Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of small volatile molecules using a parylene-matrix chip

Jo Il Kim, Jong Min Park, Joo Yoon Noh, Min Jung Kang, Jae Chul Pyun

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

RATIONALE In matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS), volatile small molecules have been nearly impossible to analyze because (1) such molecules evaporate under drying and vacuum conditions and (2) the organic matrix creates matrix peaks in the low mass-to-charge (m/z) range (m/z <500). In this work, the analysis of volatile small molecules using MALDI-TOFMS was realized using (1) a parylene-matrix chip to eliminate the matrix peaks of the organic matrix and (2) graphene for the effective adsorption of the small volatile molecules. METHODS The parylene-matrix chip was produced by deposition of a partially porous parylene-N thin film on a dried organic matrix array. The sample solution of volatile small molecules was mixed with the graphene and then placed on the parylene-matrix chip for MALDI-TOFMS. Analogs of chemical agents called dimethyl methyl phosphonate (DMMP) and 2-chloroethylethylsulfide (CEES) were used as model compounds for the small volatile molecules, and the sensing parameters were estimated, such as the limit of detection (LOD) and the detection range. RESULTS MALDI-TOFMS based on the parylene-matrix chip and graphene as the adsorbent could achieve a LOD of approximately 1 ppb in the detection range of 1 ppm - 1 ppb for the highly volatile DMMP and CEES. CONCLUSIONS The parylene-matrix chip with graphene can be applied for the detection of volatile small molecule analytes in the m/z ratio range of small molecules (m/z <500) using graphene as an effective adsorbent.

Original languageEnglish
Pages (from-to)2301-2306
Number of pages6
JournalRapid Communications in Mass Spectrometry
Volume28
Issue number21
DOIs
Publication statusPublished - 2014 Nov 15

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Ionization
Mass spectrometry
Desorption
Graphite
Molecules
Lasers
Organophosphonates
Adsorbents
parylene
Drying
Vacuum
Adsorption
Thin films

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry

Cite this

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title = "Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of small volatile molecules using a parylene-matrix chip",
abstract = "RATIONALE In matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS), volatile small molecules have been nearly impossible to analyze because (1) such molecules evaporate under drying and vacuum conditions and (2) the organic matrix creates matrix peaks in the low mass-to-charge (m/z) range (m/z <500). In this work, the analysis of volatile small molecules using MALDI-TOFMS was realized using (1) a parylene-matrix chip to eliminate the matrix peaks of the organic matrix and (2) graphene for the effective adsorption of the small volatile molecules. METHODS The parylene-matrix chip was produced by deposition of a partially porous parylene-N thin film on a dried organic matrix array. The sample solution of volatile small molecules was mixed with the graphene and then placed on the parylene-matrix chip for MALDI-TOFMS. Analogs of chemical agents called dimethyl methyl phosphonate (DMMP) and 2-chloroethylethylsulfide (CEES) were used as model compounds for the small volatile molecules, and the sensing parameters were estimated, such as the limit of detection (LOD) and the detection range. RESULTS MALDI-TOFMS based on the parylene-matrix chip and graphene as the adsorbent could achieve a LOD of approximately 1 ppb in the detection range of 1 ppm - 1 ppb for the highly volatile DMMP and CEES. CONCLUSIONS The parylene-matrix chip with graphene can be applied for the detection of volatile small molecule analytes in the m/z ratio range of small molecules (m/z <500) using graphene as an effective adsorbent.",
author = "Kim, {Jo Il} and Park, {Jong Min} and Noh, {Joo Yoon} and Kang, {Min Jung} and Pyun, {Jae Chul}",
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Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of small volatile molecules using a parylene-matrix chip. / Kim, Jo Il; Park, Jong Min; Noh, Joo Yoon; Kang, Min Jung; Pyun, Jae Chul.

In: Rapid Communications in Mass Spectrometry, Vol. 28, No. 21, 15.11.2014, p. 2301-2306.

Research output: Contribution to journalArticle

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T1 - Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of small volatile molecules using a parylene-matrix chip

AU - Kim, Jo Il

AU - Park, Jong Min

AU - Noh, Joo Yoon

AU - Kang, Min Jung

AU - Pyun, Jae Chul

PY - 2014/11/15

Y1 - 2014/11/15

N2 - RATIONALE In matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS), volatile small molecules have been nearly impossible to analyze because (1) such molecules evaporate under drying and vacuum conditions and (2) the organic matrix creates matrix peaks in the low mass-to-charge (m/z) range (m/z <500). In this work, the analysis of volatile small molecules using MALDI-TOFMS was realized using (1) a parylene-matrix chip to eliminate the matrix peaks of the organic matrix and (2) graphene for the effective adsorption of the small volatile molecules. METHODS The parylene-matrix chip was produced by deposition of a partially porous parylene-N thin film on a dried organic matrix array. The sample solution of volatile small molecules was mixed with the graphene and then placed on the parylene-matrix chip for MALDI-TOFMS. Analogs of chemical agents called dimethyl methyl phosphonate (DMMP) and 2-chloroethylethylsulfide (CEES) were used as model compounds for the small volatile molecules, and the sensing parameters were estimated, such as the limit of detection (LOD) and the detection range. RESULTS MALDI-TOFMS based on the parylene-matrix chip and graphene as the adsorbent could achieve a LOD of approximately 1 ppb in the detection range of 1 ppm - 1 ppb for the highly volatile DMMP and CEES. CONCLUSIONS The parylene-matrix chip with graphene can be applied for the detection of volatile small molecule analytes in the m/z ratio range of small molecules (m/z <500) using graphene as an effective adsorbent.

AB - RATIONALE In matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS), volatile small molecules have been nearly impossible to analyze because (1) such molecules evaporate under drying and vacuum conditions and (2) the organic matrix creates matrix peaks in the low mass-to-charge (m/z) range (m/z <500). In this work, the analysis of volatile small molecules using MALDI-TOFMS was realized using (1) a parylene-matrix chip to eliminate the matrix peaks of the organic matrix and (2) graphene for the effective adsorption of the small volatile molecules. METHODS The parylene-matrix chip was produced by deposition of a partially porous parylene-N thin film on a dried organic matrix array. The sample solution of volatile small molecules was mixed with the graphene and then placed on the parylene-matrix chip for MALDI-TOFMS. Analogs of chemical agents called dimethyl methyl phosphonate (DMMP) and 2-chloroethylethylsulfide (CEES) were used as model compounds for the small volatile molecules, and the sensing parameters were estimated, such as the limit of detection (LOD) and the detection range. RESULTS MALDI-TOFMS based on the parylene-matrix chip and graphene as the adsorbent could achieve a LOD of approximately 1 ppb in the detection range of 1 ppm - 1 ppb for the highly volatile DMMP and CEES. CONCLUSIONS The parylene-matrix chip with graphene can be applied for the detection of volatile small molecule analytes in the m/z ratio range of small molecules (m/z <500) using graphene as an effective adsorbent.

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