Mechanical detection of liposomes using piezoresistive cantilever

Seok Jung Hyun, Hyun Seok Kim, Yong-Jun Kim, Hyo il Jung

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

This paper firstly reports the mechanical and real-time detection of liposomes using the highly sensitive microfabricated piezoresistive cantilever sensor chip and liposome-protein interaction. The cantilevers were functionalized with the chemically modified protein C2A which recognizes the phosphatidylserine (PS) exposed on the surface of liposome. The attachment of liposome induced the bending motion of the piezoresistive cantilever and consequently generated the electrical signal changes. The sensitivity of the sensor was determined from the relationship between electrical signal and the number of liposome immobilized on the cantilever surface. This result will help challenge a new detection method to monitor various micro-sized organisms such as bacteria and animal cells.

Original languageEnglish
Pages (from-to)415-419
Number of pages5
JournalSensors and Actuators, B: Chemical
Volume117
Issue number2
DOIs
Publication statusPublished - 2006 Oct 12

Fingerprint

Liposomes
proteins
sensors
organisms
bacteria
attachment
animals
chips
sensitivity
Proteins
cells
Phosphatidylserines
Sensors
interactions
Bacteria
Animals
Cells

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

Cite this

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Mechanical detection of liposomes using piezoresistive cantilever. / Hyun, Seok Jung; Kim, Hyun Seok; Kim, Yong-Jun; Jung, Hyo il.

In: Sensors and Actuators, B: Chemical, Vol. 117, No. 2, 12.10.2006, p. 415-419.

Research output: Contribution to journalArticle

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