Marginal hazards model for case-cohort studies with multiple disease outcomes

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Case-cohort study designs are widely used to reduce the cost of large cohort studies while achieving the same goals, especially when the disease rate is low. A key advantage of the case-cohort study design is its capacity to use the same subcohort for several diseases or for several subtypes of disease. In order to compare the effect of a risk factor on different types of diseases, times to different events need to be modelled simultaneously. Valid statistical methods that take the correlations among the outcomes from the same subject into account need to be developed. To this end, we consider marginal proportional hazards regression models for case-cohort studies with multiple disease outcomes. We also consider generalized case-cohort designs that do not require sampling all the cases, which is more realistic for multiple disease outcomes. We propose an estimating equation approach for parameter estimation with two different types of weights. Consistency and asymptotic normality of the proposed estimators are established. Large sample approximation works well in small samples in simulation studies. The proposed methods are applied to the Busselton Health Study.

Original languageEnglish
Pages (from-to)887-901
Number of pages15
JournalBiometrika
Volume96
Issue number4
DOIs
Publication statusPublished - 2009 Dec 1

Fingerprint

Marginal Model
Hazard Models
Cohort Study
cohort studies
Proportional Hazards Models
Hazards
Cohort Studies
Case-cohort Design
experimental design
sampling
Proportional Hazards Regression
risk factors
statistical analysis
Estimating Equation
Risk Factors
Asymptotic Normality
Small Sample
Parameter estimation
Statistical method
Parameter Estimation

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)
  • Statistics and Probability
  • Mathematics(all)
  • Applied Mathematics
  • Statistics, Probability and Uncertainty

Cite this

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Marginal hazards model for case-cohort studies with multiple disease outcomes. / Kang, Sangwook; Cai, J.

In: Biometrika, Vol. 96, No. 4, 01.12.2009, p. 887-901.

Research output: Contribution to journalArticle

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