AUS/FLUS results and 58.1 {\%} (18/31) of confirmed nodules were malignant. Age, gender, nodule size, ultrasound features and TIRADS categories did not differ between benign and malignant nodules or between malignancies with one and two AUS/FLUS results. Malignancies with two AUS/FLUS results had a higher proportion of a follicular variant of papillary thyroid carcinoma (PTC) (46.7 {\%} vs. 13.6 {\%}, P = 0.009). Conclusions: Thyroid nodules with two AUS/FLUS results had a high malignancy risk of at least 31.0 {\%} and a higher proportion of a follicular variant of PTC. Surgery should be considered regardless of ultrasound features. Key Points: • Thyroid nodules with two consecutive AUS/FLUS results had a high malignancy risk. • Ultrasound features are less useful in nodules with two AUS/FLUS results. • The follicular variant of PTC is more frequent in malignancies with two AUS/FLUS results.",
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Malignancy risk and characteristics of thyroid nodules with two consecutive results of atypia of undetermined significance or follicular lesion of undetermined significance on cytology. / Park, Vivian Youngjean; Kim, Eunkyung; kwak, jinyoung; Yoon, Jung Hyun; Moon, Hee Jung.

In: European Radiology, Vol. 25, No. 9, 10.09.2015, p. 2601-2607.

Research output: Contribution to journalArticle

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AB - Purpose: To evaluate the malignancy risk and characteristics of thyroid nodules with two “Atypia of Undetermined Significance” or “Follicular Lesion of Undetermined Significance” (AUS/FLUS) results, and compare characteristics of malignancies with two AUS/FLUS results to those with one AUS/FLUS result. Methods: Of 441 thyroid nodules with initial AUS/FLUS results, 236 underwent repeat fine-needle-aspiration (FNA), with 58 obtaining repeated AUS/FLUS results. Thyroid Imaging Reporting and Data System (TIRADS) categories were assigned, and clinico-pathological characteristics were compared between benign and malignant nodules and between malignancies with two consecutive AUS/FLUS results and those with one AUS/FLUS result. Results: Thirty-one percent (18/58) of nodules with two AUS/FLUS results and 58.1 % (18/31) of confirmed nodules were malignant. Age, gender, nodule size, ultrasound features and TIRADS categories did not differ between benign and malignant nodules or between malignancies with one and two AUS/FLUS results. Malignancies with two AUS/FLUS results had a higher proportion of a follicular variant of papillary thyroid carcinoma (PTC) (46.7 % vs. 13.6 %, P = 0.009). Conclusions: Thyroid nodules with two AUS/FLUS results had a high malignancy risk of at least 31.0 % and a higher proportion of a follicular variant of PTC. Surgery should be considered regardless of ultrasound features. Key Points: • Thyroid nodules with two consecutive AUS/FLUS results had a high malignancy risk. • Ultrasound features are less useful in nodules with two AUS/FLUS results. • The follicular variant of PTC is more frequent in malignancies with two AUS/FLUS results.

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