Malignant and borderline phyllodes tumors of the breast: a multicenter study of 362 patients (KROG 16-08)

Noorie Choi, Kyubo Kim, Kyung Hwan Shin, Yumi Kim, Hyeong Gon Moon, Won Park, Doo Ho Choi, Su Ssan Kim, Seung Do Ahn, Tae Hyun Kim, Mison Chun, Yong Bae Kim, Suzy Kim, Byung Ock Choi, Jin Hee Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose: To identify risk factors for local recurrence (LR) and investigate roles of adjuvant local therapy for malignant and borderline phyllodes tumors of the breast. Methods: From 1981 to 2014, 362 patients with malignant (n = 235) and borderline (n = 127) phyllodes tumors were treated by breast-conserving surgery (BCS) or total mastectomy (TM) at 10 centers. Thirty-one patients received adjuvant radiation therapy (RT), and those who received adjuvant chemotherapy were excluded from the study. Results: Median follow-up was 5 years. LR developed in 60 (16.6%) patients. Regional recurrence occurred in 2 (0.6%) patients and distant metastasis (DM) developed in 19 (5.2%) patients. Patients receiving BCS (p = 0.025) and those not undergoing adjuvant RT (p = 0.041) showed higher LR rates. For malignant subtypes, local control (LC) rates at 5 years for BCS alone, BCS with adjuvant RT, TM alone, and TM with adjuvant RT were 80.7, 93.3, 92.4, and 100%, respectively (p = 0.033). Multivariate analyses revealed BCS alone, tumor size ≥ 5 cm, and positive margins as independent risk factors for LR. Margin-positive BCS alone showed poorest LC regardless of tumor size (62.5%, p = 0.007). For margin-negative BCS alone, 5-year LC rates for tumors ≥ 5 cm versus those < 5 cm were 71.8% versus 89.5% (p = 0.012). For borderline subtypes, only positive margins (p = 0.044) independently increased the risk of LR. DM developed exclusively in malignant subtypes and a prior LR event increased the risk of DM by sixfold (HR 6.2, 95% CI 1.6–16.1, p = 0.001). Conclusions: Malignant and borderline phyllodes tumors with positive margins after surgery have high LR rates. After treatment by margin-negative BCS alone, patients with large malignant phyllodes tumors ≥ 5 cm also have heightened risk of LR. Thus, such patients should be considered for additional local therapy.

Original languageEnglish
Pages (from-to)335-344
Number of pages10
JournalBreast Cancer Research and Treatment
Volume171
Issue number2
DOIs
Publication statusPublished - 2018 Sep 1

