Matrix metalloproteinase-1 inhibitory activity of kaempferia pandurata roxb

Jae Seok Shim, Eun Jung Choi, Chan Woo Lee, Han Sung Kim, Jae-Kwan Hwang

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Matrix metalloproteinase (MMP)-1 is a superfamily of zinc-dependent endopeptidases that are capable of degrading all components of the extracellular matrix. Kaempferia pandurata extract (0.01-0.5μg/mL) significantly reduced the expression of MMP-1 and induced the expression of type 1 procollagen at the protein and mRNA levels in a dose-dependent manner. Ultraviolet (UV)-induced MMP-1 initiates cleavage of fibrillar collagen. Once cleaved by MMP-1, collagen can be further degraded by elevated levels of MMP-3 and MMP-9. It was found that increased MMP-1 expression due to UV irradiation was mediated by activation of itogen-activated protein kinases such as extracellular-regulated kinase (ERK), Jun N-terminal kinase (JNK), and p38 kinase. Treatment of K. pandurata extract in the range of 0.01-0.5μg/mL inhibited the UV-induced phosphorylations of ERK, JNK, and p38, respectively. Moreover, inhibition of phosphorylated ERK, JNK, and p38 by K. pandurata extract resulted in decreased c-Fos expression and c-Jun phosphorylation induced by UV light. The results strongly suggest that K. pandurata is potentially useful for the prevention and treatment of skin aging.

Original languageEnglish
Pages (from-to)601-607
Number of pages7
JournalJournal of medicinal food
Volume12
Issue number3
DOIs
Publication statusPublished - 2009 Jun 1

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Zingiberaceae
Matrix Metalloproteinase 1
Phosphotransferases
Phosphorylation
Fibrillar Collagens
Skin Aging
Matrix Metalloproteinase 3
Endopeptidases
Matrix Metalloproteinase 9
Ultraviolet Rays
Collagen Type I
Protein Kinases
Extracellular Matrix
Zinc
Collagen
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Shim, Jae Seok ; Choi, Eun Jung ; Lee, Chan Woo ; Kim, Han Sung ; Hwang, Jae-Kwan. / Matrix metalloproteinase-1 inhibitory activity of kaempferia pandurata roxb. In: Journal of medicinal food. 2009 ; Vol. 12, No. 3. pp. 601-607.
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Matrix metalloproteinase-1 inhibitory activity of kaempferia pandurata roxb. / Shim, Jae Seok; Choi, Eun Jung; Lee, Chan Woo; Kim, Han Sung; Hwang, Jae-Kwan.

In: Journal of medicinal food, Vol. 12, No. 3, 01.06.2009, p. 601-607.

Research output: Contribution to journalArticle

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