Malnutrition Identified by the Nutritional Risk Index and Poor Prognosis in Advanced Epithelial Ovarian Carcinoma

Ga Won Yim, Kyung Jin Eoh, Sang Wun Kim, Eun Ji Nam, YoungTae Kim

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Ovarian cancer is a chronic disease with a risk of malnutrition. Nutritional Risk Index (NRI) has been reported as a simple and accurate tool to assess the nutritional status. We sought to explore the prevalence of malnutrition and its association with survival in ovarian cancer. A retrospective study was conducted in 213 advanced ovarian cancer patients. NRI was calculated before and at the end of treatment using patients’ body weight and serum albumin level. Overall survival (OS) and progression-free survival (PFS) were estimated by Kaplan-Meier method, and associations were assessed using a Cox proportional hazards analysis adjusted for known prognostic variables. Moderate to severely malnourished patients had lower 5-yr OS (45.3%) compared to normal to mild group (64.0%), respectively (P = 0.024). Adjusted for covariates, the relative risk of death was 5.8 times higher in moderate/severely malnourished group identified at the last course of chemotherapy (HR = 5.896, 95% CI = 2.723-12.764, P<.001). Similarly, this cohort had shorter PFS compared with normal to mild risk group (median 15 vs. 28 months, P = 0.011). Malnutrition is prevalent among ovarian cancer patients and is found to be a significant predictor for mortality.

Original languageEnglish
Pages (from-to)772-779
Number of pages8
JournalNutrition and Cancer
Volume68
Issue number5
DOIs
Publication statusPublished - 2016 Jul 3

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Nutrition Assessment
Malnutrition
Ovarian Neoplasms
Carcinoma
Disease-Free Survival
Survival
Nutritional Status
Serum Albumin
Chronic Disease
Retrospective Studies
Body Weight
Drug Therapy
Mortality

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Oncology
  • Nutrition and Dietetics
  • Cancer Research

Cite this

Yim, Ga Won ; Eoh, Kyung Jin ; Kim, Sang Wun ; Nam, Eun Ji ; Kim, YoungTae. / Malnutrition Identified by the Nutritional Risk Index and Poor Prognosis in Advanced Epithelial Ovarian Carcinoma. In: Nutrition and Cancer. 2016 ; Vol. 68, No. 5. pp. 772-779.
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Malnutrition Identified by the Nutritional Risk Index and Poor Prognosis in Advanced Epithelial Ovarian Carcinoma. / Yim, Ga Won; Eoh, Kyung Jin; Kim, Sang Wun; Nam, Eun Ji; Kim, YoungTae.

In: Nutrition and Cancer, Vol. 68, No. 5, 03.07.2016, p. 772-779.

Research output: Contribution to journalArticle

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