Mean platelet volume (MPV) is associated with leukoaraiosis in the apparently healthy elderly

Seong Jin Kang, Byoung Jin Park, Jae Yong Shim, Hye Ree Lee, Ji Man Hong, Yong Jae Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Leukoaraiosis refers to diffuse white matter abnormalities on MR brain scans, which have been suggested to be associated with cerebral microangiopathy and geriatric syndromes such as cognitive impairment, depressive mood and gait disturbance. MPV is a simple indicator of platelet size and has been known to be a marker of platelet activity. MPV is now considered a link between inflammation and thrombosis in multiple cardiovascular and cerebrovascular disorders including hypertension, peripheral artery disease, and stroke. This cross-sectional study aims to evaluate the association between MPV and leukoaraiosis for 223 healthy elderly subjects (142 men, 81 women; mean age 66.0 ± 5.2 years) in a health examination program including brain magnetic resonance imaging (MRI) scans. The overall prevalence rate of leukoaraiosis was 15.3%. The mean MPV was significantly higher in the leukoaraiosis group than control group: 8.4 ± 0.8 and 8.1 ± 1.0, respectively (p= 0.036). A higher value of MPV was independently associated with an increased risk of leukoaraiosis. In the multivariate logistic analysis, the odds ratio (OR) (95% confidence interval (CI)) for leukoaraiosis was 1.61 (1.02-2.53) with 1. fL of MPV increment after adjusting for confounding variables. In conclusion, MPV was found to be independently and positively associated with leukoaraiosis. This finding indicates that MPV values may be a useful additional measure in assessing the risk of leukoaraiosis in the clinical setting.

Original languageEnglish
Pages (from-to)e118-e121
JournalArchives of Gerontology and Geriatrics
Volume54
Issue number2
DOIs
Publication statusPublished - 2012 Mar 1

Fingerprint

Leukoaraiosis
Mean Platelet Volume
brain
geriatrics
hypertension
stroke
cross-sectional study
mood
Group
confidence
logistics
Disease
examination
health
Values
Blood Platelets
Cerebral Small Vessel Diseases
Cerebrovascular Disorders
Confounding Factors (Epidemiology)
Peripheral Arterial Disease

All Science Journal Classification (ASJC) codes

  • Health(social science)
  • Ageing
  • Gerontology
  • Geriatrics and Gerontology

Cite this

Kang, Seong Jin ; Park, Byoung Jin ; Shim, Jae Yong ; Lee, Hye Ree ; Hong, Ji Man ; Lee, Yong Jae. / Mean platelet volume (MPV) is associated with leukoaraiosis in the apparently healthy elderly. In: Archives of Gerontology and Geriatrics. 2012 ; Vol. 54, No. 2. pp. e118-e121.
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abstract = "Leukoaraiosis refers to diffuse white matter abnormalities on MR brain scans, which have been suggested to be associated with cerebral microangiopathy and geriatric syndromes such as cognitive impairment, depressive mood and gait disturbance. MPV is a simple indicator of platelet size and has been known to be a marker of platelet activity. MPV is now considered a link between inflammation and thrombosis in multiple cardiovascular and cerebrovascular disorders including hypertension, peripheral artery disease, and stroke. This cross-sectional study aims to evaluate the association between MPV and leukoaraiosis for 223 healthy elderly subjects (142 men, 81 women; mean age 66.0 ± 5.2 years) in a health examination program including brain magnetic resonance imaging (MRI) scans. The overall prevalence rate of leukoaraiosis was 15.3{\%}. The mean MPV was significantly higher in the leukoaraiosis group than control group: 8.4 ± 0.8 and 8.1 ± 1.0, respectively (p= 0.036). A higher value of MPV was independently associated with an increased risk of leukoaraiosis. In the multivariate logistic analysis, the odds ratio (OR) (95{\%} confidence interval (CI)) for leukoaraiosis was 1.61 (1.02-2.53) with 1. fL of MPV increment after adjusting for confounding variables. In conclusion, MPV was found to be independently and positively associated with leukoaraiosis. This finding indicates that MPV values may be a useful additional measure in assessing the risk of leukoaraiosis in the clinical setting.",
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Mean platelet volume (MPV) is associated with leukoaraiosis in the apparently healthy elderly. / Kang, Seong Jin; Park, Byoung Jin; Shim, Jae Yong; Lee, Hye Ree; Hong, Ji Man; Lee, Yong Jae.

In: Archives of Gerontology and Geriatrics, Vol. 54, No. 2, 01.03.2012, p. e118-e121.

Research output: Contribution to journalArticle

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AU - Park, Byoung Jin

AU - Shim, Jae Yong

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