We provide a mathematical analysis of and a numerical framework for full-field optical coherence elastography, which has unique features including micron-scale resolution, realtime processing, and noninvasive imaging. We develop a novel algorithm for transforming volumetric optical images before and after the mechanical solicitation of a sample with subcellular resolution into quantitative shear modulus distributions. This has the potential to improve sensitivities and specificities in the biological and clinical applications of optical coherence tomography.
All Science Journal Classification (ASJC) codes
- Applied Mathematics