Mangosteen extract prevents dextran sulfate sodium-induced colitis in mice by suppressing NF-κB activation and inflammation

Hee Sung Chae, Byoung Hoon You, Jieun Song, Hyuk Wan Ko, Young Hee Choi, Young Won Chin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In this study, the anti-inflammatory effects of mangosteen extract (MGE) on dextran sulfate sodium (DSS)-induced colitis in mice and nuclear factor (NF)-κB pathway modulation were investigated. Acute colitis was induced by administering 3% DSS in drinking water for 7 days, and three groups of Institute of Cancer Research mice were treated with 30 and 120 mg/kg MGE or 5-aminosalicylic acid for 7 days; an additional two groups of mice served as healthy and disease controls. The results indicated that MGE significantly prevented weight loss, reduced disease activity index scores, and preserved colon length compared with the findings in the untreated colitis group. MGE downregulated the NF-κB pathway by inhibiting the phosphorylation of IκB and IKK in a dose-dependent manner. These findings suggest that MGE alleviates ulcerative colitis by modulating the NF-κB pathway.

Original languageEnglish
Pages (from-to)727-733
Number of pages7
JournalJournal of Medicinal Food
Volume20
Issue number8
DOIs
Publication statusPublished - 2017 Aug 1

Fingerprint

Garcinia mangostana
Dextran Sulfate
Colitis
Inflammation
Mesalamine
Ulcerative Colitis
Drinking Water
Weight Loss
Colon
Anti-Inflammatory Agents
Down-Regulation
Phosphorylation
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Chae, Hee Sung ; You, Byoung Hoon ; Song, Jieun ; Ko, Hyuk Wan ; Choi, Young Hee ; Chin, Young Won. / Mangosteen extract prevents dextran sulfate sodium-induced colitis in mice by suppressing NF-κB activation and inflammation. In: Journal of Medicinal Food. 2017 ; Vol. 20, No. 8. pp. 727-733.
@article{707347fa43f742889a9ff55e917af331,
title = "Mangosteen extract prevents dextran sulfate sodium-induced colitis in mice by suppressing NF-κB activation and inflammation",
abstract = "In this study, the anti-inflammatory effects of mangosteen extract (MGE) on dextran sulfate sodium (DSS)-induced colitis in mice and nuclear factor (NF)-κB pathway modulation were investigated. Acute colitis was induced by administering 3{\%} DSS in drinking water for 7 days, and three groups of Institute of Cancer Research mice were treated with 30 and 120 mg/kg MGE or 5-aminosalicylic acid for 7 days; an additional two groups of mice served as healthy and disease controls. The results indicated that MGE significantly prevented weight loss, reduced disease activity index scores, and preserved colon length compared with the findings in the untreated colitis group. MGE downregulated the NF-κB pathway by inhibiting the phosphorylation of IκB and IKK in a dose-dependent manner. These findings suggest that MGE alleviates ulcerative colitis by modulating the NF-κB pathway.",
author = "Chae, {Hee Sung} and You, {Byoung Hoon} and Jieun Song and Ko, {Hyuk Wan} and Choi, {Young Hee} and Chin, {Young Won}",
year = "2017",
month = "8",
day = "1",
doi = "10.1089/jmf.2017.3944",
language = "English",
volume = "20",
pages = "727--733",
journal = "Journal of Medicinal Food",
issn = "1096-620X",
publisher = "Mary Ann Liebert Inc.",
number = "8",

}

Mangosteen extract prevents dextran sulfate sodium-induced colitis in mice by suppressing NF-κB activation and inflammation. / Chae, Hee Sung; You, Byoung Hoon; Song, Jieun; Ko, Hyuk Wan; Choi, Young Hee; Chin, Young Won.

In: Journal of Medicinal Food, Vol. 20, No. 8, 01.08.2017, p. 727-733.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Mangosteen extract prevents dextran sulfate sodium-induced colitis in mice by suppressing NF-κB activation and inflammation

AU - Chae, Hee Sung

AU - You, Byoung Hoon

AU - Song, Jieun

AU - Ko, Hyuk Wan

AU - Choi, Young Hee

AU - Chin, Young Won

PY - 2017/8/1

Y1 - 2017/8/1

N2 - In this study, the anti-inflammatory effects of mangosteen extract (MGE) on dextran sulfate sodium (DSS)-induced colitis in mice and nuclear factor (NF)-κB pathway modulation were investigated. Acute colitis was induced by administering 3% DSS in drinking water for 7 days, and three groups of Institute of Cancer Research mice were treated with 30 and 120 mg/kg MGE or 5-aminosalicylic acid for 7 days; an additional two groups of mice served as healthy and disease controls. The results indicated that MGE significantly prevented weight loss, reduced disease activity index scores, and preserved colon length compared with the findings in the untreated colitis group. MGE downregulated the NF-κB pathway by inhibiting the phosphorylation of IκB and IKK in a dose-dependent manner. These findings suggest that MGE alleviates ulcerative colitis by modulating the NF-κB pathway.

AB - In this study, the anti-inflammatory effects of mangosteen extract (MGE) on dextran sulfate sodium (DSS)-induced colitis in mice and nuclear factor (NF)-κB pathway modulation were investigated. Acute colitis was induced by administering 3% DSS in drinking water for 7 days, and three groups of Institute of Cancer Research mice were treated with 30 and 120 mg/kg MGE or 5-aminosalicylic acid for 7 days; an additional two groups of mice served as healthy and disease controls. The results indicated that MGE significantly prevented weight loss, reduced disease activity index scores, and preserved colon length compared with the findings in the untreated colitis group. MGE downregulated the NF-κB pathway by inhibiting the phosphorylation of IκB and IKK in a dose-dependent manner. These findings suggest that MGE alleviates ulcerative colitis by modulating the NF-κB pathway.

UR - http://www.scopus.com/inward/record.url?scp=85027344147&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027344147&partnerID=8YFLogxK

U2 - 10.1089/jmf.2017.3944

DO - 10.1089/jmf.2017.3944

M3 - Article

C2 - 28654307

AN - SCOPUS:85027344147

VL - 20

SP - 727

EP - 733

JO - Journal of Medicinal Food

JF - Journal of Medicinal Food

SN - 1096-620X

IS - 8

ER -