Abstract
A dynamic single-path mathematical model was developed that is capable of analyzing detailed deposition patterns of inhaled particles in human lungs. Weibel's symmetric lung morphology was adopted as the basic lung structure, and detailed transport processes were evaluated numerically using the fully implicit procedure. Deposition efficiencies by specific mechanisms were individually examined for accuracy and new empirical formulas were incorporated whenever appropriate. Deposition in the alveolar region was divided into deposition fractions in the alveolar duct and alveoli, considering active transport processes between the two regions. The deposition fractions were obtained for each airway generation, serial lung volumetric compartments, and conventional three-compartment anatomic lung regions. In addition, the surface dose and cumulative deposition with time were analyzed. The results showed excellent agreement with available experimental data. The present model provides an improvement from the previously reported models and can be used as a tool in assessing internal dose of inhaled particles under various inhalation conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 925-939 |
| Number of pages | 15 |
| Journal | Inhalation Toxicology |
| Volume | 19 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2007 Jan |
Bibliographical note
Funding Information:Although the research described in this article has been supported by the U.S. Environmental Protection Agency, it has not been subjected to agency review and therefore does not necessarily reflect the views of the agency, and no official endorsement should be inferred. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.
All Science Journal Classification (ASJC) codes
- Toxicology
- Health, Toxicology and Mutagenesis