Measurements of chemical warfare agent degradation products using an electrophoresis microchip with contactless conductivity detector

Joseph Wang, Martin Pumera, Greg E. Collins, Ashok Mulchandani

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

This paper reports on a microfluidic device for the screening of organophosphonate nerve agent degradation products. The miniaturized system relies on an efficient chip-based separation of alkyl methylphosphonic acids (breakdown products of Sarin, Soman, and VX nerve agents) followed by their sensitive contactless conductivity detection. Experimental parameters relevant to the separation and detection processes have been optimized to yield high sensitivity (with 48-86 μg L-1 detection limits), fast response (50 s for a three alkyl methylphosphonic acid mixture), high precision (RSD = 3.8-5.0%), and good linearity (over the 0.3-100 mg L-1 range). Applicability to natural (river) water samples is demonstrated. The new microsystem offers promise for monitoring degradation products of chemical warfare agents, with advantages of speed/warning, efficiency, portability, sample size, and cost compared to conventional ion chromatography or capillary electrophoresis systems.

Original languageEnglish
Pages (from-to)6121-6125
Number of pages5
JournalAnalytical Chemistry
Volume74
Issue number23
DOIs
Publication statusPublished - 2002 Dec 1

Fingerprint

Chemical Warfare Agents
Electrophoresis
Sarin
Soman
Detectors
Ion chromatography
Degradation
Capillary electrophoresis
Organophosphonates
Microsystems
Microfluidics
Screening
Rivers
Water
Monitoring
Costs
Nerve Agents
methylphosphonic acid

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

Cite this

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Measurements of chemical warfare agent degradation products using an electrophoresis microchip with contactless conductivity detector. / Wang, Joseph; Pumera, Martin; Collins, Greg E.; Mulchandani, Ashok.

In: Analytical Chemistry, Vol. 74, No. 23, 01.12.2002, p. 6121-6125.

Research output: Contribution to journalArticle

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