Manganese peroxidase-catalyzed oxidative degradation of vanillylacetone

Sangpill Hwang, Chang Ha Lee, Ik Sung Ahn, Kwangyong Park

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1 Citation (Scopus)

Abstract

When 4-(4-hydroxy-3-methoxy-phenyl)-2-butanone (vanillylacetone) was tested for manganese peroxidase (MnP)-catalyzed oxidation, it was found to be degraded with the cleavage of an aromatic ring. Among numerous products of vanillylacetone oxidation, four major ones were purified by thin-layer chromatography and identified using mass spectroscopy (MS) and nuclear magnetic resonance (NMR) analysis. Three of them maintained the aromatic ring structure and were identified as 4-[6,2′-dihydroxy-5,3′-dimethoxy-5′-(3-oxo-butyl)-biphenyl]-butan-2-one, 4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one, and 4-[6,2′-dihydroxy-5,3′-dimethoxy-5′-(3-oxo-butyl)-biphenyl]-3-buten-2-one. Even though the fourth product could not be purified to a single compound, data from infrared spectroscopy showed that it did not have a benzene ring. From MS and NMR analysis, 3-(3-oxo-butyl)-hexa-2,4-dienedioic acid-1-methyl ester was tentatively suggested as the dominant species. The reaction mechanism was suggested on the basis of the structural information of these products. To our knowledge, this paper is the first report on aromatic ring cleavage of the phenolic compound by MnP.

Original languageEnglish
Pages (from-to)572-577
Number of pages6
JournalChemosphere
Volume72
Issue number4
DOIs
Publication statusPublished - 2008 Jun

Bibliographical note

Funding Information:
This work was supported by the Korea Research Foundation Grant funded by the Korea Government (MOEHRD) (KRF-2005-042-D00070).

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

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