Fingerprint

Phyllodes Tumor
Segmental Mastectomy
Multicenter Studies
Breast
Recurrence
Simple Mastectomy
Radiotherapy
Neoplasm Metastasis
Neoplasms
Adjuvant Chemotherapy
Therapeutics
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Choi, Noorie ; Kim, Kyubo ; Shin, Kyung Hwan ; Kim, Yumi ; Moon, Hyeong Gon ; Park, Won ; Choi, Doo Ho ; Kim, Su Ssan ; Ahn, Seung Do ; Kim, Tae Hyun ; Chun, Mison ; Kim, Yong Bae ; Kim, Suzy ; Choi, Byung Ock ; Kim, Jin Hee. / Malignant and borderline phyllodes tumors of the breast : a multicenter study of 362 patients (KROG 16-08). In: Breast Cancer Research and Treatment. 2018 ; Vol. 171, No. 2. pp. 335-344.
@article{913c92913c3741ccac832ceb556d624c,
title = "Malignant and borderline phyllodes tumors of the breast: a multicenter study of 362 patients (KROG 16-08)",
abstract = "Purpose: To identify risk factors for local recurrence (LR) and investigate roles of adjuvant local therapy for malignant and borderline phyllodes tumors of the breast. Methods: From 1981 to 2014, 362 patients with malignant (n = 235) and borderline (n = 127) phyllodes tumors were treated by breast-conserving surgery (BCS) or total mastectomy (TM) at 10 centers. Thirty-one patients received adjuvant radiation therapy (RT), and those who received adjuvant chemotherapy were excluded from the study. Results: Median follow-up was 5 years. LR developed in 60 (16.6{\%}) patients. Regional recurrence occurred in 2 (0.6{\%}) patients and distant metastasis (DM) developed in 19 (5.2{\%}) patients. Patients receiving BCS (p = 0.025) and those not undergoing adjuvant RT (p = 0.041) showed higher LR rates. For malignant subtypes, local control (LC) rates at 5 years for BCS alone, BCS with adjuvant RT, TM alone, and TM with adjuvant RT were 80.7, 93.3, 92.4, and 100{\%}, respectively (p = 0.033). Multivariate analyses revealed BCS alone, tumor size ≥ 5 cm, and positive margins as independent risk factors for LR. Margin-positive BCS alone showed poorest LC regardless of tumor size (62.5{\%}, p = 0.007). For margin-negative BCS alone, 5-year LC rates for tumors ≥ 5 cm versus those < 5 cm were 71.8{\%} versus 89.5{\%} (p = 0.012). For borderline subtypes, only positive margins (p = 0.044) independently increased the risk of LR. DM developed exclusively in malignant subtypes and a prior LR event increased the risk of DM by sixfold (HR 6.2, 95{\%} CI 1.6–16.1, p = 0.001). Conclusions: Malignant and borderline phyllodes tumors with positive margins after surgery have high LR rates. After treatment by margin-negative BCS alone, patients with large malignant phyllodes tumors ≥ 5 cm also have heightened risk of LR. Thus, such patients should be considered for additional local therapy.",
author = "Noorie Choi and Kyubo Kim and Shin, {Kyung Hwan} and Yumi Kim and Moon, {Hyeong Gon} and Won Park and Choi, {Doo Ho} and Kim, {Su Ssan} and Ahn, {Seung Do} and Kim, {Tae Hyun} and Mison Chun and Kim, {Yong Bae} and Suzy Kim and Choi, {Byung Ock} and Kim, {Jin Hee}",
year = "2018",
month = "9",
day = "1",
doi = "10.1007/s10549-018-4838-3",
language = "English",
volume = "171",
pages = "335--344",
journal = "Breast Cancer Research and Treatment",
issn = "0167-6806",
publisher = "Springer New York",
number = "2",

}

Choi, N, Kim, K, Shin, KH, Kim, Y, Moon, HG, Park, W, Choi, DH, Kim, SS, Ahn, SD, Kim, TH, Chun, M, Kim, YB, Kim, S, Choi, BO & Kim, JH 2018, 'Malignant and borderline phyllodes tumors of the breast: a multicenter study of 362 patients (KROG 16-08)', Breast Cancer Research and Treatment, vol. 171, no. 2, pp. 335-344. https://doi.org/10.1007/s10549-018-4838-3

Malignant and borderline phyllodes tumors of the breast : a multicenter study of 362 patients (KROG 16-08). / Choi, Noorie; Kim, Kyubo; Shin, Kyung Hwan; Kim, Yumi; Moon, Hyeong Gon; Park, Won; Choi, Doo Ho; Kim, Su Ssan; Ahn, Seung Do; Kim, Tae Hyun; Chun, Mison; Kim, Yong Bae; Kim, Suzy; Choi, Byung Ock; Kim, Jin Hee.

In: Breast Cancer Research and Treatment, Vol. 171, No. 2, 01.09.2018, p. 335-344.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Malignant and borderline phyllodes tumors of the breast

T2 - a multicenter study of 362 patients (KROG 16-08)

