Mammillothalamic functional connectivity and memory function in Wernicke's encephalopathy

Eosu Kim, Jeonghun Ku, Kee Namkoong, Wonho Lee, Kang Soo Lee, Ji Yeon Park, Su Young Lee, Jae Jin Kim, Sun I. Kim, Young Chul Jung

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

There is still debate over the neural mechanisms underlying pathogenic and even recovery processes of Wernicke's encephalopathy. Therefore, we attempted to validate the usefulness of resting-state functional connectivity analysis in assessing memory function and its neural correlation with the mammillothalamic tract in patients recovering from Wernicke's encephalopathy. Seven chronic alcoholics recovering from Wernicke's encephalopathy, 14 alcoholic comparisons without Wernicke's encephalopathy, and 14 healthy comparisons underwent functional connectivity MRI scans, as well as verbal and non-verbal memory tests after at least a 1 month abstinence from alcohol. Resting-state functional connectivity strength between the anterior thalamus and the mammillary bodies was investigated by calculating temporal correlations in magnetic resonance signal levels between the two regions during a 5-min passive viewing task. The mean values of the functional connectivity strength between the left anterior thalamus and the ipsilateral mammillary body differed significantly between Wernicke's encephalopathy patients and healthy comparisons (P = 0.014). This connectivity strength in alcoholic comparisons fell between those of the former two groups, with a significant difference from that of healthy comparisons (P = 0.038). In addition, the strength of this left-sided functional connectivity significantly correlated with delayed verbal recall scores (r = 0.771, P = 0.042) and verbal recognition score (r = 0.825, P = 0.022) in patients with Wernicke's encephalopathy. Our findings indicate that memory function in patients recovering from Wernicke's encephalopathy parallels the level of the mammillothalamic functional connectivity; this supports the usefulness of resting-state functional connectivity analysis as a practical alternative to pathological examination of the mammillothalamic tract in living patients with Wernicke's encephalopathy.

Original languageEnglish
Pages (from-to)369-376
Number of pages8
JournalBrain
Volume132
Issue number2
DOIs
Publication statusPublished - 2009 Feb

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Wernicke Encephalopathy
Mammillary Bodies
Anterior Thalamic Nuclei
Magnetic Resonance Imaging
Alcohol Abstinence
Alcoholics
Magnetic Resonance Spectroscopy

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Kim, E., Ku, J., Namkoong, K., Lee, W., Lee, K. S., Park, J. Y., ... Jung, Y. C. (2009). Mammillothalamic functional connectivity and memory function in Wernicke's encephalopathy. Brain, 132(2), 369-376. https://doi.org/10.1093/brain/awn311
Kim, Eosu ; Ku, Jeonghun ; Namkoong, Kee ; Lee, Wonho ; Lee, Kang Soo ; Park, Ji Yeon ; Lee, Su Young ; Kim, Jae Jin ; Kim, Sun I. ; Jung, Young Chul. / Mammillothalamic functional connectivity and memory function in Wernicke's encephalopathy. In: Brain. 2009 ; Vol. 132, No. 2. pp. 369-376.
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Kim, E, Ku, J, Namkoong, K, Lee, W, Lee, KS, Park, JY, Lee, SY, Kim, JJ, Kim, SI & Jung, YC 2009, 'Mammillothalamic functional connectivity and memory function in Wernicke's encephalopathy', Brain, vol. 132, no. 2, pp. 369-376. https://doi.org/10.1093/brain/awn311

Mammillothalamic functional connectivity and memory function in Wernicke's encephalopathy. / Kim, Eosu; Ku, Jeonghun; Namkoong, Kee; Lee, Wonho; Lee, Kang Soo; Park, Ji Yeon; Lee, Su Young; Kim, Jae Jin; Kim, Sun I.; Jung, Young Chul.

In: Brain, Vol. 132, No. 2, 02.2009, p. 369-376.

Research output: Contribution to journalArticle

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AB - There is still debate over the neural mechanisms underlying pathogenic and even recovery processes of Wernicke's encephalopathy. Therefore, we attempted to validate the usefulness of resting-state functional connectivity analysis in assessing memory function and its neural correlation with the mammillothalamic tract in patients recovering from Wernicke's encephalopathy. Seven chronic alcoholics recovering from Wernicke's encephalopathy, 14 alcoholic comparisons without Wernicke's encephalopathy, and 14 healthy comparisons underwent functional connectivity MRI scans, as well as verbal and non-verbal memory tests after at least a 1 month abstinence from alcohol. Resting-state functional connectivity strength between the anterior thalamus and the mammillary bodies was investigated by calculating temporal correlations in magnetic resonance signal levels between the two regions during a 5-min passive viewing task. The mean values of the functional connectivity strength between the left anterior thalamus and the ipsilateral mammillary body differed significantly between Wernicke's encephalopathy patients and healthy comparisons (P = 0.014). This connectivity strength in alcoholic comparisons fell between those of the former two groups, with a significant difference from that of healthy comparisons (P = 0.038). In addition, the strength of this left-sided functional connectivity significantly correlated with delayed verbal recall scores (r = 0.771, P = 0.042) and verbal recognition score (r = 0.825, P = 0.022) in patients with Wernicke's encephalopathy. Our findings indicate that memory function in patients recovering from Wernicke's encephalopathy parallels the level of the mammillothalamic functional connectivity; this supports the usefulness of resting-state functional connectivity analysis as a practical alternative to pathological examination of the mammillothalamic tract in living patients with Wernicke's encephalopathy.

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