Matairesinol inhibits angiogenesis via suppression of mitochondrial reactive oxygen species

Boram Lee, Ki Hyun Kim, Hye Jin Jung, Ho Jeong Kwon

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Mitochondrial reactive oxygen species (mROS) are involved in cancer initiation and progression and function as signaling molecules in many aspects of hypoxia and growth factor-mediated signaling. Here we report that matairesinol, a natural small molecule identified from the cell-based screening of 200 natural plants, suppresses mROS generation resulting in anti-angiogenic activity. A non-toxic concentration of matairesinol inhibited the proliferation of human umbilical vein endothelial cells. The compound also suppressed . in vitro angiogenesis of tube formation and chemoinvasion, as well as . in vivo angiogenesis of the chorioallantoic membrane at non-toxic doses. Furthermore, matairesinol decreased hypoxia-inducible factor-1α in hypoxic HeLa cells. These results demonstrate that matairesinol could function as a novel angiogenesis inhibitor by suppressing mROS signaling.

Original languageEnglish
Pages (from-to)76-80
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume421
Issue number1
DOIs
Publication statusPublished - 2012 Apr 27

Bibliographical note

Funding Information:
This study was partly supported by grants from the National Research Foundation of Korea , which is funded by the Korean Government ( 2009-0092964 , 2010-0017984 , F01-2009-000-10183-0 ); the Translational Research Center for Protein Function Control ( 2009-0083522 ); the Next-Generation BioGreen 21 Program (2011-8-1178), Rural Development Administration, National R&D Program, Ministry of Health & Welfare; and the Brain Korea 21 project, Republic of Korea.

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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