AU - Choi, Noorie

AU - Kim, Kyubo

AU - Shin, Kyung Hwan

AU - Kim, Yumi

AU - Moon, Hyeong Gon

AU - Park, Won

AU - Choi, Doo Ho

AU - Kim, Su Ssan

AU - Ahn, Seung Do

AU - Kim, Tae Hyun

AU - Chun, Mison

AU - Kim, Yong Bae

AU - Kim, Suzy

AU - Choi, Byung Ock

AU - Kim, Jin Hee

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Purpose: To identify risk factors for local recurrence (LR) and investigate roles of adjuvant local therapy for malignant and borderline phyllodes tumors of the breast. Methods: From 1981 to 2014, 362 patients with malignant (n = 235) and borderline (n = 127) phyllodes tumors were treated by breast-conserving surgery (BCS) or total mastectomy (TM) at 10 centers. Thirty-one patients received adjuvant radiation therapy (RT), and those who received adjuvant chemotherapy were excluded from the study. Results: Median follow-up was 5 years. LR developed in 60 (16.6%) patients. Regional recurrence occurred in 2 (0.6%) patients and distant metastasis (DM) developed in 19 (5.2%) patients. Patients receiving BCS (p = 0.025) and those not undergoing adjuvant RT (p = 0.041) showed higher LR rates. For malignant subtypes, local control (LC) rates at 5 years for BCS alone, BCS with adjuvant RT, TM alone, and TM with adjuvant RT were 80.7, 93.3, 92.4, and 100%, respectively (p = 0.033). Multivariate analyses revealed BCS alone, tumor size ≥ 5 cm, and positive margins as independent risk factors for LR. Margin-positive BCS alone showed poorest LC regardless of tumor size (62.5%, p = 0.007). For margin-negative BCS alone, 5-year LC rates for tumors ≥ 5 cm versus those < 5 cm were 71.8% versus 89.5% (p = 0.012). For borderline subtypes, only positive margins (p = 0.044) independently increased the risk of LR. DM developed exclusively in malignant subtypes and a prior LR event increased the risk of DM by sixfold (HR 6.2, 95% CI 1.6–16.1, p = 0.001). Conclusions: Malignant and borderline phyllodes tumors with positive margins after surgery have high LR rates. After treatment by margin-negative BCS alone, patients with large malignant phyllodes tumors ≥ 5 cm also have heightened risk of LR. Thus, such patients should be considered for additional local therapy.

AB - Purpose: To identify risk factors for local recurrence (LR) and investigate roles of adjuvant local therapy for malignant and borderline phyllodes tumors of the breast. Methods: From 1981 to 2014, 362 patients with malignant (n = 235) and borderline (n = 127) phyllodes tumors were treated by breast-conserving surgery (BCS) or total mastectomy (TM) at 10 centers. Thirty-one patients received adjuvant radiation therapy (RT), and those who received adjuvant chemotherapy were excluded from the study. Results: Median follow-up was 5 years. LR developed in 60 (16.6%) patients. Regional recurrence occurred in 2 (0.6%) patients and distant metastasis (DM) developed in 19 (5.2%) patients. Patients receiving BCS (p = 0.025) and those not undergoing adjuvant RT (p = 0.041) showed higher LR rates. For malignant subtypes, local control (LC) rates at 5 years for BCS alone, BCS with adjuvant RT, TM alone, and TM with adjuvant RT were 80.7, 93.3, 92.4, and 100%, respectively (p = 0.033). Multivariate analyses revealed BCS alone, tumor size ≥ 5 cm, and positive margins as independent risk factors for LR. Margin-positive BCS alone showed poorest LC regardless of tumor size (62.5%, p = 0.007). For margin-negative BCS alone, 5-year LC rates for tumors ≥ 5 cm versus those < 5 cm were 71.8% versus 89.5% (p = 0.012). For borderline subtypes, only positive margins (p = 0.044) independently increased the risk of LR. DM developed exclusively in malignant subtypes and a prior LR event increased the risk of DM by sixfold (HR 6.2, 95% CI 1.6–16.1, p = 0.001). Conclusions: Malignant and borderline phyllodes tumors with positive margins after surgery have high LR rates. After treatment by margin-negative BCS alone, patients with large malignant phyllodes tumors ≥ 5 cm also have heightened risk of LR. Thus, such patients should be considered for additional local therapy.

UR - http://www.scopus.com/inward/record.url?scp=85047661793&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047661793&partnerID=8YFLogxK

U2 - 10.1007/s10549-018-4838-3

DO - 10.1007/s10549-018-4838-3

M3 - Article

C2 - 29808288

AN - SCOPUS:85047661793

VL - 171

SP - 335

EP - 344

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

IS - 2

ER -