Mechanical detection of liposomes using piezoresistive cantilever

Seok Jung Hyun, Hyun Seok Kim, Yong Jun Kim, Hyo Il Jung

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

This paper firstly reports the mechanical and real-time detection of liposomes using the highly sensitive microfabricated piezoresistive cantilever sensor chip and liposome-protein interaction. The cantilevers were functionalized with the chemically modified protein C2A which recognizes the phosphatidylserine (PS) exposed on the surface of liposome. The attachment of liposome induced the bending motion of the piezoresistive cantilever and consequently generated the electrical signal changes. The sensitivity of the sensor was determined from the relationship between electrical signal and the number of liposome immobilized on the cantilever surface. This result will help challenge a new detection method to monitor various micro-sized organisms such as bacteria and animal cells.

Original languageEnglish
Pages (from-to)415-419
Number of pages5
JournalSensors and Actuators, B: Chemical
Volume117
Issue number2
DOIs
Publication statusPublished - 2006 Oct 12

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All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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