Mitochondrial reactive oxygen species (mROS) are involved in cancer initiation and progression and function as signaling molecules in many aspects of hypoxia and growth factor-mediated signaling. Here we report that matairesinol, a natural small molecule identified from the cell-based screening of 200 natural plants, suppresses mROS generation resulting in anti-angiogenic activity. A non-toxic concentration of matairesinol inhibited the proliferation of human umbilical vein endothelial cells. The compound also suppressed . in vitro angiogenesis of tube formation and chemoinvasion, as well as . in vivo angiogenesis of the chorioallantoic membrane at non-toxic doses. Furthermore, matairesinol decreased hypoxia-inducible factor-1α in hypoxic HeLa cells. These results demonstrate that matairesinol could function as a novel angiogenesis inhibitor by suppressing mROS signaling.
|Number of pages||5|
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - 2012 Apr 27|
Bibliographical noteFunding Information:
This study was partly supported by grants from the National Research Foundation of Korea , which is funded by the Korean Government ( 2009-0092964 , 2010-0017984 , F01-2009-000-10183-0 ); the Translational Research Center for Protein Function Control ( 2009-0083522 ); the Next-Generation BioGreen 21 Program (2011-8-1178), Rural Development Administration, National R&D Program, Ministry of Health & Welfare; and the Brain Korea 21 project, Republic of Korea.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology